Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Optical Stimulation"”.
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Flexible fibers for optoelectronic probing of spinal cord circuits
… properties, while providing functions for optical stimulation and neural recording. In this thesis, fiber drawing techniques are applied to produce flexible and stretchable probes. The utility of the devices for recording and optical stimulation is demonstrated in the spinal cord of …
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Muscle Recruitment Mechanism under Optogenetic Neuromodulation
… overall quality of life. Functional electrical stimulation (FES) is the most commonly used technology to restore motion. Although FES is used extensively in the clinic, several drawbacks limit its application for long-term use. FES recruits larger motor units before smaller ones, causing muscles …
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Development of neural probes using thermal drawing
… combining capabilities for electrical recording, optical stimulation, and drug delivery. A technique was developed to combine functionalities of these devices into a single probe to study the effect of optical stimulation with different waveforms on the brain activity. To break the longitudinal …
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New Forms of Defect Engineering in Silicon and Metal Oxide Semiconductors
… mechanisms involving surface chemistry and optical stimulation. In the present work, the science base describing the surface and optical phenomena, observed in silicon, is placed on firmer ground, and to show more specifically how they might be employed usefully in practical applications …
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Advanced Methods for Defect Engineering in Silicon
… mechanisms: the use of surface chemistry and optical stimulation on boron diffusion and activation during thermal annealing for ultrashallow junction formation. The work has a strong focus on the use of mathematical modeling to better understand the mechanism of boron diffusion, and utilizes …
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Wireless tools for neuromodulation
… refractory or drug resistant. Vagus nerve stimulation (VNS) and deep brain stimulation (DBS) are the only FDA approved device based therapies. Neither therapy offers complete seizure freedom in a majority of users. Novel methodologies are needed to better understand mechanisms and chronic …
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Multifunctional Polymer Fiber Probes for Biomedical Application
… we developed T-DOpE (Tapered Drug delivery, Optical stimulation, and Electrophysiology) probes and Tetro-DOpE (Tetrode-like Drug delivery, Optical stimulation, and Electrophysiology) probes that can simultaneously record and manipulate neural activity in behaving rodents. Taking advantage of …
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ELLIE - Exteroceptive Light Locomotion in Eukaryote-Fungi
… </em>sporocarps under red, green, and blue optical stimulation. Light is applied to the sporocarps, the resulting electrical responses are recorded, and these signals are transmitted wirelessly to actuate the mobile robot. Both the action potential-like activity patterns and the robot’s …
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Opto-mechanical control of nerve growth
… neurotrophic factors, topography, and electrical stimulation have been proposed to enhance nerve growth. This thesis explores optogenetic neural stimulation as a means to control neurite growth that promises greater cell-type specificity than commonly used electrical stimulation. Using dorsal root …
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On the development and application of a photon counting imaging system for broad spectrum luminescence analysis
… incorporating both thermal and multi-source optical stimulation, and providing flexible facilities for the optical filtering of signals, was designed and constructed. Capable of high quantum efficiency, low-noise imaging from infrared to near UV (~ 1050 - ~ 200 nm), the PCIS is based on a …
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On the development and application of a photon counting imaging system for broad spectrum luminescence analysis
… incorporating both thermal and multi-source optical stimulation, and providing flexible facilities for the optical filtering of signals, was designed and constructed. Capable of high quantum efficiency, low-noise imaging from infrared to near UV (~ 1050 - ~ 200 nm), the PCIS is based on a …
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Characterization and connectorization of optoelectronic neural probes
… of flexible polymer and polymer composite neural stimulation and recording systems. Furthermore, recent advances in optical neural stimulation methods would benefit from seamless integration of optical waveguides into neural probes. In this thesis, we describe electronic and optical …
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Modulation of hippocampal synaptic transmission by the peptide diazepam binding inhibitor and optogenetic manipulation of astrocytes
… is modulated by both DBI and by optogenetic stimulation of local astrocytes. Chapter 2 investigates the role of DBI in modulating hippocampal synaptic inhibition using a constitutive DBI knockout animal. Chapter 3 continues to use the DBI knockout animals to examine the role of DBI in …
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Customizing Multifunctional Bidirectional Neural Interfaces through Fiber Drawing
… polymer waveguides for concurrent electrical and optical neuromodulation. To address this challenge, three fabrication approaches based on fiber drawing were introduced. Each method delivered multifunctional probes featuring a low-loss transparent waveguide for optical stimulation, low-impedance …
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Serotonergic Circuits Mediating Stress Potentiation of Addiction Risk
… potentiated subsequent cocaine CPP, whereas optical inhibition of the VGluT3+ neurons blocked subsequent cocaine CPP. SERT+/VGluT3- expressing neurons were concentrated in the lateral aspect of the DRN. SERT projections from the DRN were observed in the medial nucleus accumbens (mNAc), but …
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INFRARED NEURAL STIMULATION AND FUNCTIONALRECRUITMENT OF THE PERIPHERAL NERVE
… neuron. Neural interfaces based on electrical stimulation of neurons have made the most progress in restoring movement in paralyzed limbs, but increasing selectivity without increasing invasiveness remains a primary goal in developing stable and chronic nerve interfaces. Interfaces that use …
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Technology development for studying information flow in biological neural networks
… of electrophysiological recording devices and optical stimulation devices for studying the information. How along the neural network in the brain. Specifically, it concentrates on the penetrating microelectrode array and the micro-sized light emitting diode (µLED) coupled glass optrode array …
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Biofabrication of muscular and neuronal in-vitro tissue for multi-cellular engineered living systems
… well as Channelrhodopsin, to enable optogenetic stimulation of these neurons, which was used to design the training regimens. Past efforts have not considered reprogramming in terms of evoking long-term changes in firing patterns of in-vitro networks by training regimens during stages of neural …
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Interrogation and control of mammalian transcription
… gene expression (Konermann et al. Nature 2013). Optical stimulation enables precise spatiotemporal control to closely match endogenous transcriptional dynamics. I engineered the LITE system based on the programmable TALE DNA binding proteins from plant pathogens in combination with the …
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Software pro měření reakční doby při optické stimulaci
Tato práce se zabývá měřením reakční doby na základě optické stimulace, rozebírá teorii vidění, metody měření reakční doby, řeší návrh a realizaci aplikace pro měření reakční doby, archivaci výsledků měření a jejich statistické vyhodnocení. Pojednává o měření reakční doby s využitím vytvořené …