Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"Opioid-induced hyperalgesia"”.
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Comorbid opioid dependence and chronic pain: Clinical implications
<b>Context</b>: Chronic pain and opioid dependence confer substantial individual and societal burdens and are notoriously difficult to treat effectively. Their comorbid presentation further complicates effective treatment through complex physiological and environmental …
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Codeine, heightened pain sensitivity and medication overuse headache: a neuroimmune hypothesis and novel treatment strategy.
Codeine is the most widely consumed opioid analgesic worldwide. It relies upon partial metabolism to morphine to elicit analgesic effects. Paradoxically, the pain-reliever morphine has previously been linked to states of increased pain sensitivity; such as medication overuse headache and …
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CaMKIIbeta in Pain and Addiction
… delves into understanding CaMKIIβ in pain and opioid addiction. Looking to reveal if CaMKIIβ is involved in inflammatory and neuropathic pain, I studied the evoked pain behavior of CaMKIIβ global knockout mice (KO) following Complete Freund’s Adjuvant (CFA) injection and Spared Nerve Injury …
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Increased Microglial Reactivity Alters Morphine Analgesia
Opioids are a potent class of analgesics in the management of both moderate to severe acute pain and chronic pain. Although neuronal response to opioids is well described, we are lacking a complete characterization of the diverse interplay of neurons with other cells types in response to opioids. …
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Study of alternative splicing events associated with hyperalgesia
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2023-12-01
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Yoga Therapy for Chronic Pain in Sickle Cell Disease
… acute and chronic pain is largely managed with opioids, but these medications have significant side effects including dependence and potential for opioid-induced hyperalgesia. There is an expert recommendation to avoid chronic opioid therapy if possible, but unfortunately this leaves clinicians …