Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"Opsins"”.
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The Opsins and Nuclear Receptors of the Honey Bee
… In the first study, a novel lineage of insect opsins is described based on the identification of a novel opsin gene, pteropsin, in the honey bee. This novel lineage of insect opsins is more closely related to the vertebrate visual opsins than to invertebrate opsins. The detailed mapping of the …
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Structural, molecular and functional characterisation of visual photoreceptors and opsins in sole: an ontogenetic, chronobiological and environmental approach
La metamorfosis de los peces planos está acompañada de cambios drásticos, que determinan una reorganización total del cuerpo, una remodelación cráneo-facial y la migración de los ojos hacia el lado ocular superior, que transforma a las larvas simétricas en juveniles asimétricos. Durante la …
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Multiphoton imaging and control of opsins in living neural systems by spectral-temporal modulation of a supercontinuum source
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-08-01
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Molecular Evolution of Visual System Genes in Fishes
… of evolutionary studies on two gene families, opsins and crystallins. Opsin proteins determine the wavelengths of light detected by the retina, while crystallin proteins contribute to lens transparency and refractory power. My studies focus on teleost fishes, because teleost visual ecology is …
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Chemosensory gene expression analysis in the argentine ant, linepithema humile
… levels in all the body regions analyzed and that opsins would be highly expressed in the head/antennal region since they are photoreceptors in the eyes. The qPCR results demonstrated that the Ors and opsins were highly expressed in the head/antennal samples compared to the thorax/legs and …
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Independent two-color optogenetic excitation of neural populations
The optical modulation of neurons with channelrhodopsins, a class of genetically encoded light-gated ion channels, has enabled the spatiotemporally precise interrogation of the roles individual cell types play in neural circuit dynamics. A topic of great interest to the neuroscience community is …
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The role of photoreceptors in human skin physiology; potential targets for light-based wound healing treatments. Identification of opsins and cryptochromes and the effect of photobiomodulation on human skin and in cultured primary epidermal keratinocytes and dermal fibroblasts
… Emerging new molecular targets include the GPCRs opsins (OPNs) and the circadian clock transcription factors, cryptochromes (CRYs). Localisation of OPN1-SW, OPN3, OPN5, CRY1 and CRY2 was seen in female facial and abdominal human skin. Furthermore, expression of these photoreceptors was retained in …
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Molecular Evolution and Functional Characterization of the Visual Pigment Proteins of the Great Bowerbird (Chlamydera nuchalis) and Other Vertebrates
… and phylogenetic recreation of ancestral opsins. While cone opsins mediate colour vision in bright light, the rhodopsin visual pigment contained in rod photoreceptors is critical for dim light vision. Detailed characterization of rhodopsin function has only been conducted on a few model …
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Femtosecond pulse shaping for enhanced optical imaging and control of cells
… fluorescent molecules, caged compounds, and opsins.
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FLEXIBLE GEL IMPLANT LOADED WITH PERSISTENT LUMINESCE NANOPARTICLES FOR PHOTOTHERAPY IN DEEP TISSUES
… photodynamic therapies, as they cannot activate opsins and photosensitizers. To overcome this, nanotransducers converting X-rays to UV/visible light are used. Among them, X-ray activated persistence luminescence nanoparticles (PLNPs) gained interest. PLNPs emit light continuously for several …
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Visual Opsin Diversity in Anurans
… techniques, sequences were obtained for four opsins—the protein component of visual pigments—expressed in anuran retinas. Amino acid sequences of the genes RH1, LWS, SWS1, and SWS2 were compared across taxa to identify variable sites, as such variation can shift the spectral sensitivity of …
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Re-examining the relationships among families of Pectinoidea and molecular machinery of the visual cycle in molluscs
… relationship between genotype and phenotype in opsins by mutating targeted amino acids of interest and examining how these alternations affected opsin function when expressed in vitro. Comparing two closely related scallop retinochromes, I identified and mutated sites lining the binding pocket …
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Development of next-generation optical neural silencers
… pumps. We characterized a number of novel opsins through an exploration of ecological and genomic diversity, and further boosted opsin function and trafficking through the appendage of signal sequences. The green-light drivable archaerhodopsin-3 (Arch) from Halorubrum sodomense and the …
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Controlling Arrhythmias Using Optogenetic Actuators in Computational Simulations
… a basic explanation of optogenetic actuators (opsins), covering past applications (both experimental and computational) in cardiac tissue at various scales. Chapter 3 examines the efficacy of expressing an anion-conducting opsin (GtACR1) to terminate atrial and ventricular arrhythmias in 3D …
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Environmentally Influenced Duplication Patterns Followed by Functional Shifts Fueling the Evolution of Metazoan Sensory Systems
… on the duplication and neofunctionalisation of opsins in animals as a result of environmental signals, leading to the evolution of colour vision. This study of vision is expanded upon in chapter three by looking at how the duplication of an entire visual pathway has led to the emergence of a new …
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Acetabularia-Rhodopsin, eine lichtgetriebene Protonenpumpe aus einem autotrophen Eukaryoten
… Sequenz, das gesamte Transkript eines Opsins in Form komplementärer Desoxyribonukleinsäure isoliert, kloniert und sequenziert. Das aus der abgeleitete Aminosäurensequenz resultierende hypothetische Protein hat eine mit den Rhodopsinen des Typs 1 übereinstimmende Primär- und …
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Noninvasive optical inhibition with a red-shifted microbial rhodopsin
… photocurrents than other inhibitory opsins. I describe the design process involved in engineering Jaws, as well as its characterization in vitro, ex vivo, within the awake in vivo rodent brain, and in transgenic mice. Jaws exhibits robust inhibition of sensory-evoked neural activity …
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FTIR study of carboxylic acids and tyrosines in bacteriorhodopsin
… the general structure-function relationship of opsins.
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Evolution and functional specializations in nocturnal environments: insights from visual pigments in Chiroptera
… long-term shifts in selection constraint in cone opsins occur in response to ecological factors underlying reliance on visual information and exposure to varying light environments. In Chapters 4 and 5, I focus my study on the evolution of the dim-light visual pigment rhodopsin (Rh1) in response …
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Comparative genomics of early animal evolution
… among the GPCR families: the Opsin family. Opsins are key proteins used in the process of light detection, and the origin and early evolution of this family are still substantially unknown. Chapter 4 addresses both these problems. The thesis is then concluded by a general discussion (Chapter …
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