Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Orthotopic Xenograft Models"”.
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Targeting the Urokinase Plasminogen Activator System Combined with Chemotherapy-a Potentially Novel Therapeutic Approach for Pancreatic Cancer
… and in combination with Gemcitabine, using orthotopic xenograft models that mimic early and advanced stages of pancreatic cancer. The findings revealed that uPA inhibition with BB20-30F alone and in combination with Gemcitabine resulted in tumour growth and metastasis suppression, likely …
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Genome-wide CRISPR Screens to Uncover Novel Therapeutic Targets in Wnt-β-catenin Driven Gastrointestinal Cancers
… RNF43 mutant pancreatic cancers in vitro and in orthotopic xenograft models. We next identified the homeobox transcription factor CDX2 as a context-dependent fitness gene and Wnt-β-catenin transcriptional target in RNF43 mutant pancreatic cancer cells. CDX2 is uniquely overexpressed in Wnt-FZD5 …
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Combined Inhibition of Lysine-Specific Demethylase 1 and Kinase Signaling as a Preclinical Treatment Strategy in Glioblastoma
… scores were calculated using Bliss synergy models. Kinase signaling was analyzed via western blot analysis, and <em>in vivo</em> efficacy was evaluated in orthotopic xenograft models.</p> <p>LSD1 knockdown and seclidemstat reduced kinase signaling in the GSC lines, while catalytic LSD1 …
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The Role of Stromal-Derived Factors in Neuroblastoma Differentiation
… agents dramatically reduces tumor growth in orthotopic xenograft models of neuroblastoma, identifying a novel combination therapy that may benefit children with this disease.</p><p>In conclusion, these studies dissect the tumor microenvironment to identify an important member of the …
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The Impact of Radiation on Glioblastoma Evolution
… on glioma stem-like cell (GSC) initiated orthotopic xenografts, and by assessing radioresistance with a reirradiation protocol. To determine the impact of ITH on intrinsic radiosensitivity, we performed whole-exome sequencing (WES) of multiple tumour fragments and corresponding …