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Showing 1 to 10 of 10 for “"Oral solid dosage forms"”.
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Hot melt extrusion (HME) processing for the development of lipid oral solid dosage forms
… (HME) for the preparation of sustained release solid lipid matrices. The use of lipids instead of polymers is a novel approach with distinct advantageous. Sustained release solid lipid matrices of diclofenac sodium (Df-Na)/Compritol® 888 ATO (888 ATO) prepared using different approaches such as …
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Development of hot-melt extrusion as a novel technique for the formulation of oral solid dosage forms
… copolymer (Eudragit® EPO) matrix to produce solid dispersions by hot-melt extrusion processing. The obtained granules were incorporated into orally disintegrating tablets (ODTs). The tablets were developed by varying the ratio of superdisintegrants such as sodium croscarmellose and …
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Development and evaluation of oral solid dosage forms for colonic delivery of drugs for the treatment of cystinosis.
… delivery of cystamine, a cysteamine derivative. Orally-ingested cysteamine formulations, used in the treatment of cystinosis, are observed to cause gastrointestinal mucosa irritation, which leads to nausea, vomiting and ulceration in affected patients. Spheronised pellets were prepared, varying …
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Trends in Pharmaceutical Product Development 2000-2010
… of this study. The emphasis of the study was on oral solid dosage forms. A combination of qualitative and quantitative methods was employed to obtain a wide view on the subject of the study. Qualitative interviews with the Finnish regulatory authorities were used to collect background information …
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Continuous manufacture of enabling formulations for a poorly soluble compound using hot melt extrusion technology
… well-established technique in the production of oral solid dosage formulations, its operating capacity has the capability to address formulation and manufacturing issues associated with drugs which possess poor solubility, permeability and bioavailability. With traditional, batch-style …
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Nanoemulsion-Loaded Hydrogels For Advanced Pharmaceutical Formulations
… properties. Among various drug products, oral solid dosage forms are the most preferred product forms dominating the market because of their high patient compliance and wide acceptance. However, conventional oral drug formulations typically require costly multistep manufacturing, and poor …
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Effect of tablet compression on the dissolution of aspirin tablets using a novel off-center paddle impeller (opi) dissolution testing system
… carried out to determine the dissolution rate of oral solid dosage forms. Among several testing devices, the USP Dissolution Apparatus 2 is the device most commonly used. However, despite its widespread use, this apparatus has been shown to produce test failures and to be very sensitive to a …
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Exploring co-milling as a strategy to improve the dissolution of poorly water-soluble drugs
… fluids remains a critical limitation to the oral absorption of many poorly water-soluble drugs. Co-milling offers a solvent-free and industrially scalable technology to overcome dissolution rate limited absorption. However, its broader application has been constrained by the complexity of …
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Design of oral insulin tablet formulations to enable manufacture and storage under ambient conditions
The development of oral peptide therapeutics is significantly limited by poor gastrointestinal bioavailability and instability during manufacturing and storage. Insulin, a peptide prone to enzymatic degradation, aggregation, and chemical modification, serves as an exemplary model for addressing …
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Fused deposition modelling three-dimensional printing of solid dosage forms
… for the design and manufacture of complex solid dosage forms with the objective of formulating personalized medicines and on-demand manufacturing. Among commercially available models, fused deposition modelling 3D-printing (FDM-3DP) has shown the potential to fabricate objects with various …