Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 11 of 11 for “"Oligodendroglioma"”.
-
Using Genome-wide Approaches to Characterize the Relationship Between Genomic Variation and Disease: A Case Study in Oligodendroglioma and Staphylococcus arueus
… a nervous system brain tumor, known as oligodendroglioma (OD), using the CNV observed in tumors with varying degree of malignancy.</p><p>Using SNP data, we utilized a computational approach, known as in silico haplotype mapping (ISHM), to identify genomic regions significantly associated …
-
Inflammation-associated gene regulation in primary astrocytes, glial tumors and cellular differentiation
… first time that inflammation is associated with oligodendroglioma tumors as pro-inflammatory cytokines, such as OSM, IL-6, MCP1, MIP1α, and MIP1β and inflammatory markers, such as ACT and COX-2, were expressed at higher levels in oligodendroglioma samples. In addition, cytokine-induced STAT3 …
-
Exploring the immunologic consequences of ATRX deficiency in glioma
… human ATRX-deficient Astrocytoma and ATRX-intact Oligodendroglioma. In our murine models, we observed that ATRX-deficient tumors displayed immune dependent increases in survival and transcriptional upregulation of key immune gene sets. Alongside this, we observed an increased innate immune …
-
The effect of specific phospholipids that may have a possible role in propagating or inhibiting glioma
… into three areas namely: astrocytoma, oligodendroglioma and astro-oligodendroglioma (mixture of both). In our day-to-day diet, the public consume phospholipids from various sources of food products including egg, milk, soybean, offal and some vegetables. Environmental factors such as …
-
A clinicopathological and molecular genetic analysis of low-grade glioma in adults
… presented a more similar profile to oligodendroglioma, but anaplastic oligoastrocytoma was more similar to anaplastic astrocytoma. Five novel miRNAs were identified in grade III tumours, when comparing IDH1 mutant and IDH1 wild type tumours. Analysis of paired samples of …
-
Gain-of-Function Mouse Models to Investigate Biological Roles of Prmt6
… lymphoma, cervical cancer, bladder cancer, oligodendroglioma, breast cancer, and osteosarcoma, suggesting an oncogenic role for this enzyme. Importantly, we have found a positive correlation between PRMT6 over-expression and H3R2me2a elevation in small cell-lung cancer tissue arrays.</p> …
-
Effects of heat shock, hypoxia, post-mortem interval and glioma disease state on heat shock gene HSPA expression
… various types of glioma: (astrocytoma, oligodendroglioma and glioblastoma), with a normal human astrocyte cell line used as a control. In addition, 18 clinical brain tissue samples were also examined. HSPA RNA transcripts and proteins were examined in these samples using qRT-PCR, …
-
REGULATION OF YKL-40 IN STERILE INFLAMMATION AND ITS ROLE IN GLIOBLASTOMA IN VIVO
… model. YKL-40 expression is also up regulated in oligodendroglioma patient samples. We show that YKL-40 expression is activated by major pro-inflammatory cytokines including IL-1, IL-6, and OSM in astrocytes, and that the activation of YKL-40 expression by cytokines depends on the STAT and NF-κB …
-
Morphological and Immunocytochemical Investigation of Canine Oligodendrogliomas
… atypia were significantly greater in Grade III oligodendrogliomas than in Grade II oligodendrogliomas (p = 0.002, and p = 0.004, respectively), but no differences were noted between these features and Grade II oligoastrocytomas and Grade II or Grade III oligodendrogliomas. No significant …
-
Maximizing Local Access to Therapeutic Deliveries in Glioblastoma: Evaluating the utility and mechanisms of potential adverse events for minimally invasive diagnostic two novel therapeutic techniques for brain tumors
… all canine primary brain tumors, with high-grade oligodendroglioma and astrocytoma phenotypes accounting for about 70% of all canine gliomas. Canine gliomas are also treated using surgical, radiotherapeutic, and chemotherapeutic regimens similar to those used in humans. The efficacy of these …
-
Magnetic Resonance Spectroscopy Imaging of 2-Hydroxyglutarate in Brain Tumors at 3T and 7T In Vivo
The identification of 2-hydroxyglutarate (2HG) by 1H magnetic resonance spectroscopy (MRS) in patients with isocitrate dehydrogenase mutant gliomas is a significant breakthrough in neuro-oncology imaging. 2HG is the first imaging biomarker that is specific to a genetic mutation in gliomas, making …