Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Oncometabolite"”.
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A Cell-Based Model to Study Factors that Drive Diffuse Astrocytoma Development
… mutations, which catalyze isocitrate to the oncometabolite D-2-hydroxyglutarate (2-HG) instead of alpha-ketoglutarate (α-KG). As 2-HG accumulates, it induces a hypermethylator phenotype that prevents the cells from differentiating. Acquisition of additional mutations in tumor suppressors such …
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Förster Resonance Energy Transfer-Based Quantification of D-2-Hydroxyglutarate & Locked Nucleic Acid Loop-Mediated Isothermal Amplification Mediated Detection of IDH1-R132 Single Nucleotide Variants in Glioma
… quantifies D-2-Hydroxyglutarate (D-2-HG), an oncometabolite and surrogate marker of <em>IDH1</em> mutations, while the genotyping panel identifies the specific <em>IDH1</em>-R132 single nucleotide variant (SNV) present. The biosensor’s robust function in biological fluids suggests its powerful …
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<i>PTHR1/SOX9</i> and <i>IDH1/IDH2</i> Relative Expression in Primary Chondrocyte and Chondrosarcoma Cells Under the Synergistic Influence of Inducible Hypoxia and Extracellular Acidosis
… further convert α-KG into a competitive oncometabolite D-2-Hydroxygluterate (D-2-HG). Our colorimetric assay data suggest that D-2-HG concentration levels are 10.5-fold and 6-fold more elevated in JJ012/SW1353 respectively than in the <em>IDH</em> wild type CON5. Our gene expression data …
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CROSSTALK BETWEEN GLIOMA CELLS AND TUMOR ASSOCIATED-MACROPHAGES: MECHANISMS AND THERAPEUTIC STRATEGIES
… metabolic features, such as accumulation of the oncometabolite 2-hydroxyglutarate, are associated with IDH-mutations. Despite many therapeutic strategies, GBM recur in almost all patients and prognosis remain poor, the development of new therapeutic strategies is strongly needed. In the last …
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A novel GC-MS/MS assay for the measurement of 2-hg enantiomers and the utility of 2-hg enantiomer levels as a biomarker for IDH mutant gliomas
… brain tumor. Mutant IDH (IDHmut) produces the oncometabolite, (R)-2-hydroxyglutarate (R-2-hg), resulting in a significant increase of intracellular concentrations above physiological levels. However, a lack of correlation between circulating 2-hg levels and IDH status has been observed. This is …
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Preclinical Studies of A Novel Idh1 Inhibitor In Acute Myeloid Leukemia (Aml)
… of mutant IDH1 results in accumulation of the oncometabolite 2-hydroxyglutarate (2-HG), leading to a hyper-methylation phenotype, a block in cell differentiation, and tumor growth. Inhibitors of IDH1 mutant enzyme reduce 2-HG levels and release the differentiation block allowing AML cells to …
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Mechanisms driving the expansion and progression of splicing factor-mutant clonal haematopoiesis
… intermediates such as 2-oxoglutarate and the oncometabolite 2-hydroxyglutarate (2HG), which has previously been linked to leukaemogenesis following acquisition of IDH1/2 mutations. We also observed an enhanced sensitivity to glycolysis inhibition in SF3B1-mutant cells, representing a potential …
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Computational modeling of tumor cell growth as a function of nutrient dynamics guided by time-resolved microscopy
The varying and extreme nutrient conditions found in the tumor microenvironment force reprogramming of metabolism in tumor cells. This metabolic reprogramming has been identified as a hallmark of cancer. This dissertation focuses on the development and validation of an experimental-mathematical …