Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 147 for “"Oral administration"”.
-
Entrapment of insulin into nanometric liposomes produced by supercritical CO2 for oral administration
O diabetes mellitus é uma desordem metabólica grave resultante das falhas da ação e/ou secreção de insulina. O tratamento mais utilizado para essa enfermidade é a administração subcutânea de insulina. Entretanto, a administração crônica dessa proteína pode causar alguns efeitos adversos, como …
-
ORAL ADMINISTRATION OF EPIGALLOCATECHIN-3-GALLATE (EGCG) IS A POTENTIAL THERAPEUTIC FOR CISPLATIN-INDUCED HEARING LOSS
… anti-inflammatory and anti-tumor properties. Oral administration of EGCG to male Wistar rats reduced cisplatin-induced hearing loss, assessed by auditory brainstem responses. These changes were associated with a reduction in cisplatin-induced loss of OHCs primarily in the basal region of the …
-
Microbes for life; investigating the effects of oral administration of Lactobacillus mucosae DPC 6426 on cardiometabolic parameters
… storage at -30°C. In Chapter 3, the efficacy of oral supplementation with Lactobacillus mucosae DPC 6426 at a minimum concentration of 109 CFU/g on reducing cholesterol levels in mildly hypercholesterolaemic (≥5mmol/L and <7.5mml/L) adults over a 12-week period was investigated. Results indicated …
-
Modification of a DNA Vaccine for Oral Administration in Fish for Aquaculture by Using Non-Microbial Nanoparticles
… protect DNA vaccines such that they could be orally administered. The main objective of the study was to determine if a DNA vaccine could be effectively compounded into an orally administrable formulation with chitosan or polylactide-co-glycolide (PLG). The immune response of hybrid striped …
-
Pharmacokinetic Evaluation of a Novel Compound, Sn79, a Putative Sigma-2 Receptor Antagonist, By Intravenous and Oral Administration in Rats
Considering the alarming rates at which substance drug abuse, especially cocaine, is increasing in today's society, there is a lot of impetus on the development of medications that can effectively help alleviate its toxicity and addiction. The affinity of cocaine to sigma receptors (sigma-1 and …
-
Evaluation of the Pharmacokinetic-Pharmacodynamic relationship, Metabolism and Plasma Protein Binding of the novel antitumor agent, 2-Methoxyestradiol (2ME2), following oral administration in patients with solid tumors.
… 2ME2 will be well tolerated in clinic when given orally and will have quantifiable effects on the ex vivo markers of angiogenesis and apoptosis; 2) 2ME2 will exhibit linear pharmacokinetics; 3) Plasma protein binding will be extensive and linear; 4) Sulfation will be the major metabolic pathway …
-
The effectiveness of prophylactic etodolac on post-endodontic pain
… of this study was to determine if prophylactic oral administration of etodolac would significantly reduce post-endodontic pain, when compared to ibuprofen and a placebo.;Thirty-six patients requiring conventional root canal therapy consented to single blind oral administration of either 400 mg …
-
Toxicology of Three Plant Neurotoxins in Drosophila Melanogaster, Gallus Gallus Domesticus, and Mus Musculus
… body tissues of house mice were examined after oral administration of a sub-lethal dose of coniine. Coniine was quickly eliminated.
-
Pharmacokinetics and pharmacodynamics of some NSAIDs in horses: A pharmacological, biochemical and forensic study
… metabolism and elimination once administered orally in known physiological doses and the metabolites produced by each drug over time. The study employed well established clinical and biochemical techniques to measure blood-borne parameters and the metabolism of each drug. The results show that …
-
The Influence of Ovarian Sex Steroids on Insulin Receptor Status in Mice
… Neither 2 weeks ovariectomy nor the 2 week oral administration of oestradiol (5 ug/kg/day) to ovariectomised mice had any significant effect on the insulin binding capacity of hepatocytes in the presence of insulin concentrations ranging from 0 to 1000 ng/ml. The insulin binding capacity of …
-
Metabolism and Handling of Folates in the Mammal Especially Man
The metabolism of oral administered folates and their handling has been studied in humans. Aseptic addition methods of microbiological assay with L.casei, S.faecalis, P.cerevisiae and bioautographic techniques were employed in investigations of serum and urine folates. Studies of normal human serum …
-
The influence of pre- and post-mortem treatments of glycogen content and tenderness of poultry muscles
… glycogen content and tenderness of broiler Pectoralis major muscles were investigated. Pre-mortem treatments of the broilers included fasting, full-feeding, subcutaneous adrenaline injection, and oral administration of ethyl alcohol. The effect of stretch-tension during rigor on muscle …
-
Studies on the Pharmacokinetics of Pinacidil in Healthy Volunteers
… pinacidil were studied following intravenous and oral administration of the drug to healthy volunteers. Additional pharmacokinetic studies included the effect of food on the absorption of pinacidil and the effects of chronic dosing with pinacidil in middle-aged, healthy volunteers. The final study …
-
The role of eicoapentaenoic acid in cancer cahexia
… pathway involving, possibly, β3-adrenoceptors. Oral administration of the n-3 polyunsaturated fatty acid (PUFA) eicosapentaenoic acid (EPA) attenuated the progression of cachexia, but not the production of LMF, in MAC16 tumour-bearing mice, and was significantly incorporated into plasma …
-
Intestinal Inflammation Model Inducing Gut Leakage by Different Methods in Broiler Chickens Using FITC-d as a Marker
… for effective alternatives are urgently needed. Oral administration of fluorescein isothiocyanate dextran (FITC-d) and its passage into blood can be used as a marker for tight junction permeability. FITC-d is a large molecule (3-5 kDa) which does not usually leak through the intact …
-
Characterisation of cysteamine prodrugs for the treatment of cystinosis and evaluation of liquid fill technology.
… cause organ damage. The treatment involves the oral administration of the aminothiol, cysteamine (Cystagon(TM)), but this has an offensive taste and smell, can cause vomiting and its metabolites are excreted from the body via breath (halitosis) and sweat, which can cause poor patient compliance. …
-
Quantitative und qualitative Analyse der Derivate der Ursodeoxycholsäure im Urin gesunder Probanden
… acid (750 mg daily) was administered orally to ten healthy human subjects over a period of ten days. 24 hour urine samples were collected the day before and on the last day of the study. The samples were extracted with Sep-Pak C18 cartridges and separated into groups of conjugates The …
Page 1 of 8