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Showing 1 to 2 of 2 for “"Oriented cell division"”.
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Morphogenetic signaling in growing tissues
During the development of multicellular organisms, organs grow to well-defined shapes and sizes. The proper size and patterning of tissues are ensured by signaling molecules as e.g. morphogens. Secreted from a restricted source, morphogens spread into the adjacent target tissue where they form a …
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LOCALIZED WNT3A-SOURCES INSTRUCT MITOTIC ORIENTATION: DISSECTING THE WNT3A-TRANSDUCTION MECHANISM COUPLED WITH NUMA MACHINERY
In multicellular organisms, morphogenesis and homeostasis of epithelial tissues require oriented cell divisions, which rely on the proper positioning of the mitotic spindle. Consistently, defects in epithelial polarity and spindle orientation are often coupled with loss of tissue architecture and …