Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Oligodendrogenesis"”.
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Regulation of Oligodendrogenesis in a Rat Contusive Spinal Cord Injury
… machinery could enhance the extent of oligodendrogenesis in the lesioned spinal cord. Specifically, ex vivo delivery of vascular endothelial growth factor (VEGF) was employed to increase oligodendrogenesis in rat spinal cord contusion model. I also delivered Olig genes to the …
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Establishment of the white matter stroke model in rats to study oligodendrogenesis
… ischemic demyelination by enhancing endogenous oligodendrogenesis would be a plausible therapeutic approach for ischemic stroke. We previously showed that overexpression of both Olig1 and Olig2 transcription factors enhances proliferation of oligodendrocyte progenitor cells and promotes …
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Lithium and brain plasticity - studies on glial cell changes and electroconvulsive treatment-induced amnesia in rats
… Decreased proliferation could reflect decreased oligodendrogenesis or possibly cell cycle arrest in favour of differentiation into oligodendrocytes. Thus, in paper II we investigated the effect of lithium on remyelination and oligodendrogenesis in corpus callosum after chemically induced …
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The Glial Response to Focused Ultrasound-mediated Permeabilization of the Blood-brain Barrier: Evaluating the Potential Contribution of Microglia and Astrocytes to Pathology and Regeneration
… neural progenitor cell (NPC) proliferation and oligodendrogenesis. NPC proliferation increased between 4D and 7D post-FUS and coincided with the activated astrocytic upregulation of insulin-like growth factor 2. Moreover, an increased proliferation of oligodendrocyte progenitors increased …
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The Role of Neuronal Activity in Adult Myelin Plasticity
… the grey and white matter; this *de novo* adult oligodendrogenesis plays a role in memory and learning. Research has also demonstrated that neuronal activity plays a central role in early myelin development and promotes oligodendrogenesis and adaptive myelination. Thus, it becomes important to …
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The effects of complex I deficiency on neurogenesis and white matter development in a mouse model of Leigh Syndrome (LS)
… programs and pathways linked to neurogenesis and oligodendrogenesis were significantly downregulated in KO neural progenitors. Although abundance of oligodendrocyte progenitors in the SVZ was not significantly altered, early and late myelin gene/protein expression was reduced, accompanied by …
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Neurogenesis and Gliogenesis from Ascl1 (Mash1) Expressing Progenitors in the Central Nervous System
… in constraining levels of Ascl1 is required in oligodendrogenesis. In chapter five, I revealed that Ascl1 is a common molecular marker of early progenitors of both neurons and oligodendrocytes in the adult brain, and these Ascl1 defined progenitors mature with distinct dynamics in different …
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Studies on the Roles of PDGFRA and EGFR in the Classification and Identification of Therapeutic Targets for Human Gliomas
… PM gliomas were enriched in the expression of oligodendrogenesis genes, whereas EMlowPMlow gliomas were enriched in the signatures of mature neurons and oligodendrocytes. These findings constitute a framework for improving molecular diagnosis and identifying therapeutic targets to combat …