Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Organic anion transporter"”.
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Characterization of a human renal organic anion transporter
The renal excretion of organic anions, including a variety of endogenous substances, xenobiotics and their metabolites, involves an organic anion transport system with multiple specificity. The well characterized basolateral uptake step of this process involves the organic anion transporter 1 …
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Functional characterization of the human renal organic anion transporter 3 (hOAT3) and comparison to hOAT1
Die renale Sekretion organischer Anionen ist entscheidend von der basolateralen Aufnahme in das Tubulusepithel entgegen dem elektrochemischen Gradienten abhängig. Aufgrund ihrer basolateralen Lokalisation sind vermutlich zwei Transporter an diesem Prozess beteiligt, der OAT1 und der OAT3. Während …
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Imaging Myelin Basic Protein expression in a model of remyelination by Magnetic Resonance Imaging using an Organic Anion Transporter Protein gene reporter system.
Demyelination occurs in several CNS diseases. If demyelinated axons are not remyelinated they become vulnerable to irreversible degeneration. There is, therefore, a clinical need for therapies that enhance remyelination. This can be achieved by 1) pharmacologically targeting endogenous …
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Molecular transport properties of sodium/dicarboxylate cotransporters
The Na+/dicarboxylate cotransporter (NaDC1) plays important roles in absorption of citric acid cycle intermediates from the intestinal and renal tubular lumen. NaDC1 influences the homeostasis of citrate, which may be associated with the formation of kidney stones. The studies in this dissertation …
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Novel strategies to enhance bumetanide concentrations in the brain in the treatment of neonatal seizures
… by inhibiting the sodium-potassium-chloride cotransporter NKCC1. This accelerates the excitatory to inhibitory switch in GABA neurotransmission. In vitro bidirectional permeability assays were used to determine the apparent permeability of bumetanide and the potential for bumetanide efflux by …
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Differentielle Regulation organischer Anionentransporter der Oatp-Familie bei Ethinylöstradiol-induzierter Cholestase der Ratte
… of the basolateral Natrium/bile acid cotransporter (Ntcp), whereas sodium-independent uptake is maintained despite a down-regulation of the organic anion transporter Oatp1. Thus, expression of the two other rat Oatps (Oatp2 and Oatp4) was determined in estrogen-induced cholestasis. In …
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The significance of OATP and CYP450 in statin-flavonoid interactions
… conventional cytochrome P450 3A4 (CYP3A4) and organic anion transporter polypeptide (OATP) inhibitors, diltiazem, and gemfibrozil, respectively. OATP activity was validated using a fluorescent probe known as pyranine and tested if quercetin or biochanin A would inhibit pyranine uptake, which is …
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Identification of OATP1B3 as a potential therapeutic target in Recessive Dystrophic Epidermolysis Bullosa Associated Squamous Cell Carcinoma
… keratinocytes (p = 0.035). SLCO1B3 encodes the organic anion transporter OATP1B3, which is normally exclusively expressed on the basolateral membrane of hepatocytes. qRT-PCR revealed the mRNA expression level of SLCO1B3 is reduced in RDEB SCC keratinocyte cultures when COL7A1, the causal gene …
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Cloning and characterization of organic anion systems in the adrenal cortex and their role in steroid release
… and medicine. Previous studies have suggested transporter(s) may participate in this process. In this study the characteristic features of the previously demonstrated ROAT1-like exchange transport system in bovine adrenal cells were investigated with representative substrates. Corticotrophin …