Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"Oncogene addiction"”.
-
Identification and Characterization of Potential Novel Targets in Thyroid Carcinoma: Evidence of Non-Oncogene Addiction Unveiling Tumor Cell Vulnerabilities
… intervention, our laboratory faced the “non-oncogene addiction” (NOA) paradigm, which asserts that the tumorigenic state relies on the activity of genes that are essential to support the phenotype of cancer cells but not required to the same degree for normal cell viability. By screening a …
-
Taspase1 is a Non-oncogene Mediator of Tumorigenesis and Maintenance
The clinical success of oncogene-targeted therapies substantiates the continued reliance of certain cancers upon the continued function of apical oncogenes involved in its genesis--a phenomenon known as "oncogene addiction." Though this shift from non-targeted, cytotoxic therapies offers new hope …
-
Role of Nudix-Hydrolase ASMTL in Modulating Mitochondrial Biogenesis of Cancer Cells
… This study collectively exemplifies the non-oncogene addiction concept for cancer treatment and validates ASMTL as phenotypically lethal to carcinomas.
-
MYC-DEPENDENT TRANSCRIPTIONAL CONTROL IN HUMAN LYMPHOMA
… transcription and of the mechanisms underlying oncogene addiction in MYC-driven Lymphoma, paving the way for the identification of new therapeutic targets.
-
The Role of SOX2 in Colon Cancer Progression
… so that these cells are forced to change their oncogene addiction. In effect, high SOX2 expression causes clonal evolution of APC mutant CRC cells from a state of high Wnt dependency to a state of low Wnt dependency in the process making such cells resistant to Wnt inhibitor therapy. Enhanced …
-
Investigating the requirement of KRAS for the maintenance of pancreatic cancer
… studies have identified mutations in the proto-oncogene KRAS as a hallmark of PDAC, making KRAS an attractive therapeutic target. While the driver role of oncogenic KRAS for PDAC initiation has been well established, the degree of KRAS oncogene addiction in established PDAC tumors remains …
-
Oncogenic roles of RAS in acute myeloid leukemia cooperated with Mll-AF9.
… to study the oncogenic role of the NRAS oncogene ( NRAS G12V ) in the context of acute myeloid leukemia (AML). We transplanted AML, which was developed in Vav-tTA TRE-NRASG12V ; Mll-AF9 transgenic ( TRM -transgenic) mice, into recipient SCID mice. Conditional repression of NRAS G12V …