Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"Organ dysfunction"”.
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The multiple organ dysfunction syndrome in mice. Characterization and interventions at tumor necrosis factor.
Contains fulltext : 146548.pdf (Publisher’s version ) (Open Access)
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C-Reactive Protein Polymorphism and Serum Levels as an Independent Risk Factor in Sickle Cell Disease
… CRP levels as independent risk factors for end-organ dysfunction (mild vs. severe) in adults with sickle cell disease. The pathogenesis of secondary complications of sickle cell disease is complex and poorly understood. Predicting the severity of these complications could assist in therapeutic …
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The role of ischaemia-reperfusion injury and mitochondrial dysfunction in organ transplantation
… ischaemia-reperfusion injury and mitochondrial dysfunction in organ transplantation Ischaemia and subsequent reperfusion is inherent to solid organ transplantation and contributes to tissue damage, organ dysfunction, and worse recipient outcome. Demand for organs for transplantation in the UK …
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Nursing Perspectives and Opinions on Early or Delayed Sepsis Treatment: A Mixed Methods Approach
… sepsis. Sepsis can lead to life threatening organ dysfunction, severe hypotension, and death when severe sepsis or septic shock is involved. Sepsis is responsible for 50% of acute kidney injury (AKI), which is the most common form of organ dysfunction seen in critical care. Sepsis associated …
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Chemokines as therapeutic targets in systematic inflammatory response syndrome
… response syndrome may lead to multiple organ dysfunction, organ failure and eventually death. Chemokines, a large family of small chemotactic cytokines, are critical inflammatory mediators in the development of both acute pancreatitis and sepsis. The present study has shown that blockage …
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Vliv funkční elektrické stimulace na svalovou sílu kriticky nemocných
… Muscle weakness is a manifestation of multi-organ dysfunction at peripheral nerve and muscle level, and its severity is that it prolongs weaning and reduces rehabilitation options in critically ill patient. New approaches to the treatment of critically ill patient lie primarily in their early …
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Biological Clocks, Inflammation, and Multiorgan Damage In Sickle Cell Disease
… Interestingly, I observed further multiple organ dysfunction, systemic, and local tissue inflammation in SCD →<em>Per1/Per2 dKO</em> mice compared to SCD→WT mice, which demonstrates that the loss of <em>Per1/Per2</em> in SCD is detrimental and contributes to these devastating effects.</p> …
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Channel activating proteases: molecular targets for correction of sodium channel dysfunction in cystic fibrosis airways disease
… regulator (CFTR). Mutations in CFTR cause multi-organ dysfunction, including in the lungs, pancreas, gastro-intestinal system and the reproductive system. However, lung disease is the major cause of morbidity and mortality in people with CF PWCF. CF lung disease is characterised by …
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Emerging concepts in the pathophysiology of acute pancreatitis
… factors that determine severity, drive multiple organ dysfunction (MODS) and cause the high mortality. New treatment paradigms are needed, and this thesis explores three paradigms that may offer novel approaches to severity assessment and treatment. Patients with acute pancreatitis are prone to …
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Serum calcitonin gene-related peptide concentrations in the horse and their relationship to the Systemic Inflammatory response
… leading to refractory hypotension and multiple organ dysfunction. The exact incidence of sepsis (SIRS due to bacterial infection) has not been reported in the equine literature (Roy 2004). Since early recognition and treatment of sepsis are associated with improved outcome the search for markers …
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Early Outgrowth Cells As A Novel Therapy for Chronic Kidney Disease
… lead to progressive damage and subsequent organ dysfunction. Current clinical therapies, consisting of aggressive blood pressure control and blockade of the renin-angiotensin system, fail to arrest this progressive injury in a significant number of patients. Early outgrowth cells (EOCs) …
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The acute effects of propranolol on metabolic dysfunction in severely burned pediatric patients
… after injury. This surge develops metabolic dysfunction that is categorized by significantly elevated energy mobilization through increased glucose production and lipolysis. These metabolic changes contribute to the morbidity associated with delayed recovery. Hyperglycemia, increased …
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Rapid pre-symptomatic diagnosis of sepsis by vibrational spectroscopy
… to an infection that causes life-threatening organ dysfunction. Each year, over 30 million cases and 5 million deaths are estimated worldwide. Diagnosis of sepsis is based on non-specific clinical signs and time consuming positive identification of the causative pathogen(s). Rapid …
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Understanding mechanisms of, and risk factors for, lung injury in the critically ill
… injury (VILI) can be associated with multiple organ dysfunction, yet the mechanisms underpinning it are unclear. It has been proposed that injurious mechanical ventilation can drive lung and distal organ injury through a process of biotrauma, and this was the focus of my research.<br/><br/>I …
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T Helper Cell Dysfunction in ANCA Associated Vasculitis
… of small blood vessels that leads to organ dysfunction. Auto-reactive B cells produce pathogenic antibodies against the neutrophil enzymes, myeloperoxidase (MPO) and proteinase 3 (PR3). Genome-wide association studies that identified the relationship between MHC class II genes and ANCA …
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Transcriptomic predictors of outcomes in acute infection
… progress to sepsis, defined as life-threatening organ dysfunction due to a dysregulated host response to infection, lead to high patient morbidity and mortality. Conditions that mimic acute infections and sepsis also lead to delays in appropriate patient care and adverse outcomes given the low …
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Der Einfluss unterschiedlichen PEEP-Niveaus (PEEP 5 versus PEEP 10 cm H2O) bei kontrollierter Beatmung und druckunterstützter Spontanatmung auf die Zytokinliberation beim induzierten Lungenversagen
… systemic circulation and may result in multiple organ dysfunction syndromes. It is much known about the interaction of PEEP during controlled and spontaneous ventilation. How the systemic cytokinrelease depends on the PEEP Level is the subject of the present study. Acute lung injury was induced …
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Acute pancreatitis - severity classification, complications and outcome
… Deaths were to a high extent related to multiple organ dysfunction. Early recurrence after biliary acute pancreatitis was common. II) A model for early prediction of severity in acute pancreatitis with artificial neural networks was developed, identifying 6 risk factors. The ROC area for the model …
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HIV positive patients in intensive care - a retrospective chart review
… as indicated by a high APACHE ΙΙ score, multiple organ dysfunction requiring inotropic support and renal replacement.
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