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Showing 1 to 3 of 3 for “"Ormeloxifene"”.
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Therapeutic Effects of Ormeloxifene in Cervical Cancer Carcinogenesis
… need to develop newer treatment modalities. Ormeloxifene (ORM) is a non-hormonal, anti-estrogen, oral contraceptive for human use. Growing evidences also suggest that ormeloxifene has anti-cancerous properties in a variety of cancers. Developing nanoformulation of drugs has received much …
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REGULATION OF CANCER METASTASIS BY PROTEIN KINASE D1: A GLOBAL REGULATORY CASCADE
… For proof of concept of our hypothesis we used ormeloxifene because Bryostatin-1 has mild toxicity issue. Ormeloxifene is a novel modulator of PKD1 activity and it targets rapidly dividing cells Further, we investigated the effect of ormeloxifene on activation of PKD1 leading to inhibition of …
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Development of Novel Therapeutic Strategies for Pancreatic Cancer Treatment
… (Exo-ORM) significantly enhanced the efficacy of ormeloxifene to inhibit stroma as indicated by decreased expression of α-SMA, desmin and hyaluronic acid. Exo-ORM formulation effectively inhibit EMT/SHH signaling in PanCa cells and <em>in vivo</em> models. NAT derived exosomes will be a promising …