Global ETD Search
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Showing 1 to 2 of 2 for “"Origin Recognition Complex-Associated (ORCA)"”.
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Role of ORCA/LRWD1 in the maintenance of telomere integrity
… repair machinery. In this thesis, I describe how Origin Recognition Complex-associated (ORCA/LRWD1), regulates telomere integrity in Alternative Lengthening of Telomeres (ALT) -positive cells. In the absence of Telomere Maintenance Mechanism (TMM), the end replication problem will lead to the loss …
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Role of ORCA and ORC in chromatin organization and DNA replication
In eukaryotes, Origin recognition complex (ORC) proteins establish the pre-replicative complex (pre-RC) at the origins and this is essential for the initiation of DNA replication. In human cells, ORC is a highly dynamic complex with many separate functions attributed to sub-complexes or individual …