Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 11 of 11 for “"OspA"”.
-
Entwicklung eines Lipoprotein-Impfstoffes aus Pflanzen : Produktion des rekombinanten 'outer surface protein A' (OspA) von Borrelia burgdorferi in Tabakchloroplasten
… Untersuchungen war das bakterielle Lipoprotein OspA (outer surface protein A) aus Borrelia burgdorferi. Dieses Protein wird zur Prävention von Lyme-Borreliose eingesetzt und frühere Untersuchungen zeigten, dass OspA sowohl in B. burgdorferi als auch nach heterologer Expression in E. coli einer …
-
Regulation of outer surface lipoprotein A in the Lyme disease spirochete Borrelia burgdorferi
… essential lipoproteins, outer surface protein A (OspA) and outer surface protein C (OspC), are reciprocally regulated throughout the B. burgdorferi lifecycle. Very little is known about the regulation of OspA. These studies elucidate the regulatory mechanisms controlling the expression of OspA. …
-
DEVELOPMENT OF A VACCINE FOR LYME DISEASE USING THE NUCLEOSIDE-MODIFIED mRNA-LNP PLATFORM
… agent of Lyme disease, outer surface protein A (OspA) is the most promising candidate for vaccine development. We have designed and synthesized an OspA-encoding mRNA-LNP vaccine and compared its immunogenicity and protective efficacy to an alum-adjuvanted OspA protein subunit vaccine. OspA …
-
Transmission Competence of B. burgdorferi Infected Ixodes Ticks and Development of an OspC-Based Lyme Disease Vaccine
… in humans. A few Outer surface protein A (OspA) based compositions are currently undergoing clinical trials for human use. Outer surface protein C (OspC) is an alternative in the same line because it induces a significant antibody response and provides strain-specific protection after the …
-
Surface Localization Determinants of Borrelia burgdorferi Lipoproteins
… to specifically mutated outer surface protein A (OspA) lipopeptides could be detected by epifluorescence microscopy in both the periplasm and on the bacterial surface. These findings supported the notion that Borrelia spirochetes do not adhere to the +2/+3/+4 sorting rules established in other …
-
Perception and Planning of Connected and Automated Vehicles
… tested using the Optimal Sub-pattern Assignment (OSPA) metric and correct assignment rate of the MIO. The system has an average accuracy assigning the MIO of 98%. The rest of this work considers the coordination of multiple CAVs from a multi-agent motion planning perspective. A centralized …
-
A small RNA regulates RpoS in the Lyme disease spirochete Borrelia burgdorferi
… major outer surface proteins OspC and OspA. Temperature is one of the key environmental signals controlling RpoS, but the molecular mechanism by which the signal is transduced remains unknown. DsrABb post-transcriptionally regulates the alternative sigma factor RpoS in response to an …
-
A small RNA regulates RpoS in the Lyme disease spirochete Borrelia burgdorferi
… major outer surface proteins OspC and OspA. Temperature is one of the key environmental signals controlling RpoS, but the molecular mechanism by which the signal is transduced remains unknown. DsrABb post-transcriptionally regulates the alternative sigma factor RpoS in response to an …
-
Elektronenmikroskopische Untersuchungen an Borrelien
… immunologisch heterogenen Oberflächenproteine OspA und OspC konnte durch Immun-Gold-Markierungen mit Hilfe typspezifischer und breitreaktiver monoklonaler Antikörper nachgewiesen werden. Typspezifische und konservierte Epitope beider Proteine befinden sich auf der Oberfläche der äußeren …
-
The Lyme Disease Spirochete, <i>Borrelia burgdorferi</i>, in Tick Species Collected from Raccoons (<i>Procyon lotor</i>) and Opossums (<i>Didelphis virginiana</i>) Trapped in the Warren and Barren Counties of South Central Kentucky
… using oligonucleotide primers specific for the OspA gene.<br> A total of 976 ticks were collected. Three different species were obtained from raccoons; <i>Dermacentor variabilis, Amblyomma americanum</i>, and <i>Ixodes sp</i>. <i>Dermacentor variabilis</i> was the only tick species found on …
-
Defining the mechanisms of microbial sensing among members of the toll-like receptor 2 sub-family
… complex. Similar results were obtained using OspA, a naturally-occurring triacylated lipoprotein agonist from Borrelia burgdorferi. Activation studies reveal that either LBP or sCD14 sensitize TLR-expressing cells to nanogram levels of either Pam3CSK4 lipopeptide or OspA lipoprotein agonist. …