Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Opioid system"”.
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Social trauma and the mu-opioid system in depression
… under investigation is that the endogenous opioid system plays a key role in depression subsequent to traumatic childhood social experiences. This is suggested by the fact that animal work indicates that mu-opioids robustly mediate separation-distress, and that early social stressors lead to …
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The role of the endogenous opioid system in thermoregulation during exercise
… physical exercise stresses the thermoregulatory system, particularly if hot, humid environmental conditions prevail. It has recently been postulated that endogenous opioids may play a role in regulating body temperature at rest and because it has also been shown that blood levels of these …
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The effects of chronic intermittent ethanol exposure on withdrawal related behaviors, dopamine terminal function and kappa opioid system sensitivity in the nucleus accumbens core
… presynaptic receptor proteins such as kappa opioid receptors (KOR) and dopamine D2/D3 autoreceptors (D2R/D3R), and changes in receptor-system function may, in part, drive symptoms of ethanol withdrawal and subsequent relapse drinking behavior. To this end, the present body of work identified …
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OPIOID ADDICTION AND PREGNANCY: POTENTIAL EFFECTS OF SUBSTITUTION THERAPIES ON DEVELOPMENTAL MYELINATION
While most cells of the central nervous system (CNS) express opioid receptors, the role of the endogenous opioid system in CNS development remains poorly understood. Identification of opioid functions during brain maturation is particularly crucial in light of the increasing trend in opioid abuse …
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The Role of Gonadal Hormones on Opioid Receptor Protein Density in Arthritic Rats
The majority of research on the endogenous opioid system has focused on various pain assays and the efficacy of different opioid agonists. However, minimal attention has been focused on the effects of gonadal hormones and their impact on the opioid peptide system. The present study was designed to …
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Opioid Addiction Treatments During Pregnancy and Their Effects on Axonal Growth and Myelination in the Developing Central Nervous System
… represents a promising alternative for pregnant opioid addicts but there is a need to understand potential effects on nervous system development. We previously showed effects of perinatal exposure to buprenorphine on axonal caliber and myelination in 26-day-old rat corpus callosum. These changes, …
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Diverse Kappa Opioid Receptor Agonists: Relationships Between Signaling and Behavior
<p>The opioid system, comprised mainly of the three opioid receptors (kappa, mu and delta) and their endogenous neuropeptide ligands (dynorphin, endorphin and enkephalin, respectively), mediates mood and reward. Activation of the mu opioid receptor is associated with positive reward and euphoria, …
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Neuropharmacological Mechanisms Underlying Incentive Salience and Stress
… to a role for the mesolimbic dopamine (DA) system in the etiology of motivational deficits. However, the neurobiological mechanisms underlying the manifestation of anhedonic behavior are still not well understood. Given the frequent presentation of anhedonia in stress-related psychiatric …
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The Role of Mu Opioid Receptors in the Behavioral Effects of Cocaine
… cocaine impacts other neurotransmitter systems including the endogenous opioid system. The effects of selectively antagonizing mu opioid receptors on cocaine-induced behaviors were evaluated during this research. This research also evaluated the effect of selectively antagonizing …
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OPPOSING ROLES OF THE μ-OPIOID AND NOCICEPTIN/ORPHANIN FQ RECEPTORS IN OLIGODENDROCYTE DEVELOPMENT AND MYELINATION
… plasticity and remodeling in the central nervous system (CNS). Thus, OLG maturation and myelination are highly vulnerable processes along CNS development. We previously showed that rat brain myelination is altered by perinatal exposure to buprenorphine, an opioid analogue in clinical trials for …
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Oxytocin as a pharmacological tool to curb overeating: Exploring synergy with opioid receptor blockade
… Though each of the many feeding-related neural systems affects the select facets of appetite to a different degree, most basic research (and subsequently, also clinical) studies exploring anorexigenic potential of neuroactive molecules, focus on targeting only one system. This single-system …
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Anorexigenic effects of naltrexone in rats
… preferred and, therefore, overconsumed tastants. Opioids are key neuropeptides that propel feeding for reward. Importantly, blocking the opioid receptors in laboratory animals and humans decreases intake of and preference for those diets that are highly palatable. One of those opioid receptor …