Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"Organ-on-a-chip"”.
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Integrated Microfluidic Culture Media Oxygenator for Organ-on-a-Chip Applications
… mimics the in vivo physiological microenvironment. Oxygen is a key element for maintaining cell viability and function in MPS devices. Thus, this thesis presents the design, fabrication, and testing of a microfluidic oxygenator chip, or "Oxychip", for providing control of oxygen …
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Design and evaluation of an instrumented microfluidic organotypic device and sensor module for organ-on-a-chip applications
Organ and tissue-on-a-chip technologies are powerful tools for drug discovery and disease modeling, yet many of these systems rely heavily on in vitro cell culture to create reductionist models of tissues and organs. Therefore, Organ-on-chip devices recapitulate some tissue functions and are useful …
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Synergistic development of an engineered biodegradable theranostic probe and lymph node organ-on-a-chip to study nanoparticle-lymphatic interactions
The lymphatic system plays a vital role in controlling immune response. Despite this, cancer often reshapes the lymphatic microenvironment and metastasizes into lymph nodes. Theranostic (therapeutic + diagnostic) nanoparticles have been used in a variety of applications, including the detection and …
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Development and Characterisation of a Vessel-On-a-Chip Model of Inflammation and Inflammatory Haemostasis
Excessive immune cell infiltration occurs during many chronic inflammatory diseases. To develop new therapies for these diseases, models of inflammation are required that recapitulate how immune cells are recruited and interact with each other and the surrounding environment. While traditional …
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3D-PRINTED MICROFLUIDICS FOR BIOMIMICRY
… nature excels in packing materials and functions into unconstrained geometries. The complexity found in nature far exceeds our current fabrication capabilities, and mimicking all the functions of nature has remained a distant dream. This thesis presents a set of 3D printing tools, processes, …
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Cryopreservation of tissue engineered skeletal muscle
… skeletal muscle plays an important role not only in the field of regenerative medicine, but also in emerging areas such as soft robotics, organ-on-a-chip models of disease, and drug testing. However, further expansion of the applications of tissue engineered skeletal muscle models will …
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Advanced Microfluidic Platforms for Studying the Stromal Compartment of Pancreatic Cancer Tumor Microenvironments
… to the aggressive biology of the tumor microenvironment (TME). Interactions between activated pancreatic stellate cells (PSCs) and pancreatic cancer cells (PCCs) give rise to dense fibrotic masses (stroma) and the concomitant avascularity and hypoxia within the TME alters metabolic activity and …
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Effects of novel macrolide compounds on cell differentiation and barrier enhancement in colon epithelium
… rannsóknir miða að því að prófa þessi lyf á “organ-on-a-chip” frumuræktunarmódeli og meta þá sameindafræðilega ferla sem liggja á bakvið þekjustyrkjandi eiginleika þessarra lyfja.
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Smooth Flow Control for On-Chip Pneumatic Micropumps
Advancements in cellular biology, microfabrication methods, and the field of microfluidics allow biologists to closely replicate in vitro environments on organ-on-a-chip devices. In order to reproduce physiological conditions and processes as accurately as possible, it is necessary to generate the …
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Analytical and Experimental Investigation of Insect Respiratory System Inspired Microfluidics
… the ability to perform complex tasks with precision. In the past two decades microfluidic technology has been used to cool integrated circuits, for exoplanetary chemical analysis, for mimicking cellular environments, and in the design of specialized organ-on-a-chip devices. While there have been …
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Sensing in 3D Printed Neural Microphysiological Systems
The research presented in this dissertation supports the overall goal of producing sensor functionalized neural microphysiological systems to enable deeper fundamental understandings of disease pathology and to provide drug screening and discovery platforms for improved clinical translation. …
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Microfluidic platforms to evaluate the effects of drugs on fertility and proteins on cancer progression – a focus on cisplatin, alpha-smooth muscle actin, and glial cell line-derived neurotrophic factor
The introduction of in vitro systems that can mimic organ physiology and allow studying the progression of diseases such as cancer is necessary to get reliable information about cell responses and test drug efficacy and toxicity. Classical cell culture systems facilitate a wide range of clinical in …
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A Glomerular Basement Membrane-on-a-Chip Model for Investigating Charge-Selective Transport Across the Human Filtration Barrier
… that mimics the kidney’s in vivo ultrafiltration process outside the body. However, during dialysis, blood–membrane interactions activate the coagulation cascade and complement system, leading to protein adsorption on the membrane surface, impaired filtration, and adverse patient outcomes. This …
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ENGINEERING STEM CELLS AND ORGANOIDS ON A CHIP FOR THE STUDY OF HUMAN HEALTH AND DISEASE
… model systems that facilitate the exploration of the profound complexity of biological tissues is essential for enhancing our understanding of human health and disease. To this end, we present engineering approaches to create stem cell-derived three-dimensional (3D) miniature models of human …
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Unravelling Spiral Ganglion Neuron Electrophysiology: Heterogeneity, Gene Therapy, and In-Vitro Testing Models
… (CIs) have emerged as a transformative solution for individuals with severe to profound hearing loss. However, the variability in CI outcomes, especially in complex listening situations, underscores the need for further advances in CI technology. One major aspect of improved CI performance is …
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An Arduino-controlled bioreactor for stimulation and in situ pH monitoring of cell cultures with Organic Thin Film Transistors
L'abstract è presente nell'allegato / the abstract is in the attachment
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Development of novel in vitro platforms to model the lung
<p>Chronic respiratory diseases are the leading cause of death and disability. Estimates suggest a ~40% increase in population with chronic respiratory diseases and ~18% increase in respiratory diseases-related deaths between 1990 and 2017 with ~545 million affected and ~3.9 million deaths in 2017. …