Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"Opioid abuse"”.
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Metabolism And Pharmacokinetics In The Development Of New Therapeutics For Cocaine And Opioid Abuse
Cocaine and opioid abuse are a major public health concern and the cause of significant morbidity and mortality worldwide. The development of effective medication for cocaine and opioid abuse is necessary to reduce the impact of this issue upon the individual and society. The pharmacologic …
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Three studies on managers' disclosure decisions
My first study examines whether and how opioid crisis affects management forecast quality. Lax regulations and the spreading of misinformation by pharmaceutical companies have resulted in a massive increase in opioid prescriptions in the United States, with the abuse of these drugs reaching crisis …
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Three studies on managers' disclosure decisions
My first study examines whether and how opioid crisis affects management forecast quality. Lax regulations and the spreading of misinformation by pharmaceutical companies have resulted in a massive increase in opioid prescriptions in the United States, with the abuse of these drugs reaching crisis …
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Predictors Of Dental Opioid Analgesic Prescribing, Opioid Use And Dental Emergency Department Visits In The Mississippi Medicaid Population
… this study were: (1) to determine prevalence of opioid analgesics prescribing for non-ED dental related visits in the Mississippi Medicaid population, (2) to assess predictors of receiving opioid analgesics following non-ED dental related events among Mississippi Medicaid beneficiaries, and (3) …
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Counseling interventions with buprenorphine for treatment of opioid use disorders
Opioid abuse and opioid related deaths continue to affect families and communities across the United States. Medication-assisted treatment shows advantages over other types of interventions for opioid use disorder (OUD) (Bart, 2012). While buprenorphine, an approved medication for the treatment of …
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Euphoria: The Transition from Prescription Opioids to Heroin in Kentucky
… demand for and availability of prescription opioids has been quite prevalent in the state of Kentucky primarily since the early 1990's. But between 2010 and 2012, reformulations of opioids OxyContin and Opana, along with the passing of HB 217 and mandatory KASPER (Kentucky All Schedule …
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Needles in a Haystack: Perceptions of Deservingness on the Implementation of Harm Reduction Programs in the American Midwest
The association of opioid abuse with rural, white, working-class individuals ultimately generated sympathy, rather than hatred, in the general political zeitgeist. However, some cases deviated from this pattern by adhering to the common cycle and villainizing individuals with substance use disorder …
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National Study of Discontinuation of Long-Term Opioid Therapy Among Veterans
… have high rates of chronic pain and long-term opioid therapy (LTOT). Understanding predictors of discontinuation from LTOT will clarify the risks for opioid abuse and dependence among veterans, and inform Veterans Healthcare Administration (VHA) policy. Methods: All veterans with at least 90 …
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Nursing Students’ Knowledge and Attitudes About Pain Management and Opioids
… healthcare professionals’ knowledge of using opioids for pain management safely is critical in preventing opioid abuse and overdose. Undergraduate curricula of health professional schools, including undergraduate nursing programs, need to improve and adopt a comprehensive education regarding …
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Emotional risk factors for substance abuse in a chronic pain population: Developing a predictive model and testing methods for assessing stigmatized behaviors
… predictive factors applied to prescription opioid abuse in chronic pain patients is surprising given the breadth of personal, cognitive, and emotional factors explored in both chronic pain and substance abuse literatures broadly. The present study had two purposes. First, concurrent risk …
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OPIOID ADDICTION AND PREGNANCY: POTENTIAL EFFECTS OF SUBSTITUTION THERAPIES ON DEVELOPMENTAL MYELINATION
… of the central nervous system (CNS) express opioid receptors, the role of the endogenous opioid system in CNS development remains poorly understood. Identification of opioid functions during brain maturation is particularly crucial in light of the increasing trend in opioid abuse and the use …
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Benzodiazepine and opioid dependence. Clinical and meta-analytical studies.
… 1/5 of the BZD dependent and 1/3 of the opioid dependent patients reported high tolerance, DDD > 4.0 of each drug. Common for the third and forth paper was the meta-analytical technique. In the methadone paper 8 RCT were included with 1,511 patients. In the naltrexone study 15 RCT were …
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The Effects of Dopamine D3 Receptor Compounds on Oxycodone Self-Administration and Reinstatement in Female Cynomolgus Monkeys
… novel pharmacotherapies for the treatment of opioid use disorder (OUD) is essential. In the United States, there currently exists an opioid crisis as a result of the high prevalence of people abusing opioids and staggering number of overdose deaths. Animal models have been used extensively to …
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Safe injections sites as a solution to the opioid crisis : a policy analysis
Over the past 20 years, the fatality rate from opioid and drug overdoses has dramatically increased in the United States. Clearly, a solution is needed to address this vast and serious problem. While Michigan Governor Gretchen Whitmer recently enacted legislation investing over $800 million towards …
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Reducing opioid overdose-related deaths in Michigan : a policy analysis
Currently, the opioid epidemic is spreading across the United States (U.S.) leaving individuals, families, and communities fractured. According to the Centers for Disease Control and Prevention (CDC) (2020) opioid overdose is the leading cause of mortality and disability among people with opioid …
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Essays on the economics of population health
… is often portrayed as one of the drivers of the opioid epidemic. Better employment conditions can, however, affect opioid use through two channels: increasing physical pain from working or reducing mental distress that can contribute to substance abuse. I use a large dataset of opioid and …
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Characterisation of the role of peripheral μ-opioid receptors in the behavioural effects of heroin and their underlying neural systems in the rat
The behavioural effects of opioids such as heroin have long been considered to be mediated by central mechanisms. However in recreational use, opioids are administered systemically and can therefore influence peripheral μ-opioid receptor-dependent systems before they reach the brain. In humans, …
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Identification and treatment of opioid use disorder in the emergency department
Background: Opioid Use Disorder (OUD) is a common comorbidity in emergency department (ED) settings. This study aimed to introduce a standard of care that incorporates medication-assisted treatment and facilitates referrals for continuous therapy among individuals with OUD seeking assistance in the …
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Withdrawal from Voluntary Oral Methamphetamine Reveals Female Specific Susceptibilities to Behavioral Deficits and Neurochemical Perpetuators of Neurotoxicity and Drug Seeking Behavior
… mitigate the detrimental effects associated with opioid abuse<sup>17</sup>. This highlights the need for the development of a translationally sensitive rodent model of MA addiction to better model human MA use and identify therapeutic intervention for susceptible populations including females. …
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Predictors of the Risk for Aberrant Drug-Related Behavior in Chronic Pain Patients: A Mixed Methods Design
<p>The use of opioids for the treatment of chronic non-cancer pain (CNCP) remains controversial (Manchikanti, 2008; McQuay, 1999). Controversy surrounds the type of conditions that should be treated with opioids, whether the treatment can be generally safe and effective, and what the clinical goals …
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