Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 57 for “"Orbitofrontal Cortex"”.
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Orbitofrontal Cortex and Social Processing in Rodent Models
… altered resting state network activity in the orbitofrontal cortex (OFC) and was associated with accumulation of neurotoxin marker, acrolein, in lateral prefrontal cortex (PFC) (including OFC), indicating OFC as a brain region of interest that may contribute to social processing. Measuring GABA …
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Representations of Relative Value Coding in the Orbitofrontal Cortex and Amygdala
… different contexts, neurons in the amygdala and orbitofrontal cortex (OFC) indeed rescale their calculation of the motivational significance of stimuli that predict rewards. We used a "contrast revaluation" task in which the reward associated with one stimulus is held constant while other rewards …
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Orbitofrontal Cortex Repetitive Transcranial Magnetic Stimulation for the Treatment of Major Depressive Disorder
… rTMS in MDD targets the dorsolateral prefrontal cortex (DLPFC) or the dorsomedial prefrontal cortex (DMPFC). However, many patients do not respond to DLPFC-rTMS or DMPFC-rTMS. Recent evidence suggests that the right lateral orbitofrontal cortex (OFC) plays a key role in ‘non-reward’ functions and …
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Competitive and Noncompetitive Credit Assignment to Reward Cues in the Lateral Orbitofrontal Cortex
… to reward cues, with a focus on the lateral orbitofrontal cortex (lOFC). The lOFC has long been implicated in signaling reward expectancies, with controversy as to whether it signals the economic value of future outcomes, their sensory features to guide behavior or both. However, whether the …
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Interactions Between Medical Prefrontal Cortex, Orbitofrontal Cortex and Motor Cortex in Value-based Decision Making
… how different sub-regions of rodent prefrontal cortex contribute to value-based decision making, by comparing neural signals related to animal’s choice, its outcome, and action value in orbitofrontal cortex (OFC) and medial prefrontal cortex (mPFC) of rats performing a dynamic two-armed bandit …
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Age- and sex-specific effects of amphetamines on cognition and serotonin in the orbitofrontal cortex
… parvalbumin-immunoreactive interneurons in the orbitofrontal cortex. These studies revealed complex interactions of age and sex on drug-induced changes and heightened drug-seeking in adult rats. Taken together and in the context of broader literature, this work supports the assertion that …
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Optimism and the brain: trait optimism mediates the protective role of orbitofrontal cortex gray matter volume against anxiety
… anxiety. At the brain level, reduced volume in orbitofrontal cortex (OFC) has been linked to increased vulnerability to anxiety, whereas intact functioning of the same region seems to promote resilience and is associated with trait optimism. However, so far it is not clear whether these two …
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Examining the role of the anterior and posterior orbitofrontal cortex in emotional regulation in the common marmoset (Callithrix jacchus)
… dysfunction and structural abnormalities of the orbitofrontal cortex have been reported in a number of affective disorders, including depression and several anxiety disorders. However, research has largely centred around reward-guided decision-making and economic choice, as opposed to how it may …
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Neurochemical and Neuroanatomical Basis Of Reversal Learning In The Rat
… learning, focusing on the lateral and medial orbitofrontal cortex, as well as regions of the medial prefrontal cortex. Local temporary inactivation of these structures via infusion of a muscimol/baclofen mixture produced dissociable effects. Inactivation of the infralimbic cortex led to a …
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Say cheese! Brain imaging of texture perception
… within the right oral somatosensory and left orbitofrontal cortex using representational similarity analysis. Multi-echo denoising successfully removed head-motion related signal changes without concurrently removing brain activity; but only if steps were taken to ensure head motion during the …
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The Dissociation of Valence and Intensity Using Alliesthesia and Thermal Stimulation
… with stimulus valence included the medial orbitofrontal cortex, subgenual anterior cingulate cortex and amygdala, whereas stimulus intensity was correlated with activity in the insula, thalamus and striatum, among others. Our results suggest segregated patterns of neural activity underlying …
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Resting-State Functional Brain Networks in Bipolar Spectrum Disorder: A Graph Theoretical Investigation
… control region (dorsolateral prefrontal cortex), but increased connectivity of a brain region involved in the detection and processing of reward (bilateral orbitofrontal cortex), among participants at high risk for BSD. Participants with BSD showed increased inter-module connectivity of …
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Neural Dysfunction during Decision-Making as a Predictor of Cocaine Relapse
… activation patterns in the precuneus, bilateral orbitofrontal cortex, left insula, right dorsolateral prefrontal cortex, paracingulate, left hippocampus, and bilateral amygdala correctly classified 71% of patients by short-term and long-term relapse. This investigation suggests that neuroimaging …
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Substrates of social functioning in individuals with VCFS
… and insula volumes and smaller prefrontal cortex (PFC), orbitofrontal cortex (OFC), dorsolateral prefrontal cortex (DLPFC), insula, superior temorpal sulcus (STS), and anterior cingulate cortex (ACC) volumes relative to controls. In addition, scores on the Child Behavior Checklist (CBCL), a …
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Morphological alterations in frontotemporal dementia:
… symptom appears related to the integrity of an orbitofrontal-temporal network, as opposed to the prevailing view of a degeneration of the orbitofrontal cortex. An important question in FTD is what constitutes the morphological link between the molecular pathologies and the characteristic …
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CHARACTERIZATION OF FRONTAL CORTICAL CIRCGRIN2B_011731 IN OPIOID-INDUCED NEUROADAPATIONS
… of circGrin2b, we show that knock-down of orbitofrontal cortex (OFC) circGrin2b significantly reduces heroin intake during self-administration, while only non-significantly reducing heroin-seeking phenotypes. This suggests that OFC circGrin2b is functionally relevant to heroin …
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The Neurobiology of Reward Processing in Adolescence
… particularly in the ventral striatum (VS) and orbitofrontal cortex. Gender differences were prominent during both phases of reward processing with boys showing significantly higher activation of a number of regions, including the VS, relative to girls. We also found that the X-linked gene MAOA …
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Dissecting emotion : towards a functional neuroimaging probe for affective disorders
… paradigms in the amygdala, ventral prefrontal cortex, and anterior cingulate cortex. We studied healthy individuals? responses to complex emotion paradigms to attempt to distinguish activity in these regions. We hypothesized that the amygdala mediates ?bottom-up? processing driven by emotional …
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Contributions of Reward Identity and Time Prediction Errors to Pavlovian Learning
… did not result in activation of neurons in the orbitofrontal cortex (OFC), basolateral amygdala (BLA), or any component of the striatum. In contrast, reward identity PEs did result in the recruitment of larger neural ensembles in a specific area of the ventral tegmental area (VTA). This effect …
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