Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 66 for “"Opportunistic infections"”.
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Opportunistic infections in Edinburgh AIDS patients: 1984-1994
… features and outcome of major AIDSrelated opportunistic infections in a cohort of HIV-seropositive patients attending Edinburgh's City Hospital between 1984 and 1994. To determine which clinical features are ofprognostic significance in opportunistic infections and the effect of …
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Retrospective analysis of outcomes in the programme of fast-tracking of antiretroviral therapy for patients admitted to a palliative care centre after diagnosis of opportunistic infections
… of 200 cells/uL, immediate ART initiation after opportunistic infection (OI) treatment in the inpatient wards at several international sites has been shown to reduce the adverse outcomes of AIDS progression and death. Current South African policies of discharging patients after hospital admission …
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Seroprevalence of anti-toxoplasma IgG antibody in HIV patients with neurological manifestations
… complications of HIV disease secondary to opportunistic infections are significantly common. At least one third of patients with advanced HIV disease will present with neurological complications possibly secondary to opportunistic Infections such as Cerebral Toxoplasmosis. In patients with …
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Assessment of Gamma/Delta T Cell Functionality Following Pathogenic HIV/SIV and Non-Pathogenic SIV Infections
… gamma/delta (gamma delta ) T cells) leading to opportunistic infections. gamma delta T cells bridge the innate and adaptive immune responses primarily via cytokines produced in response to microbial phosphoantigens. gamma delta T cells have also been implicated in the control of an SIV challenge …
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An assessment of Hypoxis hemerocallidea extracts, and actives as natural antibiotic, and immune modulation phytotherapies
… hemerocallidea is used by AIDS patients to treat opportunistic infections, such as tuberculosis. The rapid emergence of multidrug-resistant tuberculosis, and extreme drug resistant tuberculosis, in recent years, is a major threat to human health. The treatment of TB, nosocomial bacterial …
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TARGETING MULTI-DRUG RESISTANT PATHOGENS WITH NOVEL ANTIMICROBIAL PEPTIDES
… around 23,000 patients each year. Half of these infections are attributed to the bacterial pathogen, methicillin resistant Staphylococcus aureus (MRSA) according to a report published in 2013 by the Centers for Disease Control and Prevention (CDC). Similarly, S. pseudintermedius is a leading …
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The role of inflammation, oxidative stress and the apolipoprotein E genotype in HIV-associated cognitive impairment: a clinical, biochemical and neuro-imaging study
… as opposed to neurological diseases secondary to opportunistic infections in the immune compromised host. Our study investigated the role of systemic markers of inflammation and oxidative stress, inflammatory changes in the brain on magnetic resonance spectroscopy (MRS) and the role of the APOE E4 …
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Early Events Following Oral Transmission of Simian Immunodeficiency Virus: From Viral Entry to Host Immune Response
… chronic infection would prevent the onset of opportunistic infections. My data support hypothesis one, as during early times post-infection (2 - 21 days), gingival mucosal innate response gene expression correlated with the ability toinduce timely SIV antibodies and reduce plasma viral loads. …
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Burden of antituberculosis and antiretroviral drug-induced liver injury at a secondary hospital in South Africa
… on multiple hepatotoxic drugs, may have multiple opportunistic infections, systemic sepsis and hepatic TB immune reconstitution disease also plays a role. Anecdotally, these patients are complex to manage, require frequent specialist input, spend a long time in hospital and have high mortality. …
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The impact of the SARS-COV-2 pandemic on maternal mortality in a South African Metropole (2020-21)
… Folder review of deaths revealed an increase in opportunistic infections as a cause of death relative to pre-pandemic. Conclusion: Whilst maternal healthcare services were largely protected from service disruptions during the COVID-19 pandemic, there was a reversal of some of the progress made in …
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Pharmaceutical pricing : assessing the impact of factors influencing HIV/AIDS and AIDS related medicine prices in Zimbabwe
… deaths in the country. However high AIDS and opportunistic infections drug prices have rendered these medicines unaffordable and inaccessible to the vast majority of the population infected with the virus. Moreover the majority of the population has to meet most of its drug cost through out of …
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Barriers to oral health care among people living with HIV in Kwazulu Natal and the Western Cape
… infected with HIV. Oral lesions and various opportunistic infections characterize the progression of HIV making it imperative for people living with HIV to have access to good quality oral care. There is a need to examine accessibility and use of dental services in South Africans living with …
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Materia medica and care : a study of the uses of medicinal herbs and remedies as a form of treatment and negotiating social relationships in Cape Town and surroundings
… for the treatment of HIV and symptoms of related opportunistic infections such as tuberculosis, thrush and shingles in the Western Cape. The study stems from twelve months fieldwork in Strand, Western Cape and the collection of plants from Mpoza, Eastern Cape for a variety of reasons. The study …
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Enzyme Mediated Gentamicin Resistance Among Gram-Negative Clinical Isolates
… treatment of serious gram- negative bacillary infections (1-5). Gentamicin is one of the few antimicrobial agents available for the treatment of life- threatening infections due to Pseudomonas aeruginosa (114-116), an organism of increasing etiological significance in opportunistic infections …
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Enhancing T-Cell Responses to Vaccination of HIV-1 infected Subjects on Antiretroviral Therapy
… individuals infected with HIV-1 at risk from opportunistic infections and co-morbidities. Furthermore, a therapeutic HIV-1 vaccine is needed that can elicit responses to help infected subjects better control HIV infection so as to potentially reduce the need for long-term therapy. However, …
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HIV/AIDS in South Africa : Towards a New Paradigm
… of the immune system, leaving it vulnerable to opportunistic infections and disease of increasing severity resulting in inevitable death. Virology identified the virus that is the infectious agent and provided explanations of how it had its effect on the host, reproduced and was transmitted. …
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Design, synthesis, and evaluation of release kinetics of novel LFA-1 and TLR-4 inhibitor prodrugs for localized immunomodulation.
… toxicity and leave the recipient vulnerable to opportunistic infections. Localized immunosuppression, inhibiting immune responses against the transplant graft in a localized region while maintaining wider immune system function is therefore a topic of interest. This dissertation details the …
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Quantitative measurement of body composition in individuals with acquired immune deficiency syndrome (AIDS)
… - Kaposis sarcoma (KS), and HIV positive -opportunistic infections (OI). The major conclusions derived from this study were based on the evaluation of body weight (BW) , body fat (BF) and body cell mass (BCM) alterations that were directly measured. Values for extracellular supporting …
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Identifying Pantoea Genetic Factors Involved in Host Association by Integrating Comparative Genomics with a Dictyostelium discoideum Grazing Resistance Model
… in humans, despite numerous reports of clinical infections. This thesis aims to identify genetic factors that could contribute to host association and thus, opportunistic infections by Pantoea. Chapter 1 provides a broad literature review of Pantoea, opportunism and virulence, model systems to …
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Surface proteins of Finegoldia magna interacting with the human host
… human microflora. This bacterium is also an opportunistic pathogen and isolated from ~10% of all anaerobic infections. Reoccurring taxonomical changes and the anaerobic growth have contributed to the neglect of F. magna. The present thesis describes the identification and characterization of …
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