Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 39 for “"Osteoclastogenesis"”.
-
Lysosome biogenesis during osteoclastogenesis
… the observation of modifications occuring during osteoclastogenesis is a good model to observe mechanisms responsible for lysosomal enzymes traffic. Osteoclasts are bone-degrading cells. To perform this specific task they have to reorganise the sorting of their lysosomal enzymes to be able to …
-
Kinetics of notch signaling during osteoclastogenesis
… osteoclasts from bone marrow macrophages (BMMs). Osteoclastogenesis is initiated in BMMs by receptor activator of nuclear factor kappa-B ligand (RANKL) in the presence of Macrophage Colony Stimulating Factor (M-CSF). This pathway consists of four membrane bound receptors and 5 membrane bound …
-
Mechanically-Induced Osteocyte-Th17-Cell Signaling and Osteoclastogenesis
Repetitive mechanical loading can lead to microdamage in bone tissue. In order to prevent accumulation of microdamage, a repair mechanism known as targeted bone remodeling removes the damaged bone tissue and replaces it with new bone matrix.|Osteocyte apoptosis has been associated with fatigue …
-
The Role of IKKβ in Osteoclastogenesis and Inflammatory Osteolysis
… is critical for stimulation of NF-κB and osteoclastogenesis. We sought to further characterize the role of the IKK complex in osteoclastogenesis by conditionally deleting IKKβ from osteoclast precursors. Using this mouse model, we demonstrated that IKKβ is critical for differentiation of …
-
Nur77 Prevents Excessive Osteoclastogenesis by Inducing Ubiquitin Ligase Cbl-b to Mediate NFATc1 Self-Limitation
… regulatory loop to prevent excessive osteoclastogenesis. Nur77 deletion leads to low bone mass owing to augmented osteoclast differentiation and bone resorption. Mechanistically, NFATc1 induces Nur77 expression at late stage of osteoclast differentiation; in turn, Nur77 …
-
The effects of chrysin on osteoclastogenesis in RAW264.7 murine macrophages and bone metabolism in Sprague Dawley rats
… the findings suggest that chrysin inhibits osteoclastogenesis via the NFκB signalling pathway, by inhibiting the translocation from the cytoplasm to the nucleus. These findings highlight chrysin’s potential as a viable therapeutic agent in bone degenerative disorders.
-
In Vitro and In Silico Analysis of Osteoclastogenesis in Response to Inhibition of De-phosphorylation of EIF2alpha by Salubrinal and Guanabenz
… to both promote osteoblastogenesis and reduce osteoclastogenesis. This thesis focused on the role of eukaryotic translation initiation factor 2 alpha (eIF2alpha), which regulates efficiency of translational initiation. The elevation of phosphorylated eIF2alpha was reported to stimulate …
-
Role of the ARF Tumor Suppressor in Osteoclasts
… we have analyzed the role of ARF during osteoclastogenesis in vitro and found that Arf loss enhances osteoclastogenesis as demonstrated by OC number and size, protein markers of osteoclastogenesis, and increased bone resorption. Enhanced osteoclastogenesis upon Arf loss is independent of …
-
Myeloma-osteoclast interactions as a therapeutic target for multiple myeloma bone disease
… the fusion of macrophages in a process known as osteoclastogenesis. Herein, we hypothesized that multiple myeloma cells promote osteoclastogenesis through direct mechanisms by secreting RANKL, the fundamental growth factor of osteoclasts, or through the Notch signaling pathway. Additionally, we …
-
The in vitro effects of diallyl trisulfide on osteoclast formation and function in RAW 264.7 murine macrophages
… and activation in a process known as osteoclastogenesis. Diallyl trisulfide (DATS) is an organosulfur compound produced in garlic which has shown powerful anti-cancer effects in vitro including decreased expression of MAPK proteins. However, the effects of DATS on osteoclast …
-
The role of autophagy in protecting periodontium integrity, and lipopolysaccharide-induced osteoclast differentiation
… stem cells concerned in both osteogenesis and osteoclastogenesis are different, they both originate from the bone marrow, therefore the same primary human bone marrow cells containing the specific stem cell populations required for osteogenesis or osteoclastogenesis were used to establish in …
-
Role of TRAF2/6 in tumour growth and bone metastases associated with breast cancer
… role of TRAF2 and TRAF6 in breast cancer induced osteoclastogenesis and osteolysis. I observed that TRAF2, but not TRAF6, is highly expressed in a highly metastatic bone-tropic clone of the human MDA-MB-231-BT (MDA-231-BT) breast cancer cells when compared to parental MDA-MB-231 (MDA-231) cells. …
-
Characterising the role of Valosin Containing Protein (VCP) in autophagy and cell differentiation.
