Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 286 for “"Organelle"”.
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Metabolic Regulation at Sub-Organelle Length Scales: Inter-Organelle Contacts and Lipid Droplets
Page xii is misnumbered as page xi.
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Signals Regulating Organelle Transport in Melanophores
… of the motors and the levels of motors on the organelles were examined. Immunoprecipitation of myosin V showed that the motor subunit is more heavily phosphorylated in cells aggregating pigment compared to cells dispersing pigment. Furthermore, levels of myosin V on melanosomes are higher in …
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Organelle specific mechanisms of neuronal cell death
… to involve excitotoxic cell death. Intracellular organelles have been implicated in stress sensing and contribute to cell death signaling. Mitochondria have been closely linked to apoptotic pathways and recent research has also implicated other organelles, such as the endoplasmic reticulum (ER), …
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Structural and functional cell and organelle mimics
Contains fulltext : 143210.pdf (Publisher’s version ) (Open Access)
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Molecular motors and organelle transport in pigment cells
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Mechanisms and Regulation of Organelle Transport in Xenopus Melanophores
Organelle transport in eukaryotic cells is a process essential to many cellular functions. Understanding the mechanisms that drive and regulate these movements is, therefore, an important goal for cell biology. We have addressed these issues by studying pigment granule motility in Xenopus …
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Investigating Differentiation: A Role for Organelle Inheritance in Epidermal Growth
… findings unveil a hitherto unforeseen role for organelle inheritance in mitosis and spindle alignment, in the choice of daughter progenitors to differentiate or remain stem-like, and in maintaining proper tissue architecture.</p>
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Exploring Beta Cell NADPH production using Organelle-targeted Apollo-NADP+ Sensors
… real time. We targeted Apollo-NADP+ to various organelles to probe whether organelle compartmentalization of NADPH could create disparate impacts on beta cell metabolism. We demonstrated glucose- and glutamine-stimulated NADPH responses in the mitochondria preceded those in the cytoplasm …
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Feeding, Dark Survival, and Foreign Organelle Retention in an Antarctic Dinoflagellate
… by protists of foreign plastids and other organelles obtained from algal prey is an ecologically important example of mixotrophy and also represents a potential pathway for the symbiogenetic evolution of novel permanent plastids. A gymnodinoid dinoflagellate isolated from the Ross Sea, …
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Organelle Extravaganza: A Portable Science Suitable for High School Biology Students
One (or more) supplemental file(s) may have been submitted as part of the thesis approval but was not uploaded at the time of submission. The file is not available.
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Lis1 and Ndel1 Regulate Dynein-Mediated Organelle Transport In Adult Neurons
… by RNAi inhibits axon transport of these organelles. Transport is also perturbed in DRG neurons from adult Lis1+/- mice which contain a null mutation in a single Lis1 allele and are considered a model for human lissencephaly. Finally, I present evidence that Ndel1 phosphorylation by Cdk5 …
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Regulation of Organelle Transport by Myosin v in the Cell Cycle
… transport. The movement of pigmented organelles in these cells is controlled by three motors: two microtublule motors, cytoplasmic dynein and kinesin II, and the actin motor myosin V. Here, the cell cycle regulation of myosin V was investigated. In earlier work from our lab, myosin V …
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Regulation of Bidirectional Microtubule-Dependent Organelle Transport in Xenopus Laevis Melanophores
… melanophores, which contain pigment-filled organelles termed melanosomes that can be aggregated to the perinuclear region or dispersed throughout the cytoplasm by the motor proteins kinesin-2, cytoplasmic dynein, and myosin V. While the motor proteins responsible for melanosome transport …
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Organelle remodeling and V-ATPase dynamics in the lysosome regeneration cycle
… of the molecular biology and morphology of these organelles, revealing their diverse range of functions. The heterogeneity in lysosomal pH, catalytic activity, and localisation, within the lysosome regeneration cycle has been investigated in this work. This thesis provides evidence that during …
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Roles of Phospholipase A/Acyltransferase Enzymes in Membrane Remodelling and Organelle Degradation
… they have been implicated in processes from organelle degradation during lens differentiation to host immune responses against Toxoplasma infection. However, their lipid-modifying activities in cellular contexts are poorly understood. Here, we reveal PLAAT4 as a novel broad-spectrum …
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The role of organelle crosstalk in a Drosophila model of Parkinson’s disease
… night-time sleep. This thesis investigates inter-organelle as well as inter-organ signalling using Drosophila melanogaster as a model organism. My research shows that the ER UPR kinase dPerk is an important regulator of mitochondrial function and intestinal homeostasis, suggesting dPerk as a …
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Optimization of organelle fractionation methods for quantitative analysis of gene delivery trafficking kinetics
… through 17 demonstrating that separation of the organelles was achieved. With this higher resolution fractionation, movement through the endosomal pathway can be studied in greater detail.
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TIP47 is recruited to lipid droplets and important for the organelle biogenesis and function
… der Aufnahme radioaktiv markierter Lipide in die Organellen führt. Die Analyse der Lokalisation von markierten und teilweise verkürzten TIP47-Varianten zeigte, dass die Signale, die für eine Assoziation von TIP47 mit der Oberfläche von Lipid-Tröpfchen benötigt werden, in der N-terminalen Hälfte …
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Dissecting the Role of the Lipodystrophy Protein Seipin in the Biogenesis of the Lipid Droplet Organelle
… become recognized as unique, dynamic, regulated organelles that play an essential role in fat storage. Despite this increased interest, much remains unknown. Lipid droplets have been observed to emerge from the endoplasmic reticulum, but the available models for lipid droplet biogenesis are …
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High-throughput matrix-assisted laser desorption/ionization mass spectrometry for single-cell and single-organelle measurements
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-12-04 without embargo terms
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