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Showing 1 to 17 of 17 for “"Organoboron compounds"”.
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Asymmetric organic synthesis using organoboron compounds
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1988.
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Synthesis and Optical Studies of Organoboron Compounds
Four-coordinate aryl borafluorenes with boron-oxygen and boron-nitrogen dative bondswere recently found to exhibit very large fluorescence Stokes shifts. The large Stokes shifts arehypothesized to arise from cleavage of the boron-donor dative bond in the excited state, via amechanism called …
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Activation of diboron reagents: The development of mild conditions for the synthesis of unique organoboron compounds
… Frankland in the pursuit of novel organometallic compounds. For more than a century, further studies of boronic acids were sparsely published. Suzuki and Miyaura jumpstarted the field in 1979 with an innovative carbon-carbon bond forming reaction employing an organoboronic acid and a carbon halide …
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Trans Addition of B-X Reagents Across Polarized Triple Bonds and Development of Sphingosine-1-Phosphate Transport Inhibitors
Organoboron compounds are ubiquitous in organic chemistry. Fundamental transformations utilizing organoboron compounds are a necessary addition to any organic chemist's synthetic toolbox. In addition to their extensive use as synthetic intermediates, organoboron compounds are being increasingly …
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A synthesis of a homologous series of aryl mono- and diboronic acids
… concentration (3,4,5). However, most of these organoboron compounds do not produce a sufficiently high tumor-to-normal tissue boron concentration ratio for practical use in human cancer chemotherapy by the neutron capture technique.</p>The knowledge that several chemical substances are …
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Enantioselective, Lewis base-catalyzed transformations: I. Polyene sulfenocyclization (preparative and mechanistic aspects) II. Sulfenofunctionalization of alkenyl boronates enabled by 1,2-boronate migration
… alkyl or aryl group to form 1,2-difunctionalized organoboron compounds. This strategy was employed together with Lewis base-catalyzed, enantioselective sulfenyl group transfer to ultimately afford chiral, non-racemic alkylboronic esters in generally high yield, high enantioselectivity, and perfect …
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Development of Novel, Regioselective Borylation Protocols
Organoboron compounds are highly valued synthetic intermediates due to their diverse array of reactivity, which is often utilized in the synthesis of valuable organic molecules. For this reason, there is significant interest in the development of novel borylation protocols, especially those whose …
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Development of Transition Metal-Catalyzed Borylation Protocols using Symmetrical and Unsymmetrical Diboron Reagents
The versatility of organoboron compounds has been demonstrated by their use as synthetic intermediates and more recently in therapeutic applications since the FDA approval of Velcade©. As a result, transition metal-catalyzed protocols to incorporate boron reagents into unsaturated compounds have …
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The Development of New Stereoselective Transformations Using Alkenyl Boronate Complexes
… catalysis has enabled access to enantioenriched organoboron compounds. The second chapter will describe our studies on the reaction between alkenyl boronate complexes and activated nitrogen heterocycles. Isoquinolines and quinolines react with alkenyl boronates to furnish alkylated, dearomatized …
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The development and applications of unsymmetrical diboron compounds
Organoboron compounds have shown a wide variety of applications in both organic synthesis and the pharmaceutical field in the past decades. Transition metal-catalyzed boration of unsaturated compounds has been studied extensively as an efficient method to install C-B bonds. Most of the previous …
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Iridium-Catalyzed Enantioselective Allylation of Alkenyl Boronates
Organoboronic esters are highly functionalizable synthetic intermediates owing to their unique reactivity that allows for pre-complexation with organometallic reagents to form boronates, which can then engage in bimolecular reactions. Furthermore, incorporation of boronic esters into their …
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Organic Synthesis: Taming Chemistry using Enabling Technologies
… with batch processes to produce two medicinal compounds, a precursor to the sacubitril and OZ439 respectively. In the respect to the precursor to sacubritil, a flow-batch integrated synthesis is developed to provide the desired product in 54% yield over 7 steps from commercially available …
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Fused Heterocycles as Spinster Homolog 2 Inhibitors and Regio- and Stereoselective Copper-Catalyzed Borylation-Protodeboronation of 1,3-Diynes: Access to (Z)-1,3-Enynes
… the potential of Spns2 as a drug target. Organoboron compounds are useful synthetic intermediates in forming C-X, C-C, and C-H bonds. One way to synthesize these compounds is through copper catalysis. Copper is favorable to other transition metals because it is an Earth-abundant, low-cost …
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Rhodium boron nitride : a recyclable catalyst for the synthesis of a-aminophosphonates and dihydropyrimidinones
Submitted in fulfillment of the requirements for the award of the Degree of Master of Applied Science in Chemistry, Durban University of Technology, Durban, South Africa, 2016.
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Boron-Mediated Semireduction of Alkynoic Acid Derivatives
Organoboron compounds are commonly used precursors for a variety of reactions in organic synthesis as is exemplified by the Suzuki-Miyaura cross-coupling, which is ubiquitous in industry and academia. Additionally, the Chan-Evans-Lam cross-coupling, lithiation-homologation, allylboration, and many …
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Selective Borylations of Carbon-Carbon pi-Bonds
Organoboron compounds are viewed as a crucial intermediate for a wide variety of reactions. The most notorious reaction that exemplifies the capability of organoboron reagents is the Suzuki-Miyaura cross-coupling reaction, which is used to generate carbon-carbon bonds under mild conditions. Because …
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The attempted synthesis of 4,4-dimethyl-3-dimethylamino-2,6-cyclohexanedione carboxamide
… in our laboratories with the aim of preparing compounds which could be used in neutron capture therapy. The purpose of this procedure is to achieve selective irradiation of a neoplactic growth by inducing radioactivity throughout that tissue. Although the results obtained in destroying tumors …