Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"Osteocyte"”.
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Kalirin : novel role in osteocyte function
… for the maintenance of bone mass. Although osteocytes are deeply embedded within the mineralized matrix, they are essential for the regulation of osteoblast and osteoclast functions. However, the intracellular proteins that control the morphology and function of osteocytes, and their ability …
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Mechanically-Induced Osteocyte-Th17-Cell Signaling and Osteoclastogenesis
… tissue and replaces it with new bone matrix.|Osteocyte apoptosis has been associated with fatigue induced microdamage, and the localization of bone resorbing osteoclasts. However, the extracellular signals involved in the initiation of targeted bone remodeling are still unknown. While …
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Osteocyte mechanotransduction: changes with age - a parametric finite element study
… osteoblasts, which lay down new bone, and (3) osteocytes, which send signals of bone remodeling. Studies have shown that in the absence of mechanical loading, osteocytes send signals of bone resorption. Understanding the microarchitecture of bone is essential to understanding the …
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Mechanically driven In vivo Osteocyte Ca2+ Signaling: Aging and Pharmacologic Effects
… to bone fragility. It is widely accepted that osteocytes are the key cells responsible for orchestrating the development of the “ideal” skeleton. This ability is attributed to osteocyte’s role as the primary mechanosensing cell that is responsible for maintaining the skeleton’s integrity …
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The effect of bone anabolic stimuli on human osteoblast to osteocyte transition.
… risk, is associated with a decrease in both osteocyte (OY) density and viability. A great deal of evidence implicates OY as central to bone physiology and pathology (1). However, human OY biology in particular is poorly characterised. We previously showed that a variety of bone-acting factors …
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The Characterization of Osteocyte Apoptosis in a Mouse Model of Orthodontic Tooth Movement
<p>Background: Osteocyte apoptosis is regularly observed in the alveolar bone during orthodontic tooth movement (OTM). In this study, we wanted to further investigate its occurrence and localization.</p> <p>Method: Sixteen 10-12 week old male CD1 mice were loaded with NiTi springs between the right …
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Osteocyte Activity and Skeletal Muscle Relative Gene Expression Profiling After Short-term Muscle Paralysis
… bone, increased vascular porosity, and decreased osteocyte lacunar density in the tibiae. The focus of this study was to explicate a potential source of these differences and determine if changes in gait, muscle gene expression, and markers of osteocyte activity could be detected as early as one …
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Application of a Novel Quasi-3D Microscopy Technique to Investigate Early Osteocyte Mechanotransduction Events
… the early mechanical and biochemical events in osteocyte mechanotransduction. Physical forces have been increasingly implicated in normal physiological and pathological cellular activities of osteocytes. The mechanotransduction process in osteocytes involves spatiotemporally complex changes in …
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Strain Response in Osteocyte Lacuna Due to Mechanical Loading - a Parametric Finite Element Study Using FEBio
Osteocytes are the major type of living cells in bone and are known to be responsible for the biomechanosensory functions within the bone matrix. Osteocytes are activated by mechanical forces and regulates both osteoclasts and osteoblasts for bone resorption/formation. Not all the osteocytes are …
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An Investigative Study Into the Relationship of Bone Morphogenetic Protein Antagonist Expression and Osteocyte Density by Region and Quadrant
… between BMP antagonist expression and osteocyte density, lacunar densities and osteocyte viability in cortical bone. Samples of unloaded tibial bone obtained from six C57Bl/6 mice were immunohistochemically stained for gremlin and noggin expression and also underwent methyl green …
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Mechanisms for Osteoblast and Osteocyte Initiation and Sustainment of Bone Formation in Young-Adult and Aged Mice
… for loading-induced bone formation, from osteocyte mechano-sensation to osteoblast-directed bone formation, are not well understood. Elucidating these mechanisms and identifying any processes that are disrupted in aged mice can aide in the development of new anabolic drugs for treating …
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Estrogen Regulation of the Wnt/β-catenin Pathway in Osteocytes in Response to Mechanical Loading
… understood, aspect of its action is on the osteocyte, the most abundant cell in bone and thought to be the primary cell involved in sensing mechanical loads. The Wnt/β-catenin pathway is activated in the osteocyte upon mechanical loading. The role of estrogen (specifically estrogen loss) in …
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Impact of Hyperglycemia on Rat Cortical Bone Microstructure and Osteoprogenitor Cell Exhaustion
… understood. Our group previously reported that osteocyte number appeared increased in the peri-implant bone of hyperglycemic rats, which might increase cellular level cortical porosity. In this context, since there are examples of increased proliferation of cells in hyperglycemia from other …
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The Impact of Acetylcholine Receptors on Osteocytes and Bone Mechanoadaptation
… adapt to mechanical loads is attributed to the osteocyte. Osteocytes reside embedded in the calcified bone matrix, where they function as the resident tissue mechanotransducer. Calcium (Ca2+) signaling is a key second messenger in osteocyte mechanotransduction, however the details regarding Ca2+ …
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Computer simulation of the osteocyte and bone lining cell network and the effect of normal physiological changes in cellular functions on that network
Osteocytes play a critical role in the regulation of bone remodelling by translating strain due to mechanical loading into biochemical signals transmitted through the interconnecting lacuno-canalicular network to bone lining cells (BLCs) on the bone surface. This work aims to examine the effects of …
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Supporting bone regeneration: Evaluation of endocrine peptides and delivery systems for local application of lactoferrin
… (LF). Methods We developed an ex vivo osteocyte culture system, and investigated the effects of irisin and orexin on bone cells at different stages of development in vitro: on bone marrow stromal cells, osteoblasts, osteocytes, and osteoclasts. In vitro studies were conducted with three …
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Development of Precision 3D-Printed Medical Implants
… The osteogenic response of both osteoblast and osteocyte cells and the bacteria S. aureus adhesion on a newly developed titanium alloy Ti-12Nb-12Zr-12Sn alloy (Ti12), Ti-6Al-4V alloy (Ti64), and commercially pure titanium (CPT) were investigated. Materials exhibited biocompatibility and …
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The Interplay Between Bone Homeostasis, Permeability, and Fracture Toughness
… hierarchical structure and the activity of osteocytes, bone cells residing in tiny cavities within the matrix. The lacunar canalicular network surrounds these cells and forms a porous system allowing fluid to flow through interconnected spaces. This interstitial fluid movement enables …
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Exploring Microstructural Signatures of Physiological Stress through Cross-Sectional Geometry and Cortical Bone Histology
… morphotype) and ImageJ was used to automate osteocyte lacunae counts, allowing for histomorphometrics osteon morphotype and osteocyte lacunae densities to be derived. Cross-sectional properties for each individual were also collected in ImageJ. Individual medical histories were recoded using …
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