Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 21 for “"Oncology Cancer"”.
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Vitamin D- induced down regulation of RAD51 in head and neck squamous cell carcinoma (HNSCC), In Vitro and In Vivo
… anti-proliferative effects in several mammalian cancer cell types. The molecular mechanisms of tumor suppression, however, are not clearly understood. Previous research has shown that head and neck squamous cell carcinoma (HNSCC) responds to VD<sub>3</sub>. This thesis used both in vivo and in …
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Experiences of patients regarding oncology treatment and care at hospitals in Vhembe District of Limpopo Province
See the attached abstract below
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Možnosti ergoterapeutické intervence u onkologicky nemocných
BAKALÁŘSKÉ PRÁCE Jméno: Dagmar Bejdlová Vedoucí práce: MUDr. Petra Sládková, Ph.D. Název bakalářské práce: Možnosti ergoterapeutické intervence u onkologicky nemocných Abstrakt: Cílem této bakalářské práce je přiblížit problematiku onkologicky nemocných a představit možnosti ergoterapeutické …
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Characterizing glucocorticoid receptor in metastatic castration resistant prostate cancer
… the context of enzalutamide resistant prostate cancer cells. Enzalutamide is a drug that functions to dampen androgen receptor (AR) signaling, thus inhibiting cancer dependency on the receptor protein. Although the application of the drug reduces AR signaling in these cancer cells, an alternate …
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Feasibility, acceptability and preliminary effectiveness of a video conference delivered, group-based physical activity program for cancer survivors
Background: Although supervised cancer rehabilitation and exercise programs are effective for improving health outcomes among cancer survivors, widespread access is lacking, and the COVID-19 pandemic highlighted the need for innovative ways to reach and serve cancer survivors in their homes. …
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Trends and Comparative Effectiveness in Treatment of Stage IV Colorectal Adenocarcinoma
… management of patients with stage IV colorectal cancer is evolving. Primary treatment modalities include systemic chemotherapy, resection of the primary tumor, and, in select cases, resection of metastatic disease. Historically, stage IV disease was first managed with surgical resection to …
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A prospective examination of change in executive function and physical activity in older breast cancer survivors
Only one third of older breast cancer survivors (BCS) meet national physical activity (PA) guidelines. Theories of self-regulation and research with older adults suggest that executive function (EF) plays an important role in PA, yet the impact of lower EF on older survivors’ PA is unknown. My …
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Mathematical approaches for the clinical translation of hyperpolarised 13C imaging in oncology
… shown to detect early treatment re- sponse in cancers and correlate with tumour grade. As the technique has recently been translated into humans, accurate and reliable quantitative methods are required in order to detect, analyse and compare regions of altered metabolism in patients. …
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Central arterial stiffness is associated with cognitive decline and cardiovascular disease manifestation in cancer survivors in the Framingham Heart Study
Introduction – Cancer survivors experience disproportionate prevalence of cognitive deficits and higher risk of CVD, due to a combination of shared biological mechanisms and anticancer treatment cardiotoxicity. Central artery stiffening, which increases following cancer diagnosis, inhibits …
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The Role of Stromal-Derived Factors in Neuroblastoma Differentiation
<p>Neuroblastoma is a pediatric cancer arising from undifferentiated neural crest-derived precursor cells. Treatment strategies for neuroblastoma aim to promote neuroblast differentiation, however current therapies available are only modestly effective. The tumor stroma contributes to the …
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The role of diet, nutritional assessment and nutritional intervention in the prevention of cancer and the treatment of cancer-related malnutrition
… role in both the prevention and the treatment of cancer. The aim of this thesis was to describe the prevalence of malnutrition in the Irish oncology setting using gold standard methods of body composition analysis and to explore the identification and treatment of cancer-related malnutrition, as …
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Functional and Therapeutic Relevance of MTAP Deletion in Glioblastoma
… it’s contribution to the formation of the cancer cell epigenomic landscape, stemness characteristics, growth, and response to therapeutic agents.</p>
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RELATIONSHIPS BETWEEN MASCULINITY BELIEFS AND COLORECTAL CANCER SCREENING IN MALE VETERANS
Colorectal cancer (CRC) is the third most common cancer diagnosed and the third most common cause of cancer deaths among men in the United States. Although CRC screening tests can reduce CRC incidence and mortality, men’s current rates of CRC screening fall below screening objectives. Results from …
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Molecular Analysis of Breast Cancer Transcriptomes, Genomes, and Circulating Tumor DNA
Breast cancer is a very heterogeneous disease in terms of clinical characteristics, genetic aberrations and prognosis. In Paper I, we focused on the CD44 molecule that often is aberrantly expressed in breast cancer and is widely used as a marker for cancer stem cells. Several isoforms of the CD44 …
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Impact of the gut microbiota on DNA methylation in colorectal cancer
… a distinct form of aberrant DNA methylation in cancer, and it is seen in 20-40% of colorectal cancers (CRC) where its causes remain elusive. Intestinal microbiota represents an important environmental component implicated in CRC development. Interestingly, microbiota have been shown to modulate …
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Analysing the relationship between immune infiltration and tissue architecture in high grade serous ovarian cancer
… that underlies them in high grade serous ovarian cancer (HGSOC). The quantitative distribution of three key immune infiltrates was initially assessed in the SEARCH cohort (n=332); CD8+ cytotoxic T-cells, CD45RO+ memory T-cells and CD68+ macrophages. The stromal infiltration of CD68+ (HR = 0.44, p …
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Therapeutic Effects and Targeted Delivery of Eupenifeldin in Castration-Resistant Prostate Cancer
Castration-resistant prostate cancer (CRPC) poses a major therapeutic challenge, as it often fails to respond to standard treatments such as taxane-based chemotherapies, androgen receptor pathway inhibitors, and radioligand-based approaches1–4. Despite these treatments, CRPC remains incurable, and …
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Register studies of cancer in the Southern Health Care Region in Sweden
… on a population based level for persons with cancer and their partners, and from an individual level to explore the impact of comorbidities in incidence and survival. In the beginning of the study all persons in the Southern Health Care Region in Sweden diagnosed with colon, rectal, breast, …
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Assessing the psychosocial impact of monoclonal gammopathy of undetermined significance (MGUS)
… multiple myeloma (MM), an incurable blood cancer. To date, limited research has focused on the psychosocial impact of receiving a MGUS diagnosis. This dissertation reports the findings from an exploratory-sequential mixed methods programme of work conducted to explore the lived experiences …
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