Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"Osteocytes"”.
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The Impact of Acetylcholine Receptors on Osteocytes and Bone Mechanoadaptation
… mechanical loads is attributed to the osteocyte. Osteocytes reside embedded in the calcified bone matrix, where they function as the resident tissue mechanotransducer. Calcium (Ca2+) signaling is a key second messenger in osteocyte mechanotransduction, however the details regarding Ca2+ signaling …
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Effects of scriptaid on osteocytes skeletal homeostasis and metabolic functions
… However, the effect of energy utilization on osteocytes’ function is currently unknown. Osteocytes are terminally differentiated osteoblasts and are deeply embedded into the mineralized matrix of bone. Previous studies have shown that PTH promotes bone anabolism, in part, by stimulating …
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The role of osteocytes in disuse and microgravity-induces bone loss
… bed rest or space flight, leads to bone loss. Osteocytes, the most abundant bone cell type, are thought to be key mechanical sensors in bone, yet the molecular mechanism of this action remains poorly understood. Improved understanding of how osteocytes regulate skeletal responses to mechanical …
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The Effects of Strain and Perilacunar Environment on the Mechanotransduction of Osteocytes
Osteocytes comprise 90-95% of all bone cells and function as the mechanosensors within bone. Individual osteocytes are embedded in lacunae, intimately connected to the surrounding bone matrix, making them ideally situated to sense the strain caused by the deformation of loaded bone; however, this …
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Regulation of Breast Cancer Cells’ Bone-Metastatic Potential by Mechanically Stimulated Osteocytes
… Bone remodeling cells can be regulated by osteocytes, the major population of cells in the bone that are embedded in the bone matrix, in response to dynamic loading on the bone. Osteocytes also signal to blood vessel-lining endothelial cells that interact closely with cancer cells during …
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Estrogen Regulation of the Wnt/β-catenin Pathway in Osteocytes in Response to Mechanical Loading
… estrogen loss) in regulation of this pathway in osteocytes is not fully understood. I hypothesize that estrogen is a critical factor in the responsiveness of the osteocyte to mechanical loading via regulation of the Wnt/β-catenin pathway; and in the absence of estrogen, osteocytes will have a …
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Signaling mechanisms that suppress the anabolic response of osteoblasts and osteocytes to fluid shear stress
… mechanical stimulation of osteoblasts and osteocytes by fluid shear stress further enhanced expression of osteocalcin when Src activity was inhibited. Importantly, fluid shear stress stimulated an increase in nuclear Src activation and activity. The mechanism by which Src participates in …
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Kalirin : novel role in osteocyte function
… for the maintenance of bone mass. Although osteocytes are deeply embedded within the mineralized matrix, they are essential for the regulation of osteoblast and osteoclast functions. However, the intracellular proteins that control the morphology and function of osteocytes, and their ability …
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In Vitro Regulation of Ptgs2 and Nos3 Expression in Clonal Osteogenic Cells Following Pulsatile Fluid Flow
… the three main cell types in bone; osteoblasts, osteocytes, and osteoclasts, osteocytes are currently thought to be the mechanosensory cells in bone. The studies described here have further elucidated the mechanism of mechanotransduction in bone.|These studies were guided by two related …
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Bone Characterization of Dicer Deficient Transgenic Mice Under Dmp1 Promoter
Osteocytes are differentiated from osteoblasts and encased in mineralized bone matrix. Dentin matrix protein 1 (DMP1) is used as a marker and highly expressed in early-stage osteocytes. MicroRNA (miRNA) are small, single-stranded non-coding RNA molecules that function in RNA inactivation and …
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Application of a Novel Quasi-3D Microscopy Technique to Investigate Early Osteocyte Mechanotransduction Events
… and pathological cellular activities of osteocytes. The mechanotransduction process in osteocytes involves spatiotemporally complex changes in cytoskeletal organization, signal activation, and whole cell mechanical properties. Most in vitro biophysical techniques currently available …
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The effects of stroke on the skeleton
… the hypothesis that in stroke, the proportion of osteocytes expressing sclerostin would be inversely associated with the surface extent of bone formation. Histological analysis revealed widespread expression of sclerostin in osteocytes and their canaliculi in all subjects. However, examining …
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Mechanically driven In vivo Osteocyte Ca2+ Signaling: Aging and Pharmacologic Effects
… to bone fragility. It is widely accepted that osteocytes are the key cells responsible for orchestrating the development of the “ideal” skeleton. This ability is attributed to osteocyte’s role as the primary mechanosensing cell that is responsible for maintaining the skeleton’s integrity …
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Strain Response in Osteocyte Lacuna Due to Mechanical Loading - a Parametric Finite Element Study Using FEBio
Osteocytes are the major type of living cells in bone and are known to be responsible for the biomechanosensory functions within the bone matrix. Osteocytes are activated by mechanical forces and regulates both osteoclasts and osteoblasts for bone resorption/formation. Not all the osteocytes are …
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Computer simulation of the osteocyte and bone lining cell network and the effect of normal physiological changes in cellular functions on that network
Osteocytes play a critical role in the regulation of bone remodelling by translating strain due to mechanical loading into biochemical signals transmitted through the interconnecting lacuno-canalicular network to bone lining cells (BLCs) on the bone surface. This work aims to examine the effects of …
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SVILUPPO DI TECNICHE PER L'ISOLAMENTO, LA CARATTERIZZAZIONE E IL DIFFERENZIAMENTO DI CELLULE STAMINALI MESENCHIMALI PER UN USO IN MEDICINA RIGENERATIVA
… different cell lineages, and in particular into osteocytes and chondrocytes. The implantation of differentiated cells obtained in vitro from MSCs isolated from biopsies taken from the patient would prevent any problem of graft rejection. The hMSCs can be found in the bone marrow and the adipose …
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Mechanisms for Osteoblast and Osteocyte Initiation and Sustainment of Bone Formation in Young-Adult and Aged Mice
… begins by investigating the genes expressed by osteocytes following loading at an early mechanosensitive (4-hr) timepoint, and later at a bone-forming (day 5) timepoint. We demonstrated increases in Ngf and Wnt1 in osteocyte-enriched intracortical bone by laser capture microdissection and …
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Mechanically-Induced Osteocyte-Th17-Cell Signaling and Osteoclastogenesis
… microdamage.|2.Increased RANKL-percent positive osteocytes and intra-cortical osteoclasts.|3.Increased inflammatory cytokines (IL-2, GRO/KC, MCP1, VEGF) associated with the stimulation and chemotaxis of both T-cells and osteoclasts.|These results raised new questions about potential T-cell …
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Adipose-Derived Stromal Cells Contribute To Spinal Cord Repair But Are Not Neural-Crest Derived Stem Cells
… of both mesodermal and ectodermal origin (e.g. osteocytes, chondrocytes, cardiac myocytes, neurons, and glia) and are easily harvested and cultured in vitro. Neural crest derived tissues have the extraordinary capacity to give rise to a wide range of tissue types: neurons and glia of the …
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Testing the reliability and selectivity of different bone-cell-specific Cre- expressing mouse models for studying bone cell metabolism
… only in late stage osteoblasts and osteocytes was used. Ctsk-Cre mouse with a driven by Ctsk promoter was used so that only osteoclasts would undergo Cre-mediated recombination. E2A-Cre mouse where the Cre recombinase is driven by a global promoter E2A was also included in this study …
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