Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Orientia"”.
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Pulmonary vascular malfunction and inflammation during Orientia tsutsugamushi infection
… illness caused by infection with the bacterium, Orientia tsutsugamushi. Scrub typhus remains a neglected tropical disease, despite being a tremendous burden in endemic areas. Lung injury is one of the most common pathologies that arise from severe cases of scrub typhus, but the underlying …
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Role of Mincle in Immune Responses to Orientia tsutsugamushi infection
… countries. The causative agent of scrub typhus, Orientia tsutsugamushi, is an obligate intracellular bacterium transmitted via bite of the Leptotrombidium mite (chigger). O. tsutsugamushi replicates in endothelial cells and macrophages (MF) and initial symptoms of infection are nonspecific, …
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Role of Mincle in Immune Responses to Orientia tsutsugamushi infection
… countries. The causative agent of scrub typhus, Orientia tsutsugamushi, is an obligate intracellular bacterium transmitted via bite of the Leptotrombidium mite (chigger). O. tsutsugamushi replicates in endothelial cells and macrophages (MF) and initial symptoms of infection are nonspecific, …
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Dysregulated TFH cell and germinal center activation in mice with severe Orientia tsutsugamushi infection
… severely understudied tropical disease caused by Orientia tsutsugamushi. It is endemic in, but not limited to, the Asia-Pacific region, with about one million cases reported every year. Its high case fatality rates and impact during WWII and the Vietnam War justify vaccine development; however, …
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Elucidation of Mechanisms of Host Immunity against Orientia tsutsugamushi in a Newly Developed Murine Model
… obligately intracellular coccobacillus, Orientia tsutsugamushi, is a long neglected but important tropical disease. Orientia tsutsugamushi causes illness in one million people each year, with an additional 1 billion people at risk. Without appropriate diagnosis and treatment, the disease …
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Development of a Murine Model of Severe Scrub Typhus And Its Use to Elucidate the Immune Response to and The Pathology that Occurs during Orientia Tsutsugamushi Infection.
… cells by the obligately intracellular bacterium Orientia tsutsugamushi. Mechanistic studies of immunity have been performed primarily in intraperitoneally inoculated mice in which Orientia is largely confined to the peritoneal cavity rather than causing disseminated endothelial infection and …
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Investigating dynein-based transport of intracellular pathogens
… by the obligate intracellular bacterium Orientia tsutsugamushi, which exploits dynein and microtubules to reach its subcellular niche at the perinucleus. Similarly, the neurotrophic virus Herpes Simplex Virus type 1 (HSV-1) undergoes dynein-dependent movement from the axonal tip of …
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Characterising the bacterial microbiota of Phlebotomus and Glossina insects : vectors of parasitic diseases
… and included the important human pathogen Orientia, implying a potential role for P. argentipes in Orientia transmission.
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Scrub typhus: Epidemiology, Diagnosis, Treatment, Prevention and Control in the Asia-Pacific Area and Worldwide
… treatment. The antigenic heterogeneity of Orientia tsutsugamushi results in reinfection with scrub typhus. As a neglected disease, there is still a large gap in our knowledge of the disease, as evidenced by the sporadic epidemiology data and other related public health data regarding scrub …
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Establishment and Improvement of Preclinical Murine Models of Severe Scrub Typhus to Define Immune Signatures and Pathogenic Mechanisms
… in endemic countries due to infection with Orientia tsutsugamushi (Ot), a seriously understudied intracellular bacterium. Scrub typhus causes 150,000 deaths per year, with an estimated 1 million cases, and a further 1 billion people at risk. No vaccine is available for this reemerging and …
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Trobicúlidos y trombiculiasis en La Rioja
… spp., Coxiella burnetii, Bartonella spp. and Orientia tsutsugamushi in chiggers, and 4) Clinical characterization of trombiculiasis in La Rioja. Our data have shown the coincidence between the seasonality of human and canine cases of trombiculiasis and the presence of larvae over vegetation in …