Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 50 for “"Opioid receptors"”.
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The Role of Mu Opioid Receptors in the Behavioral Effects of Cocaine
… systems including the endogenous opioid system. The effects of selectively antagonizing mu opioid receptors on cocaine-induced behaviors were evaluated during this research. This research also evaluated the effect of selectively antagonizing dopamine D1 or D2 receptors on …
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Development of Non-covalent Chemical Probes for μ, δ and κ Opioid Receptors
Opioids are well-known pain relievers and one of several therapeutic options for pain management. Although opioids are very effective analgesics, continued use and abuse can lead to physical dependence and withdrawal symptoms. Their side effects, such as constipation, respiratory depression, and …
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Predicting the Pose of β-Casomorphin-5 and 7 in the Opioid Receptors
The opioid receptors consist of three main subtypes; μ, δ, and κ. Previous binding studies have shown that fragments of the milk protein, β-casein, known as β-casomorphins are agonists of these receptors which are selective for the μ receptor subtype. Using the crystal structures of these three …
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Molecular Characterization of the Opioid Receptors: Design, Development, and Preclinical Evaluation of Salvinorin A-Based Molecular Probes.
… represents a novel and emerging field of opioid research. The novelty is derived from the lead pharmacophore: salvinorin A — a neoclerodane diterpenoid natural product isolated from Salvia divinorum. Salvinorin A represents a pharmacologically unique compound in that it is the first known …
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Early Diagnosis of Alzheimer's Disease and Studying Binding to Opioid Receptors using Whispering Gallery Mode Microtoroid Biosensors
… can be functionalized with antibodies or receptors that specifically recognize biomarkers of interest. As biomarkers bind to the surface bound receptors within the evanescent field, they induce a shift in the resonant wavelength which can be used to quantify the level of biomarkers in a …
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Characterisation of the role of peripheral μ-opioid receptors in the behavioural effects of heroin and their underlying neural systems in the rat
The behavioural effects of opioids such as heroin have long been considered to be mediated by central mechanisms. However in recreational use, opioids are administered systemically and can therefore influence peripheral μ-opioid receptor-dependent systems before they reach the brain. In humans, …
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New paradigm for drug design: Design and synthesis of novel biologically active peptides that are agonists at opioid receptors and antagonists at cholecystokinin receptors
… are clearly evident in neuropathic pain where opioids can actually heighten pain. In these pain states there are increased levels of neurotransmitters such as cholecystokinin (CCK) in which both the peptides and their receptors are increased in pain states. To effectively treat diseases …
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Synthesis of Analogues Based on the Opioid Alkaloid Mitragynine
Opioid analgesics such as morphine and its derivatives are the most frequently prescribed narcotics for the treatment of severe and chronic pain. Among other side effects caused by the administration of these opioid analgesics, physical dependence and addiction are the most undesirable ones. …
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Understanding ligand binding, selectivity and functions on the G protein-coupled receptors: A molecular modeling approach
… profile of naltrexone derivatives on the three opioid receptors (μ-opioid, κ-opioid, δ-opioid) with an aim towards designing selective μ-opioid receptor antagonists, and iii) structural modeling of the ‘active’ state conformation of the κ-opioid receptor in response to agonist binding and …
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Effects of DFO-Induced Hypoxia on Key Signaling Mediators
… associate with hypoxia-induced pain. Clinically, opioids, such as morphine, are used to modulate pain. The mu-opioid receptors (MORs) are one of three main types of opioid receptors and are key mediators in morphine-induced analgesia. Therefore, in this study, the effect of hypoxia on MOR gene …
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Novel Bifunctional Ligands For Neuropathic Pain: Design and Synthesis of Overlapping Pharmacophores of Opioid and Melanocortin Ligands
… target. MC4R based agonist ligands produce anti-opioid effects, and researchers have shown that an antagonist of the MC4R can produce pronounced anti-allodynic effect. Opioid receptors have been the central and most efficacious targets sought after for relieving neuropathic pain. In our new …
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Targeting Opioid Receptor Signal Transduction to Produce Sustained Analgesia
Mu opioid receptors (MOPs) in the pain pathway contribute to morphine analgesia. Morphine also stimulates reward/reinforcement through disinhibition of dopaminergic (DA) neurones in the ventral tegmental area (VTA), an effect implicated in its abuse and dependence. We hope to develop approaches to …
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The role of the large conductance Ca2+-activated K+ channel in adenosine receptor-mediated cytoprotection
… properties to primary cardiomyocytes. Adenosine receptors are well known mediators of cardioprotection and trigger effectors such as the mitochondrial KATP channel – however, the role of the mitochondrial BKCa channel in adenosine receptor-mediated cardioprotection has not been investigated. GPCR …
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A study of the WKY as a rat model of depression
… experiments. Desipramine had no effect on opioid receptors (μ - and κ - opioid receptors, MOR and KOR, respectively) , and tyrosine hydroxylase in the nucleus accumbens ( NAc ) or prefrontal cortex ( PFC ) of WKY rats.
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Diverse Kappa Opioid Receptor Agonists: Relationships Between Signaling and Behavior
<p>The opioid system, comprised mainly of the three opioid receptors (kappa, mu and delta) and their endogenous neuropeptide ligands (dynorphin, endorphin and enkephalin, respectively), mediates mood and reward. Activation of the mu opioid receptor is associated with positive reward and euphoria, …
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Secondary Metabolites from Otanthus maritimus, Stachys glutinosa and Withania somnifera: Isolation, Structure Elucidation and Interactions with Cannabinoid and Opioid Systems
… secondary metabolites that bind to CB and/or opioid receptors, we selected four extracts that showed interesting affinity versus the above mentioned receptors . In particular: the DCM extract obtained from the aerial parts of Stachys glutinosa (SGE) was able to bind with a good affinity both …
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Opioid regulation of ingestive behavior in the domestic fowl
… were conducted to examine the role of endogenous opioid peptides in the regulation of ingestive behavior in the domestic fowl. In the first study, the dose-response relationships of two opioid antagonists, naloxone and naltrexone, were evaluated in Rock-Comish (RC) and Single-Comb White Leghorn …
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The Effects of Nucleus Accumbens Opiate and Adenosine Receptor Activity on Appetitive Operant Learning
… reward processes. Systemic manipulations of the opioid and adenosine receptor pathways influence learning in several different paradigms. Manipulations of both of these receptors within the nucleus accumbens affect motivational aspects of instrumental conditioning and food intake. The nucleus …
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