Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Opioid agonist"”.
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Enhancing the use of opioids in pain management: antinociceptive potentiation with opioid agonist/antagonist combinations.
While opioids are the most effective and widely used class of drug for the management of moderate to severe pain, their use may be limited by adverse effects that are unpleasant and potentially dangerous. Research is increasingly directed towards strategies to improve the use of opioids in pain …
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Personality and attention bias in adults with a history of childhood trauma, and attenuating effects of mu-opioid agonist buprenorphine on attention bias
… also examined the possible effects of the mu-opioid agonist buprenorphine on attentional bias in the Trauma group.
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Induction of transdermal buprenorphine (Butrans®) to extended-release buprenorphine subcutaneous injection (Sublocade®) for opioid use disorder: a case series & a qualitative study on the experiences, barriers, and understanding of opioid agonist treatment among youth with opioid use disorder in Vancouver, British Columbia
The opioid crisis is a profound public health crisis, with devastating impacts on individuals, families, and communities in North America. Vancouver is one of the most affected regions in Canada. To combat the rising opioid overdose epidemic, opioid agonist treatment and harm reduction services …
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The effects of the kappa agonist U-50,488 on morphine-induced place preference conditioning and Fos immunoreactivity in the preweanling and periadolescent rat
The effects of the kappa opioid agonist U-50,488 on morphine-induced condtioned place preference (CPP), locomotor activity and Fos immunoreactivity and assessed in 10-, 17- and 35-day old rats. It was predicted that kappa agonist treatment would block the unconditioned and conditioned behaviors …
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Synthetic Work Towards Salvinorin A
… known as salvia. It is a highly selective kappa opioid agonist, which gives it potent hallucinogenic and potent analgesic properties. The natural compound was isolated and characterized in 1982, and a multitude of pharmacological and derivatization studies have been performed to highlight its …
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Intra-nacc adenosine and its role in mediating palatable food intake: interactions with striatal opioids
… alone and when co-administered with the [mu]-opioid agonist DAMGO or the opiate antagonist naltrexone. The influence of the A1 receptor agonist CCPA, the A1 receptor antagonist DPX, the A2A receptor agonist CGS 21680, and the A2A receptor antagonist MSX-3 on feeding behaviors was investigated. …
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The Role of Substance P in Opioid Induced Reward
… affects approximately 100 million Americans. Opioids are the mainstay therapy for the treatment of chronic pain. While physicians and patients alike are apprehensive about using opioids due to their side effects including respiratory depression and addiction, 259 million opioid prescriptions …
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Informing the treatment and prevention response for HIV among people who inject drugs: a case study of South Africa
… increased 7-fold over 2002-2017, including in opioid use and is associated with higher sexual risk behaviours and some health outcomes. Secondly, I undertook the first ever global systematic review and meta-analysis to quantify HIV viral suppression among PWID and compare outcomes with other …
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Characterizing Effects of Sphingosine-1-Phosphate Receptor 1 Activation in Subtypes of Central Amygdala Neurons and Effects of Prenatal Methadone Exposure on Motor Cortex Neurons in Mice
… allowed me to study the effects of S1PR1 agonist SEW2871 and S1PR1 antagonist NIBR on the cellular physiology of CeL Sst neurons. My findings reveal intrinsically distinct subtypes of CeL Sst neurons that are uniquely affected by S1PR1 activation, which may have implications for how S1P …
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Human subjective homologues of established basic emotion correlations in lower mammals: a neuro-psychoanalytic study
… volunteers (N=16) via the administration of opioid and dopamine antagonists and agonists. This was an exploratory study, with a double-blind, placebo-controlled, repeated-measures design. The effects of the medications on SEEKING, PANIC/GRIEF, positive and negative affect and mood were …
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Pharmakologisch unterstützte manuelle Spermagewinnung und computergestützte Spermienkopfmorphometrie beim Breitmaulnashorn (Ceratotherium simum)
… was performed. A combination of the alpha-2-agonist Detomidine-Hydrochloride (Domosedan) and the partial opioid agonist Butorphanol (Butomidor) was administered intramuscular. In order to provide adequate safety margins for the operating persons, important requirements consist in a restraint …
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Regulation and site of action of exogenous and endogenous opioids on growth hormone and prolactin secretion in Holstein calves
… and site of action of exogenous and endogenous opioids on pituitary growth hormone (GH) and prolactin (PRL) secretion in Holstein calves. In the first study, the effect of the opioid agonist DAMME (D-Ala²⁺,N-Me-Phe⁴,Met(O)⁵-01 enkephalin) on plasma GH and PRL secretion was measured in Holstein …
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Exploration of Platelet and Mast Cell Communication: A Study of Membrane Lipids, Asthma, and Inflammation
… factors such as lipid membrane concentration, opioid agonist exposure, and inflammatory diseases impact cell communication. It explores the use of different cell models, specifically platelets and mast cells, to understand how disease states can impact cellular function. Throughout the thesis, …