Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Organotypic Hippocampal Slice Cultures"”.
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Revealing Mechanisms of Sporadic Alzheimer’s Disease by Modelling in Organotypic Hippocampal Slice Cultures
… tau tangles. These coincide with reduced hippocampal and cortical volume, synapse loss, and signs of inflammation. Neuropathology and some known genetic and environmental risk factors help give clues as to the pathogenesis of AD, but we still lack a fundamental knowledge of how exactly …
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Characterization and development of a stroke-induced model of acquired epilepsy in organotypic hippocampal slice cultures: role of the cannabinoid CB1 receptors in modulation of neuronal excitation and inhibition
… this dissertation was initiated to develop an organotypic hippocampal slice culture model of acquired epilepsy and examine the changes in distribution and function of the endogenous CB1 receptor system. We utilized 4-aminopyridine and glutamate to induce separate excitotoxic injuries to slice …
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Modelling neuroimmune interactions using organotypic slice cultures
… (BCG) on neural tissue using the model of organotypic hippocampal slice cultures; an in vitro model that overcomes the previously mentioned obstacles. The study sought to expound on immunological and electrophysiological responses to the infection. A viable and moderate BCG infection was …
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Investigating Synapse Function In Organotypic Hippocampal Slice Culture Models of Neurodegeneration
Organotypic hippocampal slice cultures (OHSCs) are a useful in vitro model for researching synapse dysfunction; they provide easy access to the tissue for biomarker analysis, whilst retaining much of the neuronal architecture and endogenous cell types, representing a reasonable compromise between …
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Chemogenetics, Induced Neurons and Pluripotent Stem Cells: Towards Advanced Gene and Cell Therapies Targeting Epilepsy
… seizure-like events in an in vitro model of TLE, organotypic hippocampal slice cultures (OHSC), without altering intrinsic properties of the hM4Di-expressing neurons, demonstrating the therapeutic potential of this technology. In papers II and III we characterized two different cell sources with …
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The role of the type-I interferon response in the aggregation of tau protein
… cell systems and in vivo. In primary neural cultures, polyI:C, a synthetic analogue of viral nucleic acids, evoked a potent cytokine response that enhanced the seeded aggregation of tau in an IFN-I dependent manner. IFN-I induced vulnerability to seeded tau aggregation was intrinsic to …