Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Oocyte-to-embryo Transition"”.
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Context Dependent Regulation of Dicer Function During Oocyte-to-Embryo Transition
… germ cell functions remain poorly defined. Work to parse these mechanisms in C. elegans, where small RNA function was first identified, has amplified our overall understanding of endo-siRNA function, including the revelation that the Dicer helicase domain has an exclusive regulatory effect on …
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The oocyte-to-embryo transition : regulation of oocyte maturation and egg activation in Drosophila
In oogenesis, meiosis must be highly regulated to ensure that growth of the oocyte and chromosomal segregation are coordinated properly. To do this, meiosis arrests at two points to permit oocyte differentiation and coordination with fertilization. In Drosophila, the first arrest in prophase I is …
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A meiosis-specific form of the Anaphase Promoting Complex/Cyclosome regulates the oocyte-to-embryo transition in Drosophila
Cell cycle transitions during mitosis and meiosis must proceed in an irreversible manner. At the heart of this is the Anaphase Promoting Complex/Cyclosome (APC/C), an E3 ubiquitin ligase. The APC/C targets its substrates for degradation, and thus progresses the cell cycle irreversibly forward. Many …
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Investigating processing body condensation, material properties and function during early Drosophila development
… Cellular material can be organised into membrane-bound or membrane-less compartments. The latter, commonly known as biomolecular condensates, often contain ribonucleoprotein assemblies that form via liquid-liquid phase separation. Conserved across eukaryotes, Processing bodies (P …
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C. Elegans OMA-1 and OMA-2 are Transcriptional and Translational Repressors of Germline Fate
… of genetic material through many generations, to ensure flawless perpetuation of the species and life cycles. The germline lineage is set aside as early as embryogenesis and kept quiescent until germ cells are needed for adult reproduction. During C. elegans germline development global …
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Investigating the role of egg-3 by characterizing the egg-3(as40) phenotype in C. elegans
Egg activation is a process whereby a mature oocyte transitions from meiosis to mitosis and changes to a new cellular state that supports embryogenesis. In C. elegans, egg activation is regulated by a complex of proteins which include EGG-3, EGG-4, EGG-5, CHS-1 and MBK-2. EGG-3 is a member of the …
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Investigating the function and mechanistic control of processing bodies in early Drosophila melanogaster development
… are physically segregated from the rest of the cytoplasm or nucleoplasm, despite the lack of a limiting membrane. This results in a specialised intracellular region that likely carries out a specific cellular process. A particularly well-studied class of biomolecular condensates that contain both …
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Dynamic relocalization of maternal transcripts during oocyte meiotic maturation
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-12-01