Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Oral squamous cell carcinoma"”.
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Radioresistance in oral squamous cell carcinoma
Head and Neck Squamous Cell Carcinoma (HNSCC) is the sixth most common cancer accounting for approximately 6% of all cancers worldwide. However the distribution across the globe varies considerably. The majority of small tumours of the oral cavity and upper aerodigestive tract, in the absence of …
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Innovating surgery for oral squamous cell carcinoma with targeted fluorescent and magnetic tracers
Oral squamous cell carcinoma (OSCC) is characterised by its locally aggressive nature and its high propensity to metastasise to regional lymph nodes (LN)s. It is well-established that margin status and the presence of LN metastases are two of the most important factors affecting prognosis. While …
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PARP inhibition in combination with radiation therapy for the treatment of feline oral squamous cell carcinoma
Feline oral squamous cell carcinoma (FOSCC) is a devastating tumor frequently palliated with radiation therapy (RT). Disappointingly, RT typically exerts marginal and transient tumor regression and new strategies to enhance RT efficacy are needed. Poly (ADP-ribose) polymerase (PARP) is a key …
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Evaluation of the Accuracy of Liquid-Based Oral Brush Cytology in Screening for Oral Squamous Cell Carcinoma
Das orale Plattenepithelkarzinom ist der weltweit häufigste Tumor der Mundhöhle und des Rachens. Das Ziel dieser retrospektiven Studie war die Evaluation der Treffsicherheit der flüssigkeitsbasierten oralen Bürstenbiopsie als Screening-Methode für das orale Plattenepithelkarzinom. Bei der …
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Perineural Invasion in Oral Squamous Cell Carcinoma and Salivary Gland Malignancies: Incidence, Prognostic Impact and Molecular Insight
… incidence rates of perineural invasion (PNI) in oral squamous cell carcinoma (OSCC) and salivary gland malignancies (SGMs) worldwide. PNI exhibited by some OSCC and SGMs has been known as an independent predictor of poor prognosis and an indicator of aggressive behaviour. Furthermore, the …
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EVALUATING THE CHEMOTHERAPEUTIC EFFECTS OF SR9009 AND ESOMEPRAZOLE ON ORAL SQUAMOUS CELL CARCINOMA USING CIRCADIAN-TAILORED INNOVATIVE THERAPEUTIC APPROACHES
The vast majority (95%) of oral cancer, which has an overall 5-year survival rate of 66%, is oral squamous cell carcinoma (OSCC). New potential triggers, including circadian clock disruption that is caused by multiple lifestyle traits such as chronic gastroesophageal reflux and human papillomavirus …
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An investigation into the association between cytochrome P450 and glutathione S-transferase detoxification enzyme polymorphisms and human oral squamous cell carcinoma
Oral squamous cell carcinoma is the sixth commonest cancer in the world. Most patients who develop oral cancer are elderly males who are heavy users of tobacco and alcohol although the incidence is increasing in younger individuals and in those who neither smoke nor drink. Approximately 80% of …
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Development of Electrochemical Immunosensor for Oral Cancer: Initial Outcome
Oral Squamous Cell Carcinoma (OSCC), accounting for nearly 90% of head and neck malignancies, continues to pose a global health challenge with over 250,000 new cases annually, especially in developing nations. Its frequent progression from precancerous lesions such as oral leukoplakia (OL) …
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Exploration of Chemical and Biochemical Mechanisms of Catalysis
… a wide range of chemical processes that control cellular signaling. One such enzyme is ERK2 which plays a role in the transmission of signals by catalyzing the phosphorylation of its substrates. The signaling pathway that it is a part of is important in the control of growth, cell survival and …
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Exploration of Chemical and Biochemical Mechanisms of Catalysis
… a wide range of chemical processes that control cellular signaling. One such enzyme is ERK2 which plays a role in the transmission of signals by catalyzing the phosphorylation of its substrates. The signaling pathway that it is a part of is important in the control of growth, cell survival and …
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Development of an electronic aerosol atomisation system for generating three-dimensional (3D) cells in microencapsulations and microtissues characterisation
Cell encapsulation is a micro technology widely applied in cell and tissue engineering, tissue transplantation and regenerative medicine. Various techniques had been developed for microencapsulation of cells but these techniques presented threat to the cells due to the harsh or chemical treatment …
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The use of massively parallel sequencing to study the virome, epigenome and genome of canine and feline cancers
… papillomavirus is not a common cause of feline oral squamous cell carcinoma (FOSCC) and added to the understanding that it is not caused by any other DNA or integrated dsRNA virus. In canin DLCBL (cDLBCL) we provided more evidence that the subgroups seen in human DLBCL (hDLBCL) cannot be …
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SURGICAL TREATMENT OF ORAL LEUKOPLAKIA: A RANDOMIZED CONTROLLED CLINICAL TRIAL COMPARING SURGERY WITH WAIT AND SEE APPROACH
… proposed for the management of the most common oral potentially malignant disorders (i.e., leukoplakia and erythroleukoplakia) in order to prevent the risk of oral cancer. However, there is currently no consensus on the most effective approach for the patients affected by such lesions. Surgery …
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Defining mechanisms directing YAP/TAZ-mediated tumorigenesis
… a range of epithelial-derived cancers, including oral and breast cancers, but their downstream targets and mechanisms of action are unclear. Recent studies have suggested that the pro-tumorigenic roles for YAP/TAZ relate to their convergence with growth factor signaling pathways. Based on these …
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Targeting head and neck squamous cell carcinoma through NQO1-mediated cytotoxicity
Head and neck squamous cell carcinomas (HNSCC) are a group of anatomically diverse cancers characterized by their resistance to traditional chemotherapy and radiotherapy modalities. Given that as diagnostic and therapeutic strategies in cancer treatment have seen great improvements over the last …
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The expression and role of Migration Stimulating Factor (MSF) in oral tumours
… produced by both epithelial and stromal cells during foetal development, not expressed by the majority of their normal adult counterparts, but re-expressed during pathological processes such as cancer and wound healing. Scotland has the highest occurrence of oral cancers in the UK; the …
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HPV and p16 in head and neck cancer
… (HPV) may play a causal role in head and neck carcinoma (HNSCC). The aim of this study was to investigate the prevalence of HPV DNA in HNSCC and to determine whether any correlation exists with p16 or survival. An initial pilot study of sixty formalin-fixed HNSCC was carried out in order to …
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Τα κύτταρα Langerhans στο ακανθοκυτταρικό καρκίνωμα του στόματος: ανοσοϊστοχημική μελέτη με την S-100 πρωτεΐνη
… PRESENT STUDY AN EFFORT WAS MADE TO INVESTIGATE ORAL SQUAMUS CELL CARCINOMA FOR THE PRESENCE OF LANGERHANS CELLS (L.C) IN FORMALIN-FIXED, PARAFIN-EMBEDED MATERIAL, BY USING S-100 PROTEIN IN THE INDIRECT IMMUNOPEROXIDASE METHOD. ITWAS FOUND THAT: 1) S-100 PROTEIN IS A GOOD MARKER FOR THE …
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Development of an Injectable Ablative Therapy for Resource-Limited Settings: Applications in Tumor Ablation
… of an existing technique entailing intratumoral injection of ethanol to induce necrosis of malignant cells (termed “ethanol ablation”) utilized to reduce tumor volume with either curative or palliative intent. Modifications are based on analysis of the mechanics of the injection process and …