… of VCP in autophagy and the role of autophagy on osteoclastogenesis. I have shown that VCP co-localises with p62 and LC3 at the subcellular level in cells undergoing autophagy and that VCP co-immunoprecipitates with p62 in the autophagy-dependant manner. I have also examined the stability of VCP …
-
In vivo Genome-wide Expression Study on Human Blood B cells Suggests a Novel ESRI and MAPK3 Network for Postmenopausal Osteoporosis
… Studies showed that B cells may participate in osteoclastogenesis via expression of osteoclast-related factors, such as receptor activator of NF-kappaB ligand (RANKL), transforming growth factor beta (TGF-~), and osteoprotegerin (OPG). In addition, Bcell precursors are able to differentiate into …
-
Bone-Specific Metabolism and Mechanism of Action of Curcuminoids in Blocking Osteolysis in Breast Cancer and Other Resorptive Bone Diseases
… osteolytic lesions, nor did it inhibit osteoclastogenesis, with both TGFβ signaling and osteoclastogenesis being central to this osteolytic feed-forward loop. However, mouse bone marrow β-glucuronidase (GUSB) deconjugated curcumin-glucuronide to the active aglycone, which was maintained …
-
Roles for C-ABL and P53 in bone homeostasis and DNA damage response
… differentiation and osteoblast-dependent osteoclastogenesis, via repressing the transcription of osterix, an essential osteoblast differentiation factor. Inactivating p53 rescues osteoblast differentiation defects of mice lacking c-Abl, a p53 interacting protein. We provide evidence that …
-
Investigating the effects of CSF-1R and PI3Kdelta inhibition on a breast cancer bone metastasis model
… by tumor-derived factors that promote osteoclastogenesis and osteolysis. The PI3K pathway is activated by several of these factors, in particular CSF-1. Given the ability of PI3K signaling to promote osteoclast survival and activity in a CSF-1R dependent manner, we hypothesized that …
-
RANKL and Osteoprotegerin Levels in Response to Orthodontic Forces
… factor kappa B ligand (RANKL)—is critical for osteoclastogenesis, and osteoprotegerin (OPG) is a decoy ligand that competitively inhibits RANKL. A higher RANKL/OPG ratio is associated with areas of bone resorption, while a lower ratio occurs in areas of bone deposition and homeostasis. There …
-
Muscular Strength Training Modifies Regulation of Bone Remodeling: Inferences From Serum Biomarkers in Young Women
… Serum concentrations of OPG, a suppressor of osteoclastogenesis, increased with high-load muscular strength training that led to local increases in muscle strength and BMD. These adaptations may represent an exercise-mediated suppression of osteoclast differentiation and activity. The central …
-
The Role of Rac and Filamin A in Osteoclast Function and Osteoclast Heterogeneity
… Rho GTPases to regulate osteoclast formation (osteoclastogenesis (OCG)) and function. It was observed using this technique that FLNA-knock-out (KO) osteoclasts were smaller and produced shallower Rpits compared to WT osteoclasts. Using an osteoporosis model as well as in vivo techniques …
Page 1 of 2