Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Omic analysis"”.
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Multi-omic Analysis of Neurodegeneration in Alzheimer’s Disease and Related Dementias
… ATAC sequencing (scATAC-seq) to perform a joint analysis of these conditions, examining both modalities holistically. Our research characterizes a multi-omic data set comprising 2,820,565 cells from 491 samples of prefrontal cortex across the aforementioned conditions, with all samples subjected …
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Multi-omic analysis of contaminated sediments from Contrecoeur, QC on Planorbid snails
… survival, growth, reproductive output, metabolomic profile, and proteomic profile. A two-week in-situ exposure was performed on Helisoma trivolvis, and a 28-d laboratory exposure of Planorbella pilsbryi to the same sediments was completed. Snail tissue samples were collected for proteomic and …
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Towards elucidating the function of the oocyte Subcortical Maternal Complex: A multi-omic analysis of an Nlrp5-null murine model
… molar pregnancies and imprinting disorders. Genomic imprinting depends upon correct patterning of DNA methylation over imprinted domains during oogenesis. It was previously shown that oocytes deficient in the human SCMC gene *KHDC3L* had globally impaired methylation, thus suggesting a role for …
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The Convergence of Accelerated and Physiological Vascular Ageing: A Multi-Omic Analysis of 2D and 3D in vitro models of Progeria
… heavily affected by HGPS. We performed transcriptomic analyses comparing HGPS-VSMCs to isogenic controls and wildtype VSMCs, before performing an unbiased comparison to transcriptomic data from primary aged SMCs, thus identifying core convergence of ageing signatures shared across both …
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The novel roles of BCL6 and BATF3 in regulating human CD8⁺ T cell dysfunction
… stimulated cells and integrative multi-omic analysis combining footprints, open chromatin regions, RNA-seq and ChIP-seq data revealed that putative BATF3 target genes may include master regulators of exhaustion. Moreover, overexpression of BCL6 or BATF3 markedly upregulates TIM-3 …
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The role of TREX1 and TREX2 in cellular responses to cisplatin
… cell death in cancer cells. Transcriptomic profiling of cisplatin-treated cancer cells identified the 3’ to 5’ exonucleases TREX1 and TREX2 as significantly upregulated DDR genes. Increased expression was confirmed at the protein level in two distinct cancer cell lines. Individual …
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Development of a framework for multiomic analysis in disease research
Multi-omics is the combination of several -omic terms to develop an interconnected understanding of molecular biology, which can provide increased insights into disease. Commonly known –omic terms include genomics, epigenomics, transcriptomics, proteomics and metabolomics. The potentials of …
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Investigating Tumour-Immune Cell Interactions in Paediatric Malignancies
… cell phenotype, including the diagnosis and genomic background, and prior exposure to therapy can shape the tumour immune microenvironment (TME) and that deep profiling of the patient TME could unmask clinically relevant biomarkers of response and inform future trials. This thesis aimed to both …
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Η μεταβολομική ως υψηλής απόδοσης βιομοριακή ανάλυση στη μηχανική κυτταροκαλλιεργειών
Η παρούσα εργασία αποτελεί μια συνεργασία μεταξύ του εργαστηρίου Μεταβολικής Μηχανικής και Συστημικής Βιολογίας στο ΙΤΕ / ΙΕΧΜΗ και της φαρμακοβιομηχανίας Bayer. Η φαρμακευτική βιομηχανία στρέφεται στην παραγωγή θεραπευτικών πρωτεϊνών με τη χρήση κυτταροκαλλιεργειών θηλαστικών, καθώς τα κύτταρα …