Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 226 for “"Opioids"”.
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Development and Applications of Opioids Alternatives for Pain Management
… alternative pain management strategies to opioids, focusing on tetrodotoxin (TTX) and capsaicin as novel anesthetics. Acute post-surgical pain typically lasts 5-7 days, while long-term pain management can span up to 12 weeks. Opioids are commonly used but are linked to serious side effects, …
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Factors associated with co-prescription of opioids and gabapentinoids
… system, especially when co-prescribed with opioids. The rates of prescribing gabapentinoids have significantly increased over the last decade. However, limited research has investigated the impact of excessive prescribing, and the factors associated with the co-prescribing of opioids and …
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Neuroimmune and Developmental Mechanisms Regulating Motivational Behaviors for Opioids
<p>Opioid drug abuse represents a serious public health concern with few effective therapeutic strategies. A primary goal for researchers modeling substance abuse disorders has been the delineation of the biological and environmental factors that shape an individual’s susceptibility or resistance …
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The Impact of Opioids and Opiates on Adult Hippocampal Neurogenesis
… mouse hippocampus. Here, I show that endogenous opioids may act through the mu opioid receptor (MOR) to similarly decrease survival of new hippocampal neurons. An exon 1 MOR knockout mouse showed increased survival of new neurons independent of effects on cell proliferation or cell death. In …
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Determinants and Effectiveness of Nonpharmacologic Pain Interventions Versus Prescription Opioids
… treatments became more common than prescription opioids beginning in 2015 among adults with chronic, but not surgical, pain. Secondary findings from Aim 1 suggested that disparities—based on race, education, and income—impeded access to pain treatments. The Agency for Healthcare Research and …
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Nursing Students’ Knowledge and Attitudes About Pain Management and Opioids
… healthcare professionals’ knowledge of using opioids for pain management safely is critical in preventing opioid abuse and overdose. Undergraduate curricula of health professional schools, including undergraduate nursing programs, need to improve and adopt a comprehensive education regarding …
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Euphoria: The Transition from Prescription Opioids to Heroin in Kentucky
… demand for and availability of prescription opioids has been quite prevalent in the state of Kentucky primarily since the early 1990's. But between 2010 and 2012, reformulations of opioids OxyContin and Opana, along with the passing of HB 217 and mandatory KASPER (Kentucky All Schedule …
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Assessing Concurrent Use of Opioids and Benzodiazepines Using Urine Drug Test Results
… to assess concurrent use of benzodiazepines and opioids, using laboratory results from urine toxicology records. The opioid crisis is an ongoing public health issue that has spanned over two decades. Drug overdose death is now the leading cause of accidental deaths among American adults. Patients …
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Fragmented maternal care programs altered pain vulnerability and aberrant responses to opioids
… pain resilience and/or behavioural responses to opioids, perhaps contributing to the increased prescribing and misuse of opioids. <br/><br/>Mu opioid receptors (MOP), delta opioid receptors (DOP), β-arrestin 2 (Barr2) and c-Src kinase are all components of the opioid signalling system, which to …
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Neuropsychological function as a result of chronic exposure to methadone and other opioids
… increasingly recognised that chronic exposure to opioids has been associated with neuropsychological impairment during both active use and following a period of abstinence. The overall objective of this thesis was to review the relevant prior literature in a systematic manner and subsequently to …
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COMPARATIVE EFFECTS OF GABAPENTINOIDS VS OPIOIDS ON FRAILTY AND PHYSICAL FUNCTION AMONG MEDICARE BENEFICIARIES
The use of opioids in the treatment of chronic non-cancer pain has been the standard pharmacological option for many years. With the concern over the opioid epidemic, effective pain relief alternatives have been sought. Recently, gabapentinoids have increased in use, specifically as a substitute …
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Association of incident gabapentin use: with long-term use of opioids, benzodiazepines and Z-drugs
… is misused when taken with other drugs, such as opioids, benzodiazepines (BZD) and Z-drugs. Although gabapentin is considered safe when used alone, concomitant use with the aforementioned drugs is dangerous and increases the risk of overdose. The aim of this research was to investigate the …
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Intra-nacc adenosine and its role in mediating palatable food intake: interactions with striatal opioids
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Striatal adenosine is believed to have a significant modulatory role over a variety of striatal circuitry and associated psychomotor and feeding behaviors. However, it is currently unknown to what extent striatal adenosine …
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Enhancing the use of opioids in pain management: antinociceptive potentiation with opioid agonist/antagonist combinations.
While opioids are the most effective and widely used class of drug for the management of moderate to severe pain, their use may be limited by adverse effects that are unpleasant and potentially dangerous. Research is increasingly directed towards strategies to improve the use of opioids in pain …
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Ultra-Low Dose Antagonist Effects on Cannabinoids and Opioids in Models of Pain: Is Less More?
… opioid receptor system, by looking at whether opioids and cannabinoids interact at the ultra-low dose level, whether cannabinoid receptors themselves demonstrate the ultra-low dose antagonist effect, and whether the opioid ultra-low dose effect is maintained in a model of persistent, …
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Experiences and Perceptions of Rural Postpartum Women With Substance Use Disorders Inclusive of Opioids Regarding Their Care
<p>Perinatal opioid use and neonatal withdrawal continue to rise rapidly in the face of the growing epidemic of opioid addiction in the United States, with rural areas more severely impacted. Despite several decades of research and development of practice guidelines, maternal and neonatal outcomes …
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Regulation and site of action of exogenous and endogenous opioids on growth hormone and prolactin secretion in Holstein calves
… and site of action of exogenous and endogenous opioids on pituitary growth hormone (GH) and prolactin (PRL) secretion in Holstein calves. In the first study, the effect of the opioid agonist DAMME (D-Ala²⁺,N-Me-Phe⁴,Met(O)⁵-01 enkephalin) on plasma GH and PRL secretion was measured in Holstein …
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A Systematic Investigation of Whether Cannabinoids and Opioids Interact in the Nucleus Accumbens Shell to Differentially Impact Feeding Patterns on a Palatable Diet
Systemically administered cannabinoids and opioids have been shown to synergistically impact eating in the rat. Pharmacological manipulations of both cannabinoids and opioids in the nucleus accumbens appear to differentially impact eating. Therefore, the nucleus accumbens may be one neural location …
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