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Showing 1 to 11 of 11 for “"Organelle transport"”.
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Signals Regulating Organelle Transport in Melanophores
… regulation of motor proteins driving melanosome transport, the phosphorylation states of the motors and the levels of motors on the organelles were examined. Immunoprecipitation of myosin V showed that the motor subunit is more heavily phosphorylated in cells aggregating pigment compared to cells …
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Molecular motors and organelle transport in pigment cells
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Mechanisms and Regulation of Organelle Transport in Xenopus Melanophores
Organelle transport in eukaryotic cells is a process essential to many cellular functions. Understanding the mechanisms that drive and regulate these movements is, therefore, an important goal for cell biology. We have addressed these issues by studying pigment granule motility in Xenopus …
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Lis1 and Ndel1 Regulate Dynein-Mediated Organelle Transport In Adult Neurons
… is best known for its role in retrograde axonal transport (3), but also clearly functions with Lis1 and Ndel1 to control distinct developmental processes. If embryonic defects are solely responsible for the symptoms associated with neurological disorders such as lissencephaly then post-partum …
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Regulation of Organelle Transport by Myosin v in the Cell Cycle
Eukaryotic cells utilize motor proteins to transport cargo to their correct intracellular destinations and compartmentalize the cytoplasm. While the list of motor proteins and their cargo continues to expand, little is known about the regulation of motor-cargo association. Xenopus laevis …
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Regulation of Bidirectional Microtubule-Dependent Organelle Transport in Xenopus Laevis Melanophores
The regulated transport of cellular components is of paramount importance to a number of processes in the eukaryotic cell including mitosis, protein sorting, and axis-determination. Therefore, understanding the regulatory mechanisms that govern this transport can provide important insights into …
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Identification of binding protein with kinesin18B
… play an important role in intracellular transport of vesicles and organelles in higher eukaryotic cells. This transport depends on the activity of motor proteins that interact with microtubules. Most kinesins move cargoes outwards toward the cytoplasmic membrane. Members of the kinesin …
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Molecular, biochemical and functional analysis of kinesins in Leishmania mexicana
… microtubules in a variety of cellular processes, organelle transport and cell division. Disruption of the normal function of these proteins has been shown to lead to many pathologies, including ciliopathy, neurodegenerative diseases and cancers. The current study presents a comprehensive …
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HDAC6 activity is required for efficient polarization and intracellular transport of organelles in directionally migrating cells
… and cellular components to facilitate directed organelle and vesicle transport. This ultimately establishes a persistent leading edge and represses random migration. Given that tubulin is a known substrate of HDAC6 and since microtubules (MTs) are known to play an important role in polarization …
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Force studies of intracellular transport
… and dynein are necessary for intracellular transport and a variety of other functions in the cell. They have been well characterized in simplified, single-motor, in vitro systems, but less is known about their mechanical properties in vivo, in a more complex, multi-motor environment. In …
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Role of Microtubule Motor Proteins in Adenoviral Infections
… endosome trigger escape of the virions from the organelle through membrane disruption 5-15 min post-infection and most capsids gain access to the nucleus about 30-45 min thereafter. Interestingly, adenovirus relies on the microtubule (MT) network, MT-dependent motor proteins, and virus-stimulated …