Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Organ of Corti"”.
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Measurements and models of electrically-evoked motion in the gerbil organ of Corti
… and hearing sensitivity. To date, the mechanism of cochlear amplification is not well understood and remains a matter of controversy. In order to understand the role of OHC motility in cochlear micromechanics we developed a technique to measure the mechanical responses within the organ of Corti …
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In vivo physiology of gap junctions between supporting cells in the organ of Corti
Thesis (Ph.D.)--Harvard--Massachusetts Institute of Technology Division of Health Sciences and Technology, February 1999.
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Organ of Corti, The Receptor Organ of Hearing: An Animation to Supplement the Graduate, Medical, and Health Professions Neuroscience Course
… supplemental tutorial, click on the file named "organofcorti.html"; all other supplemental files are referenced within this one.
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Auditory Evoked Response Threshold Shifts and Surface Damage to the Organ of Corti in the Chinchilla Resulting From Moderate Intensity, Long Duration Noise Exposures
… in DSpace on 2015-05-14T15:08:29Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 7709094.PDF: 10598814 bytes, checksum: afa81daf3c0ec88f72033a454262a081 (MD5) Previous issue date: 1976
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A Comparison Between Behavioral Methods and Evoked Response Audiometry in Assessing Anatomical Damage to the Organ of Corti of the Chinchilla Resulting From Intense Sound Exposures
… in DSpace on 2015-05-14T15:08:28Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 7606866.PDF: 10082211 bytes, checksum: 4564f3a2ffff49e20deaae929c70e55f (MD5) Previous issue date: 1975
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Sound-induced micromechanical motions in an isolated cochlea preparation
The mechanical processes at work within the organ of Corti can be greatly elucidated by measuring both radial motions and traveling-wave behavior of structures within this organ in response to sound stimuli. To enable such measurements, we have developed a new preparation for observing …
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Hearing loss in experimental bacterial meningitis
… guinea pigs by subarachnoid inoculation of \(1 \times 10^9\) Escherichia coli K-12 or \(3 \times 10^7\) CFU Streptococcus pneumoniae serotype 2 D39 (NCTC 7466) or PLN-A, \(\Delta\)NA1 or \(\Delta\)HY1, defined isogenic derivatives of D39 deficient in pneumolysin, neuraminidase or …
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Developmental Alterations in the Distribution of Specific Lateral Wall Proteins Modify Outer Hair Cell Mechanical Properties
… outer hair cells (OHCs) housed within the organ of Corti exhibit nonlinear, mechanical responses to auditory stimulation [1]. These electromotile responses increase hearing sensitivity 100-fold (40 dB) and are responsible for frequency selectivity in the mammalian cochlea. OHC electromotile …
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Measuring material properties of tectorial membranes from normal and genetically modified mice
With the discovery of hearing disorders caused by mutations in proteins expressed in the tectorial membrane (TM), the importance of the TM in cochlear mechanics has never been clearer. However, the exact role of the TM in cochlear mechanics remains a mystery. In this thesis, I have investigated …
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Gingko biloba extracts protect auditory hair cells from cisplatin-induced ototoxicity by inhibiting perturbation of gap junctional intercellular communication
… antioxidant and enhancer for GJIC. The purpose of this study was to examine the efficiency of EGb 761 in protecting against cisplatin-induced apoptosis and disturbance of GJIC. HEI-OC1 auditory cells were cultured and treated with cisplatin (50μM) and EGb (300μg/ml) for 24 h, and then analyzed …
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ANIMAL MODELS FOR BEHAVIORAL CHANGES OR HEARING LOSS UPON ACUTE VIRUS INFECTIONS
Sequelae are defined as a condition resultant of disease, typically a chronic complication of an acute illness. Neurological sequelae are those complications involving the brain and central nervous system and can include intellectual disability, seizures, emotional instability, vision loss, and …
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CANNABINOID RECEPTORS (CB) IN COCHLEA: CHARACTERIZATION AND OTOPROTECTIVE FUNCTIONS
Endocannabinoid (eCB) system is composed of endogenous CB ligands including anandamide (AEA) and 2-Arachidonyl glycerol (2-AG), enzymes involved in their biosynthesis and degradation such as diacylglycerol lipase-α (DAGL- α), and CB receptors. Primarily, there are three types of CB receptors - CB …
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ORAL ADMINISTRATION OF EPIGALLOCATECHIN-3-GALLATE (EGCG) IS A POTENTIAL THERAPEUTIC FOR CISPLATIN-INDUCED HEARING LOSS
… damage to outer hair cells (OHCs) in basal turn of the cochlea, to spiral ganglion neurons (SGN), stria vascularis (SV) and fibrocytes of spiral ligament (SL). At the cellular level, cisplatin produces profound increases in reactive oxygen species (ROS) that stimulate cell signaling pathways …
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Clinical and Molecular Characterization of Auditory Neuropathy
… or the auditory nerve. While the presence of non-syndromic recessive multiplex families is relatively rare, it suggests that a recessive gene accounts for a certain percentage of AN individuals. This research was undertaken to test the hypothesis that non-syndromic recessive AN (NSRAN) is …
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Adeno-Associated Mediated Transduction of Sensory Epithelia Within the Guinea Pig Cochlea
… Adeno-associated virus mediated transduction of sensory epithelia within the guinea pig cochlea Chairperson: Dr. David J. Poulsen, PhD. Hearing loss is the most common disability of the senses and affects 250 million people worldwide. This condition is often caused by the degeneration of the …
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Adeno-Associated Mediated Transduction of Sensory Epithelia Within the Guinea Pig Cochlea
… Adeno-associated virus mediated transduction of sensory epithelia within the guinea pig cochlea Chairperson: Dr. David J. Poulsen, PhD. Hearing loss is the most common disability of the senses and affects 250 million people worldwide. This condition is often caused by the degeneration of the …
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An analytic model of the Cochlea and functional interpretations
The cochlea is part of the peripheral auditory system that has unique and intriguing features - for example it acts as a wave-based frequency analyzer and amplifies traveling waves. The human cochlea is particularly interesting due to its critical role in our ability to process speech. To better …
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Effects of Developmental Exposure to Environmental Contaminants on the Auditory System
… humans are exposed, primarily via consumption of contaminated fish and seafood. Developmental exposure to these contaminants can result in a variety of neurotoxic effects, including long-term auditory deficits. We assessed auditory function in adult rats developmentally exposed to a unique PCB …
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Molecular Interactions of Basic Helix Loop Helix (bHLH) Genes in Inner Ear Development
… the hearing (cochlea) and balance (vestibular) organs, comprising the sensory hair cells and sensory neurons of the cochlear (spiral) and vestibular ganglia. In mammals, inner ear sensory cells undergo terminal mitosis during embryogenesis and do not regenerate. Therefore, during postnatal life, …