Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 50 for “"Oncoproteins"”.
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E1B and E4 adenoviral oncoproteins modulate cellular responses to DNA damage
A productive adenovirus infection inundates the host cell with linear, double-stranded DNA molecules and an abundance of single-stranded DNA. The cellular responses of cell death and cell cycle arrest to this apparent profusion of damaged DNA are antagonized by overlapping activities encoded in the …
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Overcoming Tumor Drug Resistance By Activating Amp-Activated Protein Kinase And Destabilizing Oncoproteins
<p>Although considerable progress has been achieved in the field of cancer therapeutics, primary or acquired drug resistance remains a fundamental cause of therapeutic failure in cancer therapy. Among different mechanisms characterized that are responsible for tumor drug resistance, there is …
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The role of human papillomavirus type 16 E6 and E7 oncoproteins in angiogenesis
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Analysis of senescence-like growth arrest induced by RUNX1 and its fusion derived oncoproteins
… by RUNX1 and its fusion derived leukaemogenic oncoproteins in primary fibroblasts. My work showed that RUNX1 induces a strong senescence-like response in murine and human primary fibroblasts that requires intact DNA binding, CBFB interaction and C-terminal transcriptional activation/repression …
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NEUROFIBROMATOSIS TYPE 2 PROTEIN (NF2) AS A REGULATOR OF TUMOR SUPPRESSORS AND VIRAL ONCOPROTEINS IN HUMAN GLIOBLASTOMA
… molecular interplay among tumor suppressors and oncoproteins can greatly contribute to the development of novel therapeutics that will extend life expectancies. The most common abnormality in these tumors is mutation of the p53 gene (TP53). Due to the expansive network of p53-responsive genes, …
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The Effects Of Curcumin On The Expression Of P53 And Bcl-2 Oncoproteins On The Human Breast Carcinoma Cell Line MDA-MB 468
… difference in expressions of both p53 and Bcl-2 oncoproteins across the four treatments. Future studies will investigate additional mechanisms by which curcumin induces these apoptotic effects.</p>
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Targeting the Central Dogma to Inhibit Nodes of Convergence in Cancer
Cancer treatments often target singular oncoproteins in attempt to block one hallmark of cancer and stop tumor growth and progression. However, although these treatments are often initially effective, many cancer patients develop resistance and experience relapse due to redundant signaling or tumor …
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Mechanism of Human Papillomavirus E6-Mediated Repression of P53-Target Gene *Transcription
… of p53. Using both high-risk and low-risk HPV E6 oncoproteins, each representing a class of oncoproteins that is capable of inducing p53 degradation or unable to degrade p53, respectively, we investigated whether these DNA tumor viruses shared a general repression mechanism to inhibit p53-target …
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Ehrlichia chaffeensis E3 Ligase TRP120 Ubiquitinates Tumor Suppressor FBW7 for Degradation to Promote Infection
… (SCF) known to negatively regulate a network of oncoproteins (Notch, cyclin E, c-Jun, MCL1 and cMYC). In this study, we demonstrate that TRP120 and FBW7 colocalize strongly in the nucleus by confocal immunofluorescent microscopy and interactions between TRP120 and FBW7 FBOX and WD40 domains were …
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Regulation of RNA polymerase III transcription by the ID1, ID2, ID3 and E47 proteins
… Furthermore, it has been shown that a number of oncoproteins and tumour suppressor proteins interact directly with the pol III machinery. The work presented in this thesis aimed to investigate whether the inhibitor of differentiation (ID) and E47 proteins regulate pol III transcription, as well …
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Epigenetic repression of the NFATc1 transcription factor in human lymphomas
… mammalian genes whose products can act both as oncoproteins and tumor suppressor genes (Hibi et al., 2000; Stiewe and Putzer, 2002), and it is likely that more genes exist which encode both tumor suppressors and oncoproteins. It remains to be shown whether the nfatc1 gene is one of them.
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Investigating the Role of ZNF384 Rearrangements in Acute Leukemia
… fusions. While expression of ZNF384 fusion oncoproteins in either mouse or human hematopoietic progenitors resulted in hematopoietic expansion, lineage skewing, and for some fusion partners, self-renewal in vitro; co-expression with common concomitant lesions, such as NRAS G12D, was …
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Functional characterisation of the N-terminal domain of polyomavirus large T antigen
… researched the relationship between viral oncoproteins and cellular tumour suppressor proteins in recent years, the molecular interactions between these proteins is still poorly understood. It is the goal of this thesis to establish the key elements of specific interactions, in particular …
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The Role of Glucocorticoid Signaling in Prostate Cancer Health Disparities
… of GR activation on the expression of stress oncoproteins linked to tumor aggressiveness and therapy-resistance, specifically Lens Epithelium-Derived Growth Factor p75 (LEDGF/p75) and Clusterin (CLU). Results revealed a robust pattern of GR-induced upregulation of LEDGF/p75 and CLU in …
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Inhibition of the transcription factor AP-1 in cervical cancer
… a key role in the regulation of the E6 and E7 oncoproteins of high-risk Human Papillomaviruses (HPV) that are etiologically associated with cervical cancer. The c-Jun and Jun B components of AP-I were shown to be expressed at higher levels in cervical cancer patients compared to nonnal patient …
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Regulation of the Arf tumor suppressor by E2F transcription factors
… to oncogenic stress, such as expression of the oncoproteins c-Myc or adenovirus E1A, or loss of the tumor suppressors Rb or p53, activating E2F proteins are recruited to Arf and transcription of the gene is induced. In normal mouse tissues Arf is not expressed, yet E2F does not participate in …
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RET receptor activation targets expression of the pleiotropic cytokine interleukin-11
… thyroid carcinoma (MTC), whereas RET fusion oncoproteins generated by gene rearrangements are associated with papillary thyroid carcinoma (PTC). In gene expression screens, interleukin-11 was identified as a RET-responsive gene. We sought to characterize the expression of IL-11 in response to …
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Mechanism-Based Strategies to Enhance The Actions of A
… regulates the functional stability of client oncoproteins, such as STAT3, Raf-1 and Akt, which play a role in the survival of malignant cells. The chaperone function of HSP90 is driven by the binding and hydrolysis of ATP. The geldanamycin analog, 17-AAG, binds to the ATP pocket of HSP90 …
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Understanding the Role of Delta-catenin in Virus-Positive Merkel Cell Carcinoma
… and the persistent expression of its viral oncoproteins, small tumor (ST) antigen and truncated large tumor (t-LT) antigen. However, the MCC cell of origin remains unknown. Identifying the cell of origin could provide critical insights into MCC pathogenesis and lead to more effective …
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