Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Orthosteric ligands"”.
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Protein-Protein Interactions with Serotonin G Protein Coupled Receptors: Novel Targets for Neurotherapeutics Drug Discovery
… inverse agonists and antagonists that target the orthosteric site. While this approach has yielded several important medications, the development of selective orthosteric ligands is challenging and has led to the loss of many promising therapeutic candidates from the drug development pipeline due …
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Characterisation of novel alpha1-adrenoceptor ligands
… studies suggested that C2 bound within the orthosteric endogenous ligand binding pocket, but that C7-C11 interacted with a second allosteric site in a bitopic manner. 4-aminoquinoline, C9, C10, and C11 increased the dissociation rate of [3H] prazosin from the α1A-AR, suggesting allosteric …
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Exploring the molecular signatures of the ligand-receptor-Gi/o protein interactions of adenosine A1 and A3 receptors
… therapeutic targets and various types of ligands have been developed for regulating their activities. hA1R has important implications in pain regulation, epilepsy, neurodegenerative diseases and the cardiorespiratory system, while hA3R is a crucial player in neuropathic pain, immune …