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Showing 1 to 13 of 13 for “"Oncolytic virotherapy"”.
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Enhancing Oncolytic Virotherapy Using Functional Genomic Screening
The treatment of cancer patients with oncolytic vaccinia virotherapy has yielded encouraging results in early phase clinical trials, but there are yet unexplored opportunities for improving this therapy that could lead to even better outcomes for patients. To this end, we harnessed the power of …
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Improving the effectiveness of oncolytic virotherapy: insights from mathematical modelling
Oncolytic viruses are viral particles that specifically infect cancer cells, while mostly preserving healthy tissues. Their use as cancer treatment has received considerable attention in recent years, but their clinical use still faces many challenges. Some of the main obstacles to the propagation …
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Targeted Oncolytic Virotherapy Using Newcastle Disease Virus Against Prostate Cancer
… CaP including stem cells are imperative. Oncolytic virus (OV) therapy is a novel approach that overcomes the limitations posed by radiation and chemotherapy. Oncolytic virotherapy of cancer is based on the use of replication competent, tumor selective viruses with limited toxicity. …
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Engaging Immune Cells within the Tumor Microenvironment to Enhance Efficacy of Oncolytic Virotherapy
Oncolytic viruses are particularly attractive for many of the current cancer-immunotherapeutic modalities in their capacity to simultaneously cause direct lysis of tumor cells and indirect augmentation of host anti-tumor immunity. Despite widespread interest in the direct anti-cancer activity of …
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Evaluation of Adoptive T Cell Therapy and Oncolytic Virotherapy for Treatment of Brain Tumors
Item reinstated by Sarah Shreeves (sshreeve@illinois.edu) on 2013-01-22T11:00:26Z Item was in collections: University of Illinois Dissertations and Theses (ID: 204) Neuroscience Program Dissertations (ID: 630) No. of bitstreams: 3 Thomas_Diana.pdf.txt: 257425 bytes, checksum: …
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The Role of Anti-Viral Immune Response on the Therapeutic Efficacy of Oncolytic Virotherapy for High-Grade Gliomas
… and immune checkpoint blockade therapies. Oncolytic viruses offer a new treatment modality by selectively replicating in cancer cells and inducing anti-tumor immunity. Among these viruses, the oncolytic adenovirus Delta-24-RGD has shown safety and efficacy in clinical trials for high-grade …
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ARMING STRATEGIES TO IMPROVE THE IMMUNOTHERAPEUTIC POTENTIAL OF ONCOLYTIC HERPESVIRUSES
Exploiting the capacity of oncolytic viruses (OVs) to selectively target and destroy tumor cells while triggering robust antitumor immune responses offers a highly promising avenue in cancer immunotherapy. Inside the wide viral repertoire for oncolytic virotherapy, Herpes simplex virus type 1 …
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Oncolytic adenovirus vectors for nitroreductase suicide gene therapy of prostate cancer
… of Birmingham gene therapy group constructed two oncolytic adenovirus vectors, CRAd-NTR and vNR6, both of which contained the E1B-55K deletion and expressed the transgene nitroreductase for combined oncolytic virotherapy and enzyme/prodrug gene therapy. The latter of these two vectors, vNR6, …
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Virus-Based Nanoparticles for Tumor Selective Targeting and Oncolysis
Many oncolytic virotherapies have shown great advantages for rapid, rational design through recombinant DNA technology to facilitate the targeting of a broad spectrum of malignancies. Newcastle disease virus (NDV), an avian paramyxovirus, is naturally tumor-selective and inherently oncolytic. Our …
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Sterility and immunogenicity of gamma-irradiated respiratory viruses
… for NDV vaccine development. NDV is used as an oncolytic virus and many clinical trials have demonstrated the ability of NDV to treat a range of different cancers. However, research with NDV is hindered by the biosecurity risk associated with live NDV. Given the high structural integrity and …
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Increased Risk of Cutaneous Immune-Related Adverse Events in Patients Treated with Talimogene Laherparepvec and Immune Checkpoint Inhibitors: A Multi-Hospital Cohort Study
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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JAG1 Blockade With oHSV Polarizes Macrophages to Create a Unique Vulnerability for Cetuximab-Mediated Senolysis of Glioma Cells
<p>Oncolytic HSV-1 (oHSV) treatment induces Notch signaling and myelosuppression in the tumor microenvironment (TME) of preclinical models. In the clinic, upregulation of JAG1 gene expression was observed in recurrent high-grade glioma patients treated with CAN-3110. Since JAG1 is expressed on both …