Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Oncogenic Mutations"”.
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A GNAQ/11-driven zebrafish cancer model identifies MITF and YAP as key determinants for uveal melanoma
… to cutaneous melanoma (CM), which is driven by oncogenic mutation of BRAF or NRAS, UM is driven by oncogenic mutations in GNAQ or GNA11 (>80% of patients). We developed a zebrafish model of UM by expressing GNAQ[superscript Q209L] in the melanocytes of p53-/- zebrafish. In this model, oncogenic …
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Whole body metabolic alterations as an early event in Kras-Driven cancers
… have gained critical insight into how different oncogenic mutations alter the regulation of metabolic pathways and shape nutrient utilization to facilitate the acquisition and synthesis of new biomass for daughter cells. These culture systems, however, rely on relatively homogenous cell …
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The origin and properties of pro-oncogenic fields in the intestinal epithelium
… Human colon cancer develops by acquisition of oncogenic mutations in the colonic epithelium throughout life. As secretory progenitors have unexpectedly been shown to be a significant source of colonic stem cells, they could serve a cell of origin for tumorigenesis. Furthermore, it has been …
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Function of the PDLIM2 protein in oncogenic Wnt signalling pathways
… theme in cancer biology. Hyper activation due to oncogenic mutations and paracrine activity has been found in both colon cancer and breast cancer, and continues to evolve as a central mechanism in oncogenesis. PDLIM2, a cytoskeletal PDZ protein, is an IGF-1 regulated gene that is highly expressed …
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Revealing the Mechanisms of Tumorigenesis Through Multi-Omics Analyses
… of tumorigenesis, extending from just hallmark oncogenic mutations to include large-scale genomic alterations, transcriptomic dysregulation, epigenetic reprogramming, and external influences such as environmental carcinogens and oncogenic pathogens. This heterogeneity, coupled with genomic …
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Predictive Reporter System for Investigating Dose Dependency in Oncogene-Induced Senescence
… mechanism which removes cells harbouring oncogenic mutations from the proliferation pool. However, senescent cells remain metabolically active and express factors of the senescence-associated secretory phenotype (SASP), which can conversely have a pro-tumorigenic impact on the cellular …
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The Origin of Genome Instability in Cancer: Role of the Fragile Site Gene Product FHIT
… multiple steps mediated by the acquisition of mutations, selection and clonal expansion of cells with favorable mutations. Most cancers exhibit remarkable genomic instability, defined as an elevated rate of genetic mutation at the single nucleotide and chromosome levels. Genomic instability is …
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RET Mediated Gene Expression and Cell-Migration
… cell-survival, differentiation, and migration. Mutations in RET can either interfere with or enhance normal RET signaling. Inhibiting RET mutations are associated with development of Hirschsprung disease, which is characterized by a lack of mature ganglia in the gut. Conversely, activating RET …
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KRAS Codon 12 and Codon 13 Mutations in Relation to Overall Survival among Colorectal Cancer Patients: A Systematic Review and Meta-Analysis
Oncogenic mutations in KRAS codon 12 and codon 13 within exon 2 are frequently occurring mutations in colorectal cancer (CRC). However, the existing published data on the association of KRAS codon 12 and codon 13 mutations on the survival of CRC patients remains inconclusive. To address this, we …
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Effects of Radiation Exposure on Lung Carcinogenesis
… responses change upon the acquisition of oncogenic mutations, the effects of fractionated or acute radiation exposure on lung carcinogenesis in vivo were determined utilizing the transgenic LA1 K-ras mouse model of lung cancer compared to wildtype littermates. Radiation-induced …
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Novel Oncogenic Drivers in Pediatric Gliomagenesis
… (DIPGs), harbored somatic heterozygous missense mutations in <em>ACVR1</em>, coding for a receptor serine-threonine kinase involved in bone morphogenetic protein (BMP) signaling. These alterations led to gain-of-function as evidenced by increased phosphorylation of downstream targets in primary …
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Modulation of Kras Structure and Dynamics By Kras Ubiquitination and Membrane Depolarization
… Dysregulation of KRAS signaling by oncogenic mutations leads to uncontrolled cell proliferation, a hallmark of cancer cells. Attempts to therapeutically target oncogenic KRAS have led to limited success resulting in a need to identify new mechanisms to targeting KRAS. The interaction …
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Biophysical Analysis of S100A12 and the Nucleosome Core Particle
… <p>The second part investigates how oncogenic mutations affect the physical stability and remodeling behavior of the nucleosome core particle. We focus on two cancer associated histone mutations: H2B E76K and H4 R92T. Using differential scanning calorimetry, thermal stability assays, …
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Evaluation of Altered Kras Codon Bias and NOS Inhibition During Lung Tumorigenesis
… rendering the proteins constitutively active and oncogenic. Lung cancer is the leading cause of cancer deaths worldwide, and more than 20% of human lung cancers harbor mutations in <italic>RAS, with 98% of those occurring in the <italic>KRAS isoform. While there have been many advances in the …
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Role of Phosphorylated Dicer1 In Tumor Progression
… when combined with heterozygous <em>Kras</em> oncogenic background contributes to lung tumor progression <em>in vivo</em>. Mechanisms through which phosphomimetic <em>Dicer1</em> regulates tumor progression remain undefined.</p> <p>In this thesis, I discovered that phosphorylation of DICER1 …
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Oncogenic Kras and Telomere Biology In Crc Progression
… to advanced CRC. </p> <p>Human CRCs carrying oncogenic mutations in the <em>KRAS</em> oncogene, henceforth referred to as KRAS*, exhibit a 25% higher propensity for developing liver metastases. Similarly, in our CRC mouse model, engineered with an inducible <em>Kras</em>* transgene and …
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Oncogene-induced reprogramming of heterotypic cellular interactions
… proliferation and differentiation. Activating mutations in KRAS are among the most frequently occurring oncogenic mutations driving cancers that are particularly refractory to therapy (e.g., colorectal, pancreatic, and lung cancer). KRAS mutations not only perturb intracellular signalling …
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Deciphering Cancer Metabolic Dependencies in the Tumor Microenvironment
… these restrictions, cancer cells often possess oncogenic mutations or amplifications to divide rapidly but can also rewire their metabolism in adaptation to the environmental challenge. The metabolism of cancer cells exhibit high plasticity as many metabolic pathways and enzymes are redundant. …
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NOVEL PEPTOID TARGETING CELL SURFACE VIMENTIN FOR LUNG CANCER TREATMENT
… malignancy via the stepwise introduction of key oncogenic mutations such as alternations of p53, KRAS, and cMyc. We hypothesized that novel cancer-specific cell surface markers may appear due to these oncogenic alternations, and then those can be captured by bead-displayed peptoids. Therefore, we …