Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 35 for “"Opn"”.
-
Studies in beta cells and adipocytes in the context of obesity and T2D - focusing on PDE3B, OPN and SCFAs
… and dysregulated insulin secretion, show induced OPN protein expression. In addition, in silico and functional approaches demonstrate that PDE3B and OPN are connected and follow a similar protein expression pattern in response to e.g. cAMP-elevating agents and insulin. Little is known regarding …
-
Expression and function of osteopontin variants in HCV-related liver disease and hepatocellular carcinoma.
Osteopontin (OPN) is a highly secreted multi-functional sialoprotein that is widely expressed in tissues, blood and urine. It is involved in a number of normal physiological functions, but is also significantly elevated in a number of cancers. While OPN is significantly expressed in hepatocellular …
-
Expression and Regulation of Osteopontin in the Diabetic Heart
… factor in most cardiac pathologies. Osteopontin (OPN) is a small phospho-protein that has been implicated in fibrotic tissue remodeling. In the heart, the expression of OPN protein is increased after acute and chronic pathologies. Upregulation of OPN coincides with a transition to heart failure …
-
Investigations into the Neuroprotective Effects of Osteopontin in In Vitro and In Vivo Models of Parkinsons Disease
Osteopontin (OPN), a glycosylated phosphoprotein found in brain, is reduced in the surviving dopamine-containing neurons in the SN (SN) in Parkinson’s disease (PD). OPN prevents the death of dopaminergic neurons in cell culture and animal models of PD. This effect may be mediated through …
-
Effects of supplemental osteopontin on intestinal development and serum antibody responses to rotavirus vaccination in piglets
… growth and mucosal immunity include osteopontin (OPN). Osteopontin is a phosphorylated acidic glycoprotein expressed by a number of different immune and non-immune cells and tissues (Sodek et al., 2000). It is also present in body fluids including blood, bile and milk (Sodek et al., 2000). …
-
The Function and Regulation of Senescent Stromal-Derived Osteopontin
… secreted multifunctional protein osteopontin: OPN) as a critical stromal mediating factor. RNAi-directed reduction of stromal OPN leads to decreased growth of preneoplastic keratinocytes in vitro and in vivo. Furthermore, I have demonstrated the presence of senescent stroma and associated OPN …
-
Einfluss der Osteopontin Defizienz bei Mäusen auf allergische Hautreaktionen vom Spättyp
Osteopontin (OPN) ist ein von Immunzellen sezerniertes, saures Phosphoprotein. In <br>verschiedenen Modellen konnte eine Th1-Zytokinartige Wirkung von OPN nachgewiesen <br>werden. Kürzlich wurde gezeigt, dass OPN während der Sensibilisierungsphase einer <br>Kontaktallergie in der Haut und in den …
-
Corrélation of Plasma Osteopontin Levels and 3D US Imaging with Tumor Response to Neoadjuvant Therapy
… response: measurement of plasma osteopontin (OPN) levels and three dimensional ultrasound imaging (3D US). Using our laboratory’s in house ELISA, we found that 39% of LABC patients had plasma OPN levels elevated above the normal healthy range of I23ng/ml (Bramwell,20o6). Over treatment this …
-
A meta-language for systems architecting
… engineering systems, the research applied OPN to two space exploration programs and one aircraft design problem. In our experiments, OPN was able to significantly change the modeling and architectural reasoning process by automating a number of manual model construction, manipulation, and …
-
Molecular and Cellular Mechanisms of the Angiogenic Effect of Poly(methacrylic acid-co-methyl methacrylate) Beads
… also appeared to modulate the expression of OPN. In vivo, the global gene expression of OPN was increased in wounds treated with MAA beads, compared to PMMA and no beads. In contrast, dTHP-1 decreased OPN gene expression compared to PMMA and no beads, but expressed the same amount of secreted …
