Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"One-carbon Metabolism"”.
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A study of the phylogenetics, nutrition and one-carbon metabolism of Syntrophococcus sucromutans
Syntrophococcus sucromutans is phylogenetically included in the Gram-positive phylum of the Eubacteria, by virtues of 16S ribosomal RNA sequence similarity analysis. It is part of a well defined genealogic entity described as the Butyrivibrio subdivision which, like the Sporomusa subdivision …
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The relationship of folic acid compounds to one-carbon metabolism in the tabacco plant
Thesis (M.S.)--Michigan State University of Agriculture and Applied Science. Dept. of Chemistry, 1958
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Maternal rumen-protected methionine supplementation alters dairy calf development, postnatal growth, plasma biomarkers, and liver one-carbon metabolism
… During this critical time maternal nutrition is one of the most important factors that can affect offspring health and performance. Methionine, besides being the first limiting amino, is an important precursor of antioxidants and methyl donor. Therefore, our objectives were to investigate if …
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Design and Synthesis of Pyrimidine Based Heterocycles as Potential Anti-cancer Agents with Combination Chemotherapeutic Potential or Targeted One Carbon Metabolism Inhibition and Anti-opportunistic Agents
… effects and cytotoxic effects or b) one-carbon metabolism inhibitors for targeted tumor therapy; or c) selective <em>Pneumocystis jirovecii </em>(pj)<em> </em>dihydrofolate reductase (pjDHFR) inhibitors for pneumocystis pneumonia (PCP) infection.</p> <p>The work in this dissertation …
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MOLECULAR DRIVERS OF DISEASE PATHOGENESIS IN NONALCOHOLIC STEATOHEPATITIS
… fatty liver disease (NAFLD) is the number one cause of chronic liver disease worldwide, with 25% of these patients developing nonalcoholic steatohepatitis (NASH). NASH is characterized by steatosis, inflammation, cell death, and liver fibrosis and significantly increases the risk of …
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The Impact Of Folate Restriction On Cancer And Aging: A Mechanistic Analysis
… interventions extend lifespan by altering the one carbon metabolism. In this study, we present folate restriction as a possible nutritional intervention to extend lifespan and improve health span impacting one carbon metabolism and the mTOR signaling pathway.</p>
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Modeling the interactions between the circadian clock, dopamine, and metabolism
… (3) Mathematical modeling of sex differences in one-carbon metabolism. Circadian rhythms, dopamine, and metabolism are all important aspects of human physiology and we use methods from dynamical systems and scientific computing to investigate these systems at the molecular level. </p><p>First, we …
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Trim24 Promotes Mammary Tumor Development By Upregulating Metabolic Reducing Power
… hallmark of cancer cells. Changes in cellular metabolism can contribute to cancer cell survival and tumor progression. Tripartite motif-containing protein 24 (TRIM24) is an E3 ligase for p53, a nuclear receptor co-regulator, and a histone reader. Over expression of TRIM24 correlates with poor …
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Methodologies and analysis of metabolic flux in mammalian systems
… physiology. Isotope tracing with heavy labeled carbon (13C labeled metabolic flux analysis, 13C-MFA) is a promising strategy due to its ability to compute metabolic fluxes from isotope tracing profiles without relying on assumptions such as metabolic objectives or enzyme kinetic parameters. …
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Molecular and biochemical analyses of the role of nutrition and body condition in Holstein cows and the developing fetus
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-12-01
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Management during the dry period and its effect on hepatic and adipose tissue molecular biomarkers of metabolism and health in grazing dairy cows
… and adipose tissue transcriptome, and the liver one-carbon metabolism and transulfuration pathway. Cows were randomly allocated to one of four groups in a 2 × 2 factorial arrangement: 4.0 or 5.0 BCS prepartum (10-point scale) and dietary energy at 75 or 125% of estimated requirements during the …
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The Role of Metabolism and Epigenetics in Regulating Cellular Plasticity
… are read, written, and erased on DNA and on histone protein, which package our DNA. The writing and erasing of epigenetic marks requires metabolic products including but not limited to, acetyl-CoA, methionine, and NAD+. Consequently, cell metabolism, epigenetic regulation, and cell phenotype are …
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Longitudinal Metabolic and Proteomic Changes Studied in an Experimental Model of Traumatic Brain Injury
… oxidation, perturbations to glucose and one carbon metabolism, energy failure, impairment of antioxidant capacity, blood-brain barrier BBB breach and elevated glial acidic fibirillary protein (GFAP). GFAP levels remain elevated in the cortex and hippocampus at 3 months and return close to …
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Interaction between retinoids and methyl group metabolism
<p>Methyl group and folate-dependent one-carbon metabolism play in integral role in health and disease. The donation of carbon in the production of nucleic acids from folate coenzymes and the methylation of biological compounds via transmethylation metabolism is important for maintenance of cells …
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Biochemical and physiological exploration of the nutrient sensing pathway upstream of mTORC1
… state, which is regulated by several multi-component complexes. Leucine and arginine are known activators of mTORC1 with reported corresponding sensors. Despite years of research, two essential questions still remain: 1. What and how other inputs impact mTORC1 activity? 2. What are the …
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Immunometabolism of methyl donors by dairy cattle during periods of negative nutrient balance and heat stress
… decreased milk production and altered immunometabolism. The first experiment examined the effects of post-ruminal choline supply during NNB on production and pathways of one-carbon metabolism. Ten primiparous rumen-cannulated cows (158 ± 24 DIM) were used in a replicated 5 5 Latin square …
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Gastrointestinal function in cattle: Mechanisms and the role of nutrition
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-12-01
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Single Nucleotide Polymorphisms in the Folypoly-gamma-glutamate synthetase Gene
… acid is an essential vitamin utilized in the one-carbon metabolism pathway for the synthesis of purine and thymidine nucleotides, which are necessary for cell growth and proliferation. As a result, the enzymes that participate in the metabolism of folic acid have been good targets for cancer …
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The Interaction of Obesity and Age and their effect on Adipose Tissue Metabolism in the Mouse
Numerous studies have investigated how bulk lipid metabolism is influenced in obesity and in particular how the composition of triglycerides found in the cytosol change with increased adipocyte expansion. However, in part reflecting the analytical challenge the composition of cell membranes, and in …
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