Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Orphan Disease"”.
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Quantifying the patient population of ultra-orphan diseases: a case study in X-Linked Hypohidrotic Ectodermal Dysplasia
… the true incidence and prevalence of a disease has tremendous value for the biopharmaceutical industry, particularly for orphan diseases that affect a minority of the population (in the US, the definition of orphan disease is a disorder that must affect less than 200,000 people, or 1 in …
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The development of stapled peptides as chemical tools to investigate activin A signalling and as antibacterial agents targeting MsbA-mediated efflux
… in a wide range of cancers as well as the orphan disease fibrodysplasia ossificans progressiva. In this section, stapled peptides were rationally designed with the intention of inhibiting the PPI between mature activin A and its type I receptor, thus reducing downstream intracellular …
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Discovery of overlapping 1-closed biclusters
… from the field of genomics. We predict target disease – gene relationships which are relatively weakly linked as compared to a closed bicluster in the biomedical datasets. With the help of the synthetic dataset we also show that our algorithm is generic and can be applied to various fields …