Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"Oncogenic Signaling"”.
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Oncogenic Signaling Pathways Activated by Lysophosphatidic Acid (LPA) in Ovarian Carcinoma
… cancer cells. To gain further insight into the oncogenic signaling response stimulated by LPA, activation of the mitogen activated protein kinase (MAPK) modules was determined. Using a series of immunoblot analyses and kinase assays, LPA was found to stimulate ERK as well as JNK modules. To …
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Targeting the Central Dogma to Inhibit Nodes of Convergence in Cancer
… and experience relapse due to redundant signaling or tumor heterogeneity. To avoid resistance mechanisms, cancer treatments must inhibit multiple hallmarks of cancer, and therefore multiple oncogenic signaling programs. One possible way to achieve this is to target nodes of convergence of …
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PROGRAMMED DEATH LIGAND 1 (PD-L1) IMMUNE CHECKPOINT-MEDIATED STIMULATION OF MALIGNANT PHENOTYPES IN TUMOUR CELLS
… checkpoint have focused on elucidating the signaling mechanisms leading to inactivation of immune effectors. We, along with others, have shown that signaling by the PD-1/PD-L1 immune checkpoint may be bidirectional. Hence, we hypothesized that PD-1/PD-L1 signaling promotes malignant …
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Synergistic inhibition of prostate tumor progression with a combination of curcumin and ursolic acid in the diet
… that the combination reduced activation of oncogenic signaling pathways, including STAT3, AKT, and mTORC1 compared to controls. The combination also modulated critical cell regulatory proteins consistent with inhibition of tumor cell proliferation. Analyses of microRNA expression in tumors …
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Dissecting mechanisms and consequences of oncogenic RTK fusion signaling
… broader implications of their activity for cell signaling and how these largely cytoplasmic proteins activate downstream pathways that originate at the plasma membrane. Here, we use optogenetics and live-cell imaging to find that EML4-ALK, an oncogenic fusion present in 5-7% of non-small cell …
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The RASSF1A Tumor Suppressor Regulates a Cascade of Oncogenic Signals That Are Restrained by G1 Checkpoint Mechanisms
… I found that RASSF1A depletion elevated oncogenic signaling pathways; however, RASSF1A depletion also induced cell cycle arrest. RASSF1A is a critical regulator in maintaining the balance between pro-growth and anti-growth signals. RASSF1A suppresses proliferative signaling pathways such …
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Il-6/Jak1 Drives Pd-L1 Phosphorylation and Glycosylation to Promote Cancer Immune Evasion
… and co-inhibitory molecules, regulates immune signaling activation, antigen presentation, and immune surveillance. Recent studies revealed that the glycan structures of co-inhibitory molecules are required for receptor-ligand interaction, a critical feature for activating cancer immune evasion. …
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Integrin-Mediated Mechanotransduction Controls Activation of Yap and Invasive Growth of Breast Cancer
… of breast cancer. Integrin-mediated adhesion and signaling are crucial for mammary tumorigenesis and tumor progression, in which focal adhesion kinase (FAK) - Src family kinases (SFKs) serves as a hub to relay the mechanical cues from the ECM. We have investigated the mechanisms through which …
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PHF6 modulates the chromatin landscape in B-cell leukemia
… up-regulation of genes involved in T-cell signaling, and give rise to mixed-lineage lymphoma in vivo. Engagement of divergent transcriptional programs results in phenotypic plasticity that leads to altered disease presentation in vivo, tolerance of aberrant oncogenic signaling, and …
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Evaluation of nanoscale delivery of miR 216 a/b, miR 217, and gemcitabine in pancreatic cancer cell lines
… epithelial-to-mesenchymal transition, and oncogenic signaling pathways were evaluated. While some expected trends were observed, such as increased BAX expression in apoptotic cell supernatants and elevated E-cadherin in treated cells, many protein expression changes did not align with the …
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TRPML1 Promotes Protein Homeostasis in Melanoma Cells by Negatively Regulating MAPK and mTORC1 Signaling
… to negatively regulate MAPK pathway and mTORC1 signaling. TRPML1-deficient melanoma cells exhibited decreased survival, proliferation, tumor growth, and macropinocytosis as well as serine depletion and proteotoxic stress. All of these phenotypes were partially or completely rescued by mTORC1 …
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Roles of Oxidative Stress and Dna Methylation In Cigarette Smoking-Induced Accelerated Acute Myeloid Leukemia Progression
… of myeloid progenitor cells, and activates oncogenic signaling in AML cells. My work highlights the potential for using smoking as a behavioral biomarker to help tailor treatment in AML patients.</p>
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Molecular Mechanisms of Metabolic Reprogramming in Pancreatic Cancer
… and several molecular determinants including oncogenic signaling pathways play pivotal roles in the development, progression and metastasis of pancreatic cancer. The aberrant glucose metabolism is the most prevalent key factor that influences pancreatic tumorigenesis. The cancer cells of …
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A Context-Forward In Vivo Functional Genomics Platform For Target Discovery and Establishing Vulnerability Context In Pancreatic Cancer
… to inform on more nuanced patterns of oncogenic dependency. We hypothesized that a more comprehensive and granular characterization of PDAC disease diversity is required to establish relevant context for targeted therapy. To this end, we sought to establish an integrated platform to: i) …
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A metabolic perturbation by U0126 identifies a role for glutamine in resveratrol-induced cell death
… LNCaP cells. Inhibiting downstream pro-survival signaling with the MEK inhibitor U0126 rescued the C4-2 cells from resveratrol-induced death, however other MEK inhibitors did not recapitulate this response. In fact, U0126 acted independently of MEK, inhibiting mitochondrial function and shifting …
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Quantitative analysis of signaling networks in proneural glioblastoma
… murine model of proneural GBM, we quantified signaling networks using mass spectrometry. We identified oncogenic signaling associated with the GBM model, such as increased phosphorylation of ERK1/2, P13K, and PDGFRA, relative to murine brain. Phosphorylation of CDK₁ Y₁₅, which causes G₂ /M …
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Dissecting Molecular Mechanisms of Radioresistance Using in Vitro and in Vivo Brain Tumor Model Systems
… analysis. Work has uncovered novel links between oncogenic signaling and DNA repair pathways. First, activation of the Akt pathway by EGFRvIII, a constitutively active form of EGFR, promotes DNA double strand break repair by non-homologous end joining in astrocytes and glioma cell lines. This …
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Development of a Neoepitope Prioritization Platform to Identify Immunogenic Neoantigens from Oncogenic FGFR3-TACC3 Fusion in Glioblastoma
… sequence that constitutively activates oncogenic signaling while remaining absent in normal tissues, thereby representing a highly specific therapeutic target. To evaluate its neoantigenic potential, 27 peptides (9-11 mers) spanning the fusion junction were assessed for HLA class I …
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Characterization of Novel Liver X Receptor Inverse Agonist in Breast Cancers
… inhibition by 1E5 can downregulate HER2-mediated oncogenic signaling and induce apoptosis. Taken together, these findings lay the foundation for the use of pharmacological LXR inhibition as a potential therapeutic strategy in targeting various aspects of breast cancers.
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