Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"Orexin"”.
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The Role of Orexin in Decision Making
… on a subset of the hypothalamus: hypocretin/orexin producing neurons (HONs) for their role in driving decisions related to physical activity, feeding, and cognitive constraints on decision-making. The first part of this thesis will focus on how HONs multiplex metabolic and movement-related …
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The Role of Orexin in Modulating Locomotion
The neuropeptides, orexin A/ B, are produced in the lateral hypothalamic region of the brain and are widely released in the central nervous system including locomotor regions in the brainstem and the lumbar spinal cord. Multiple lines of evidence implicate orexin as being capable of influencing …
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Orexin Signaling and the Prevention of Diet-Induced Obesity
The hypothalamic neuropeptide orexin acutely promotes appetite, yet orexin deficiency in humans and mice is associated with obesity. Prolonged effects of orexin signaling upon energy homeostasis have not been fully characterized. In this study, I utilized both genetic and pharmacologic approaches …
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Age-Related Alterations in Orexin Modulation of Septo-Hippocampal Neurotransmission
<p>Hypothalamic orexin/hypocretin neurons project widely to telencephalic regions influential in learning and memory, such as the hippocampus and the medial septum (MS) of the basal forebrain. Within the MS, orexin innervates cholinergic and GABAergic parvalbumin (PV) containing neurons that …
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Effects of Single and Dual Orexin Receptor Antagonists on Trigeminal Nociception
… from primary nociceptors to the hypothalamus. Orexins are excitatory, hypothalamic neuropeptides implicated in pain pathways, as well as regulation of sleep and hunger. More specifically, orexins are involved in trigeminal nerve transmission of migraine pain by modulating neuronal membrane …
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Investigation of Tanycytes and Orexin Neurons in the KCNA1-Null Mouse Model of Epilepsy
… to WT controls. We focused on chemosensing Orexin neurons and the Locus Coeruleus (LC) neurons and hypothesized that the activation of orexin neurons and LC neurons increases in response to repeated HH and SRS mice have a greater activation. Immunohistochemical co-labeling of orexin – c-Fos …
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The interactive and individual effects of orexin A and neurotensin in the brain on spontaneous physical activity.
… that feature the signaling of numerous peptides. Orexin A has been shown to have effects on feeding and physical activity behaviors when administered centrally or in several brain regions. This effect is site-specific and requires the presence of orexin receptors. Our lab has studied the …
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Hypothalamic orexin neurons and tanycytes: Functional and molecular aspects in a mouse model of temporal lobe epilepsy
This dissertation does not include an abstract.
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Effects of Acute Heat and Oxidative Stress on the Hepatic Expression of Orexin and Its Related Receptors
<p>It is widely known that orexin A and B peptides as well as their receptors are expressed in the hypothalamus and distributed throughout the central nervous system, but there have been few studies regarding its presences in other parts of the body. There is now evidence that orexin (ORX) and its …
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Supporting bone regeneration: Evaluation of endocrine peptides and delivery systems for local application of lactoferrin
… evaluate the myokine irisin and the neuropeptide orexin as potential bone anabolic factors and to develop a clinically suitable drug delivery system for the optimal delivery of the bone anabolic factor lactoferrin (LF). Methods We developed an ex vivo osteocyte culture system, and investigated the …
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The Role of Lateral Hypothalamic Neuropeptides in Drug Addiction and Feeding Behavior
… found that melanin concentrating hormone (MCH), orexin A and orexin B are exclusively expressed in this brain area, opening the possibility that these LH neuropeptides could be involved in feeding behavior and drug addiction. This study shows that orexin neurons, and not the nearby LH neurons …
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Metabolic signalling and neuroendocrine stress responses in pregnancy
… (IIH) and the orexigenic peptides NPY, orexin and ghrelin was investigated with particular focus on the mechanisms involved in restraining these responses during late pregnancy. IIH increased ACTH secretion similarly in both virgin and pregnant rats. Unlike most stressors IIH did not …
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Investigating Central Chemoreception-based Biomarkers of Sudden Unexpected Death in Epilepsy (SUDEP)
… SUDEP susceptibility. We assessed the role of orexin antagonism and CIH in mitigating chemoreception dysfunction in preclinical SUDEP. Using non-invasive cardiorespiratory monitoring, we found that KO mice experienced increased apneas, intermittent bradycardia and hypoxia as they approached …
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Part 1: Isolation of Orexin Receptor Regulators via a Microarray-Based,Two-Color Cell Binding Screen. Part II: Targeted Inactivation of Proteins triggered by Visible Light.
Part I. Isolation of orexin receptor regulators via a microarray-based, two-color, cell-binding screen. We have developed a novel two-color, cell-binding peptoid microarray screening approach with which we discovered new orexin receptor ligands. We found that peptoids on microarray, which showed …
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Regulation of dorsal raphe serotonergic neurons by histamine
… control by α1-adrenoreceptors, 5-HT2 receptors, orexin receptors and histamine receptors. In vitro, patch-clamp studies were performed in order to extend the investigation of 5-HT2, orexin and histamine receptors further in the hope of understanding the cellular mechanisms responsible for their …
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MOLECULAR MECHANISMS OF APPETITE AND ENERGY BALANCE
… neurons in the DMH are glutamatergic, co-express orexin-A, and project to brain reward centers. Synaptic transmission dynamics is crucial to the maintenance of energy balance and hypothalamic centers have different susceptibilities to changes in synaptic capacity, making them potential targets to …
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Identification and characterization of conserved regulatory elements by comparative genomics
… specific manner. The regulatory region of orexin (ORX) gene did not contain CNEs but the fugu ORX regulatory region was able to direct neuron-specific expression in the hypothalamus of transgenic mice. Close inspection of sequences revealed cis-regulatory elements with sequence identities …
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A Mathematical Model of the Sleep-Wake Cycle
… special regulatory function of the neuropeptide orexin is also tested by simulation.
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