Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 14 of 14 for “"Organ perfusion"”.
-
Spectroscopic Technologies and Computational Approaches for Real-Time Detection of FMN as Biomarker during Machine Perfusion
Organ transplant waiting lists are progressively lengthening worldwide due to the shortage of suitable organs, resulting in a high mortality rate among patients. The traditional preservation method is static cold storage, but in recent years a new technique has emerged: machine perfusion. This …
-
Ex vivo perfusion optimization of donor liver grafts for transplantation and cell isolation
… of suboptimal sources including damaged donor organs that are not transplantable. Many of these organs have potentially reversible pathologies however, that could be treated via ex vivo perfusion thereby increasing their cell yield. With the intent to translate organ recovery by perfusion into …
-
Monitoring of cerebral oxygenation, cerebrovascular reactivity and circulatory function in preterm infants
… pressure, with no reliable assessment of end-organ perfusion. In this thesis, measurements using near-infrared spectroscopy (NIRS) and functional echocardiography were made to assess cerebral perfusion and systemic blood flow in a cohort of preterm infants undergoing intensive care. This …
-
Phenotypic and Metabolic Profiling of Biological Samples in Near Real-Time Using Raman Spectroscopy
… capable of phenotyping cells, tissues and organs. This dissertation will show exclusively the application of the Raman spectroscopy phenotypic profiling method to; (i) microbial toxicity, (ii) ex-vivo organ perfusion, and (iii) subcellular location targeting. Real-time analytical methods …
-
Extracorporeal Circulation: Effect of Long-Term (24-Hour) Circulation on Blood Components
… and in future use of blood as a potential organ perfusion medium.
-
Hypothermic Machine Perfusion of Composite Tissues
Organ perfusion systems have successfully been applied to solid organ preservation and subsequent transplantation. However, their use in limb preservation for Vascularized Composite Tissue Allotransplantation (VCA) has yet to be thoroughly investigated. This thesis explores the potential for …
-
Optimizing interventions for the treatment of vascular flow disruptions
All tissues rely on perfusion and therefore intact blood flow. When flow is disrupted the coupled interaction between the functional and fluid domains of a tissue is impeded and viability is lost. Aortic stenosis is a paradigmatic example of vascular flow disruption. In health there is no gradient …
-
Novel Implant Designs In Magnetic Drug Targeting
… physiological complications, i.e. restenosis. Organ perfusion experiments were also carried out on swine heart tissue with stent implants in the right coronary artery. The results from this work with animal tissue under physiological conditions showed similar trends to previous theoretical …
-
Laparoskopische Lebendspender-Nephrektomie und Autotransplantation nach perivaskulär injiziertem Papaverin - Experimentelle Studie am Schwein
… is to evaluate whether renal function and blood perfusion can be enhanced by periarterial application of papaverine during laparoscopic donor nephrectomy in pigs. The study is subdivided in two parts. In part one, intraoperative urine output and creatinine-clearance are measured to investigate …
-
Zur Wirkung von Vasopressin beim unkontrollierten hämorrhagischen Schock
… volume immediately and to maintain vital organ perfusion. The results of many laboratory studies and one clinical trial question the effectiveness of this treatment recommendation and suggest that in the case of uncontrolled hemorrhage aggressive fluid resuscitation may even be harmful. …
-
Leveraging Right and Left Ventricular Coupling for Optimization of Mechanical Circulatory Support
… load and energy consumption while increasing organ perfusion in the face of disease. However, there is a potential price in that coupling evolved to optimize blood flow dynamics and the complex interplay between individual cardiovascular components and interposing organs like the lung. …
-
Developing novel prophylactic approaches against SARS-CoV-2 infection
… ACE2 in human lung, cholangiocyte and intestinal organoids and in the corresponding tissues in mice and hamsters. I also show that UDCA-mediated ACE2 downregulation reduces susceptibility to SARS-CoV- 2 infection in vitro, in vivo and in human lungs and livers perfused ex situ. I then illustrate …
-
AN EXPANSION ON DIAGNOSTIC AND PROGNOSTIC MARKERS IN DOGS WITH ACUTE AND CHRONIC HEART FAILURE
… which the heart is unable to maintain sufficient organ perfusion to meet the body’s needs. Consequent hemodynamic derangements turn into increased sympathetic nervous system activity and neurohormonal dysregulation, which progressively lead to inflammation, oxidative stress and multi-organ damage …
-
Procedural generation of vascular networks for tissue engineering
… to avoid at least one of dead zones, high perfusion pressures and non-uniform flow delivery, and manual intervention in the design is common. Attempting to copy real vasculature is also not suitable: reconstructed scan data is often noisy, incomplete and contains pathologies; further, small …