Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"Oligomycin"”.
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Effects of loigomycin, F0/F1 ATP-synthase inhibitor on mitochondrial morphology and dynamics
… (2-thenoyltrifluoro-acetone), antimycin A, and oligomycin] to investigate the complex-specific retrograde signal pathways. The inhibitors showed different effects on mitochondrial dynamics (distribution and morphology), but all accompanied apoptosis. Among the respiratory inhibitors, oligomycin …
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RNA editing and mutagenesis of the soybean (Glycine max) mitochondrial atp9 gene
… mitochondrial transformation. The antibiotic oligomycin is an inhibitor of the mitochondrial ATP synthase complex, and therefore has potential for the isolation of a marker gene. Two approaches, soybean tissue culture mutagenesis and site-directed mutagenesis of the soybean [Glycine max (L.) …
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Characterization, purification, and DNA sequence analysis of a novel ATPase of the archaebacterium Methanococcus voltae
… bafilomycin A$\sb1$, nitrate, ouabain and oligomycin. The enzyme displayed a high preference for ATP as substrate, was dependent on Mg$\sp{2+}$, and had a pH optimum of 7.5. The enzyme was completely solubilized with 2% Triton X-100. It was insensitive to oxygen and was stabilized by ATP.
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A systematic approach for cataloging mTORC1 regulators
… experiments with the mitochondrial inhibitor, oligomycin. Furthermore, we attributed these responses to the kinases, AMPK and HRI, respectively.
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The effects of furosemide on equine skeletal muscle satellite cell myogenesis and metabolism in vitro
… rate (OCR) and increased OCR after addition of oligomycin (P<0.05). Excess furosemide did not affect myotube glycolysis rates in vitro. In conclusion, furosemide inhibits muscle differentiation and oxidative metabolism in eqSCs.
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The genetics of glucosamine in yeast : cytoplasmic determinants conferring resistance
… and GR10 were not resistant to venturicidin or oligomycin and the GR factor exhibited genetic behaviour different from that of the episomal determinants. These results 7--+8 suggested that glucosamine resistance was not associated with the killer determinant nor with alleged yeast episomes. It …
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Use of estradiol-BSA conjugates to characterize membrane estrogen binding sites in brain cells: Biochemical and physiological studies
… with 17$\beta$-E-6-BSA and was identified as the oligomycin-sensitivity conferring protein (OSCP), a subunit of the F$\sb0$F$\sb1$ ATP-synthase/ATPase required for the coupling of a proton gradient across the F$\sb0$ sector of the mitochondrial membrane to ATP synthesis in the F$\sb1$ sector. …
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Mitochondrial Function as a Tool for Assessing Function, Quality and Adulteration in Medicinal Herbal Teas
… MCF7 cells pre-treated with 2000 μg / mL OLTE (oligomycin: 29.94%, p < 0.01; FCCP: 43.2%, p < 0.01; antimycin A & rotenone: 32.09%, p < 0.01). Further investigation revealed improved survival in 2000 μg / mL OLTE pre-treated MCF10A cells given cisplatin (50 μM: 11.79%, p < 0.05; 100 μM: 8.186%, …
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Translational tuning pre-emptively modulates protein folding and secretory pathway defects
… a drug pump to extrude the mitochondrial toxin, oligomycin. A genome wide screen was previously performed in our lab to identify factors that specifically contribute to biogenesis of a misfolded version of this protein, Yor1-F. The main focus of my thesis work is to investigate translation …
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Organismi acquatici e ambiente: meccanismi biochimici di interazione, risposta e adattamento
… the interaction of TBT with mussel mitochondrial oligomycin-sensitive Mg-ATPase. Since no literature data were available, the optimal assay conditions and oligomycin sensitivity of mussel mitochondrial MgATPase were determined. In T. philippinarum the ouabain-insensitive Na-ATPase was found to be …
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Involvement of mitochondrial dysfunction during transforming growth factor β1-induced senescence-like growth arrest of MvlLu cells
… of respiratory chain activities with KCN or oligomycin totally blocked the ROS generation. In addition, the mitochondrial respiration rate gradually diminished upon treatment with TGF β1 and the decrease was accompanied by reduced complex IV activity. These data suggested that the …
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LINEAGE TRACING REVEALS PAEP AS A CHEMOTHERAPY-INDUCED METASTATIC DRIVER AND EXPOSES METABOLIC VULNERABILITIES OF CIRCULATING TUMOR CELLS IN BREAST CANCER
… brief inhibition of ATP synthase with oligomycin increased ex vivo CTC viability, prolonged intravascular persistence, and enhanced lung seeding, functionally validating the survival advantage of respiratory restraint. Ongoing studies test the reciprocal prediction that oxidative …
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Synthesis of novel vanillin derivatives: study of their antioxidant and potential neuroprotective properties.
… hydrogen peroxide or a mixture of rotenone/oligomycin A as stressors, in a neuroblastoma SH-SY5Y cell line. Vanillin derivatives showed cellular protective effects, for example by increasing cell viability and reducing reactive oxygen species (ROS) production. However, they were unable to …
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Kinetische Auslöser der Ascosporenausschleuderung von Venturia inaequalis (Cke.) Wint.
… (Kresoxim-methyl, Azid), der ATP-Synthese (Oligomycin, Azid), der Translation in Mitochondrien (Chloramphenicol) und durch die osmotisch aktiven Verbindungen Saccharose, Glycerin, Mannit und Sorbit ab Konzentrationen von 0,15 M erreicht.
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Mitochondrial dynamics in demyelinated axons in a cerebellar slice culture system
… inhibitor mdivi-1 and the ATPase inhibitor oligomycin both showed an increasing or decreasing effect on the mitochondrial parameters after demyelination respectively. The effect on the axonal health after demyelination was detrimental with both of these treatments. Increasing mitochondrial …
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Biochemical Characterization of <i>Toxoplasma gondii</i> Type II NADH Dehydrogenases - Physiological Impact on Mitochondrial Functions and Energy Metabolism
… HDQ was stabilized with the F0-ATPase inhibitor oligomycin, indicating that T. gondii is likely to possess a conventional-like mitochondrial F0F1-ATPase. Additional subcellular localization of a membrane-associated F1-ATPase β subunit strongly supports this location, which is different to the …
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Investigations into mechanisms of magnesium homeostasis in the isolated rat heart
… with either rotenone, potassium cyanide (KCN) or oligomycin B promoted small but not significant increases in Mg 2 efflux and these were accompanied by significant decreases in force of contraction of the heart. Uncoupling phosphorylation and oxidation using dinitrophenol (DNP) elicited a highly …
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Mitochondrial dysfunction in hereditary optic neuropathies
… was achieved by culturing cells in presence of oligomycin, an inhibitor of ATP synthase complex. NARP cybrids have been used as model of mitochondrial pathology. Cell viability and ATP content have been considered as parameters to assay the capability of exogenous substrate to rescue energy …