Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Optical Biopsy"”.
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Optical biopsy of in vivo tissue using optical coherence tomography
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1997.
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Quantification of the Distribution of Forward and Backscattered Second Harmonic Generation by Collagen for the In Vivo, Optical Biopsy of Skin Cancer
… aid in the progress of developing a non-invasive optical biopsy based on endogenous fluorescence and non-linear light scattering that can be used to detect skin cancer. A trial was conducted that followed 30 UV- and sham-exposed SKH1 mice over a 6-month period. Collagen images were obtained by …
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In Vivo Assessment of the Forward to Backward Ratio of Second Harmonic Generation By Collagen As Part of a Non-Invasive, All-Optical Biopsy for Skin Cancer
… indicate pathology in skin. SHG, a non-linear optical process where two near-infrared photons of a certain energy are converted to one UV photon of twice the energy at a non-centrosymmetric molecule such as collagen. It has been demonstrated that the forward-to-backward scatter SHG ratio is …
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Discriminating benign from malignant thyroid nodules in real-time using a novel probe with an integrated elastic scattering spectroscopy biopsy syringe
… standard of diagnosis, fine needle aspiration biopsy (FNAB) yields indeterminate results for approximately 10–25% of biopsies, necessitating thyroidectomy for diagnosis. Elastic scattering spectroscopy (ESS) is a minimally invasive optical biopsy technique that is sensitive to cellular and …
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Minimally invasive diagnostic imaging using high resolution Optical Coherence Tomography
… characterize and understand biological systems. Optical Coherence Tomography (OCT) is a high speed, high resolution imaging technique that utilizes low coherence interferometry to perform cross-sectional tomographic imaging of tissue in real time and in vivo. The design, development, and …
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Enhanced visualization of retinal pathologies with ultrahigh resolution optical coherence tomography
… damage can either be prevented or delayed. Optical coherence tomography (OCT) is an emerging medical diagnostic technology being investigated for applications in a number of medical fields including ophthalmology, cardiology, and gastroenterology. OCT is analogous to ultrasound except that …
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High speed swept source optical coherence tomography handheld instrument at 1310nm for point-of-care imaging
Optical coherence tomography (OCT) is a novel biomedical imaging technique that functions as a type of "optical biopsy" by using low coherence interferometry to non-invasively generate high resolution cross-sectional images of tissue in real time. OCT has become a standard diagnostic tool in …
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Development of high-speed two-photon microscopy for biological and medical applications
… in neuronal imaging, tumor physiology study, and optical biopsy. A practical limitation of TPM is its slow imaging speed (0.3 1 frames/s). We designed high-speed two-photon microscopes (HSTPMs) whose imaging speed is more than 10 times faster than traditional TPM, while their imaging depths, image …
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Endovascular Optical Coherence Tomography Imaging in Cerebrovascular Disease
… innovation and device development. Endovascular optical coherence tomography (OCT) is the highest resolution intravascular imaging modality available, utilizing near-infrared light with a wavelength of approximately 1300 nm and excellent spatial resolution of 10µm is achievable. With near …
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High resolution imaging of neoplasma using optical coherence tomography
… possible and thus improve patient prognosis. Optical coherence tomography (OCT) can achieve resolutions in the cellular and subcellular range (1-15 [mu]m) and could improve the diagnostic range of clinical imaging procedures. The research described in this thesis includes the ex vivo imaging …
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Development of Novel Instrumentations and Algorithms for Optical Screening of Epithelial Dysplasia
… low-coherence interferometry (a/LCI) is an optical technique which enables depth-resolved measurements of nuclear morphology, a biomarker for precancer. In this dissertation, several advances in a/LCI technology were presented. First, computational analysis of a previous clinical a/LCI …
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A surgical confocal microlaparoscope for real-time optical biopsies
The first real-time uorescence confocal microlaparoscope has been de- veloped that provides instant in vivo cellular images, comparable to those provided by histology, through a nondestructive procedure. The device in- cludes an integrated contrast agent delivery mechanism and a computerized depth …