Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 99 for “"Orthologue"”.
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Interaction between DVAP, the orthologue of human VAPB, and Drosophila Sac1
Amyotrophic Lateral Sclerosis (ALS) is a motor neuron disease characterizeby devastating symptoms, such as muscle weakness, paralysis, and death within 5 years of disease onset. Mutations in human (VAMP)-associated protein B (hVAPB) gene cause ALS8. Interestingly, the Drosophila VAPB (DVAP) is …
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Molecular characterization of ALDRXv4, an aldose reductase orthologue isolated from xerophyta viscosa, in response to abiotic stress
Includes bibliographical references (leaves 61-70).
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Probing Orthologue and Isoform Specific Inhibition of Kinases using In Silico Strategies: Perspectives for Improved Drug Design
… atomistic level to aid in the identification of orthologue and isoform exploitability, identifying new features to be utilized for future inhibitor design. By exploring two separate kinases and kinase targeting domains, we found that orthologues and isoforms contain distinct features, likely …
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<i>Dictyostelium discoideum</i> Protein Kinase C-orthologue <i>pkcA</i> Regulates the Actin Cytoskeleton through Interaction with Phospholipase D and p21-activated Kinase
… fruiting body. pkcA, a putative Protein Kinase C-orthologue, has previously been shown to regulate development and fruiting body formation. Here we show that pkcA is involved in cell density sensing, chemotactic signaling, cell morphology, and cell-cell cohesion. Additionally, we show through …
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Sphingolipid synthases of Toxoplasma gondii and other organisms
… To investigate this pathway in the parasite an orthologue of the SM synthase from the related apicomplexan Plasmodium falciparum was identified in the genome database as being encoded by a single copy gene. Subsequently it was characterized as a functional orthologue of the yeast AUR1p (IPC …
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Structure function analysis of the deubiquitylating enzyme Fam
… its critical role in the early embryo. Fam's orthologue in fly, Fat Facets (faf) is also developmentally regulated and is required for both drosophila eye and syncytial stage development. Given the strengths of the zebrafish system as a developmental tool, the zebrafish orthologue of Fam, usp9 …
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Comparative phylogenetic exploration of the human mitochondrial proteome: Insights into disease and metabolism
… a manually curated dataset of 190,097 predicted orthologues of the 1,550 IMPI 2017 human genes across 359 species, using reciprocal best hit analysis as the basis for orthologue prediction. I used this to explore gene history and the potential for phylogenetic profiling to predict the function of …
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The role of organelle crosstalk in a Drosophila model of Parkinson’s disease
… in mammalian models. I show that the ATAD3A fly orthologue Belphegor (Bor) does not act as an inhibitor of dPerk. Furthermore, I propose that this is due to the lack of the proline-rich motif in Drosophila, otherwise present in the protein structure of its mammalian orthologue. Mutations in …
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Decoding mechanisms of brain tumour initiating cell adaption and tumour growth
… brain tumour growth. The conserved Drosophila orthologue of TRIM3 is brain tumour (brat). A single-cell transcriptome analysis carried out by the Barros laboratory identified differentially expressed genes between Drosophila brat tumour-initiating cells (TICs) versus their control immature …
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Characterisation of the eukaryotic initiation factor 2alpha kinases of Plasmodium falciparum
… that similarly, in P. falciparum the eIF2alpha orthologue is phosphorylated in response to starvation. Here we identify the P. falciparum orthologue of the translation initiation factor eIF2alpha and provide bioinformatic evidence for the presence of three eIF2alpha kinases in P. falciparum; …
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Aquaporin 3 Water Channel Protein Gene Expression in Squalis Acanthias Dogfish Shark
… immunological techniques to demonstrate that an orthologue of mammalian AQP3 is present in the epithelial cells of Squalus acanthias dogfish shark kidney, gills, rectal gland, esophagus, stomach, eye and brain. The full-length Squalus acanthias sequence has 73.8% amino acid identity to human …
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Axon guidance in the zebrafish visual system: Analysis of Esrom Mutant
… positional cloning esrom was found to be an orthologue of PAM/Hiw/RPM-1. This large multidomain protein has an E3 ligase activity. Esrom is ubiquitously expressed in the embryo. RGCs require it for proper activation of p38 signal transduction pathway in response to lysophosphatydic acid …
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Plasmodium falciparum protein kinase CK2
… of numerous signalling pathways. A putative CK2a orthologue and two predicted CK2b subunits were identified in the P. falciparum genome (Ward et al., 2004, Anamika et al., 2005). Here we present the biochemical characterisation of the PfCK2a orthologue and both PfCK2b orthologues, and demonstrate …
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Improved In Silico Methods for Target Deconvolution in Phenotypic Screens
… the wealth of bioactivity information held for orthologue species. We therefore also focused on an in-depth analysis of orthologue bioactivity data and its relevance and applicability towards expanding compound and target bioactivity space for predictive studies. The realized protocol was …
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The Pharmacological Characterization of Hco-UNC-49, a GABA-gated Chloride Channel from the Parasitic Nematode Haemonchus contortus
… contortus GABA-gated chloride channel and is an orthologue to the UNC-49 channel from the free-living nematode Caenorhabditis elegans. Previous research by our group has shown that while the UNC-49 channels from the two nematodes share similar sequence homology they do not share identical …
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Genetic and cytological investigation of Nucleostemin-1 in Drosophila melanogaster
… (NS1-4). Nucleostemin 1 (NS1) is the closest orthologue to human NS; it shares 33% identity and 67% similarity with human NS. We show that NS1 has intrinsic GTPase and ATPase activity, and that it is present within nucleoli of most larval and adult cells. Endogenous NS1 and lightly expressed …
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Flowering in protea : a molecular and physiological study.
… flower in response to seasonal change, an orthologue of the floral inducer FLOWERING LOCUS T (FT), ProteaFT (ProFT), was isolated from ‘Carnival’ (P. compacta x P. neriifolia) and its expression pattern followed diurnally and seasonally. Finally, the functions of paralogous genes of Protea …
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THE ROLE OF ROMA IN MOUSE MAMMARY EPITHELIAL CELLS
… important steps towards identifying the human orthologue of Roma, using several in silico approaches. In particular, online microarray databases, phylogenetics, BLAST sequence alignments of conserved domains and breast cancer signatures were analysed and cross- referenced, generating a list of …
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Are Barley Dwarfing Genes Important in Tolerance to Abiotic Stress?
… of function (LoF) mutants of the barley DELLA orthologue, Sln1, were characterised and growth and development assessed. By subjecting DELLA wild-type and mutant barley plants to abiotic stress conditions (salt stress and heat shock) it was established that the increased survival conferred by …
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SirT1 regulates bone mass in vivo through regulation of osteoblast and osteoclast differentiation
… osteoporosis. SirT1, the mammalian orthologue of yeast Sir2, has been shown to be a negative regulator of PPAR[gamma] and NF[kappa]B, two transcription factors important for the differentiation of osteoblasts and osteoclasts, respectively. Here, we show that SirT1 is an important …
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