-
Osteopontin and Cadherin 11 Are Novel Mediators and Drug Targets For Chronic Lung Diseases
… adenosine-dependent expression of osteopontin (OPN). OPN is a protein implicated in a variety of human pathology, but its role in COPD has not been examined. To address this, Ada/Opn -/- mice were generated and endpoints consistent with COPD were examined in parallel with Ada -/- mice. Results …
-
A különböző koncentrációban alkalmazott aerogél kompozit hatása bölcsességfog apikális papillájából származó őssejtekre
… sejtek proliferációját, a BMP-2 és oszteopontin (OPN) gének expresszióját emelte, azonban az ALP gén expresszióját és aktivitását gátolta. A 0,1 mg/ml-es szuszpenzió kisebb mértékben, de szintén gátolta az ALP gén expresszióját és aktivitását. A sejtek proliferációját és a BMP-2 gén expresszióját …
-
Neuroprotective Molecules and Strategies in a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy
… stimulating factor (G-CSF), and osteopontin (OPN) in reducing apoptosis and inflammation following neonatal hypoxic ischemic encephalopathy and have outlined the cellular pathways involved in their abilities to provide neuroprotection. Our work showed that intranasal administration of IFNβ was …
-
Diabetic Vascular Complications & Inflammation - role of NFAT and TNFalpha
… of the pro-inflammatory cytokine osteopontin (OPN). Furthermore, plasma levels of OPN have been shown to correlate to the progression of diabetic nephropathy and retinopathy. Using the NFAT inhibitor A-285222 and NFATc3 deficient mice, we provide evidence that hypeglycemia-induced OPN …
-
Stress Conditioning and Heat Shock Protein Manipulation for Bone Tissue Engineering
… rapidly induced osteocalcin (OCN), osteopontin (OPN), osteoprotegerin (OPG), vascular endothelial growth factors (VEGF), and cyclooxygenase 2 (COX-2) mRNA at 8 hour post-heating (PH). The addition of GFs with heating induced OPG and VEGF genes more than heating or GF addition alone. OPN, OCN, and …
-
Object-process networks & object-process diagrams : implementation issues for oil exploration systems
… different ways to increase the ability of OPN (Object-Process- Network), a system-architecture meta-language, to model complex systems and identify architectures to address those systems. It proposes ways to generate "out-of-the-box" solutions to technical problems, to weight a portfolio of …
-
Osteogenesis During Early Healing Around Titanium and Titanium Zirconium Implants: Immunohistochemistry and mRNA Expression of Bone Markers in Miniature Pigs
… The presence of B-catenin, Runx2, Osteopontin(Opn), and Osteocalcin(Ocn) were measured by IHF. RNA was isolated from two animals at 2 weeks; Osterix(Osx), Opn and Ocn mRNA expression levels were evaluated for osteoblasts differentiation by QRT-PCR. <strong>Results: </strong>No significant …
-
Expression und Regulation 1,25(OH) 2 -Vitamin D 3-responsiver Gene in monozytären Zellen
… Gen wurde die Expression von Osteopontin (OPN) untersucht. OPN ist ein vor allem in Knochen vorkommendes Matrixprotein, das wesentlich an der Zelladhäsion beteiligt ist. OPN wird in THP1-Zellen im Zuge der Differenzierung zunehmend exprimiert. Durch immunhistochemische Untersuchungen konnte …
-
Fuzzy Decision Support Applied to Machine Maintenance
… optimal perimeter of the neighbourhood (LAIVFDT-OPN) model, and high-order type-2 fuzzy time series (HO-T2FTS) model. In the experiment with a real world business, a ‘computerised maintenance integration management system’ (CMIMS) is constructed as a simulation model for a case study. The CMIMS …
-
Gelatin nanoparticles for improved neuroprotection of intranasally delivered osteopontin in ischemic stroke
… victims receive medical attention. Osteopontin (OPN), a ubiquitous protein with roles in cell migration, inflammation, and apoptosis, has been shown to confer neuroprotection following ischemic stroke in animal models. In this work, we not only successfully fabricated GNPs with a uniform shape, …
Page 1 of 2